Use of probiotics as an adjuvant to sequential H. pylori eradication therapy: impact on eradication rates, treatment resistance, treatment-related side effects, and patient compliance

Çekın, Ayhan Hilmi; Şahintürk, Yasin; Harmandar, Ferda; Uyar, Seyit; Yolcular, Başak Oğuz; Çekın, Yeşim

doi:10.5152/tjg.2016.0278

Cited by 42 publications

(40 citation statements)

References 44 publications

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“…Although, the eradication rate seemed to be higher in the synbiotic group, the difference was not statistically significant (ITT, p = 0.16, and PP, p = 0.19). To our knowledge, there are only two reports that used the same synbiotic treatment in H. pylori eradication [30, 32]. Similar to our results, Islek et al could not find a positive effect of this symbiotic treatment on eradication rates in H. pylori infected children [30].…”

Section: Discussionsupporting

confidence: 87%

“…On the other hand, the study by Çekin et al revealed significantly higher H. pylori eradication rates with sequential treatment and B. lactis B94 [32]. Furthermore, they have demonstrated lower diarrhea rates and higher treatment compliance in patients receiving B. lactis B94 [32]. Inconsistent with these studies, the patients in our study did not report any side effects that would require discontinuation of therapy.…”

Section: Discussionsupporting

confidence: 70%

“…However, there was a notable decrease on the occurrence of side effects in the synbiotic group which was interpreted as an indirect positive effect on eradication success [30]. On the other hand, the study by Çekin et al revealed significantly higher H. pylori eradication rates with sequential treatment and B. lactis B94 [32]. Furthermore, they have demonstrated lower diarrhea rates and higher treatment compliance in patients receiving B. lactis B94 [32].…”

Section: Discussionmentioning

confidence: 99%

“…Most studies in this area are mainly designed by using a single probiotic strain or a combination of strains. To our knowledge, there are currently a few studies assessing the effects of synbiotics on H. pylori eradication [30–32]. …”

Section: Introductionmentioning

confidence: 99%

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The Effects of Synbiotic “Bifidobacterium lactisB94 plus Inulin” Addition on Standard Triple Therapy ofHelicobacter pyloriEradication in Children

Üstündağ

ALTUNTAŞ

Soysal

et al. 2017

Canadian Journal of Gastroenterology and Hepatology

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Aim The aim of this study is to evaluate the effects of the synbiotic Bifidobacterium lactis B94 plus inulin addition to the standard triple therapy on Helicobacter pylori (H. pylori) infection eradication rates. Methods Children aged 6–16 years who had biopsy proven H. pylori infection were randomly classified into two groups. The first group received the standard triple therapy consisting of amoxicillin + clarithromycin + omeprazole. The second group was treated with the standard triple therapy and Bifidobacterium lactis B94 (5 × 109 CFU/dose) plus inulin (900 mg) for 14 days, concurrently. Eradication was determined by 14C-urea breath test 4–6 weeks after therapy discontinuation. Results From a total of 69 H. pylori infected children (F/M = 36/33; mean ± SD = 11.2 ± 3.0 years), eradication was achieved in 20/34 participants in the standard therapy group and 27/35 participants in the synbiotic group. The eradication rates were not significantly different between the standard therapy and the synbiotic groups [intent-to-treat, 58.8% and 77.1%, resp., p = 0.16; per-protocol, 64.5% and 81.8%, resp., p = 0.19]. There was no difference between the groups in terms of symptom relief (p = 0.193). The reported side effects were ignorable. Conclusion Considering the eradication rates, synbiotic addition to therapy showed no superiority over the standard triple therapy conducted alone. This trial is registered with NCT03165253.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effects of Synbiotic “Bifidobacterium lactisB94 plus Inulin” Addition on Standard Triple Therapy ofHelicobacter pyloriEradication in Children

Üstündağ

ALTUNTAŞ

Soysal

et al. 2017

Canadian Journal of Gastroenterology and Hepatology

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“…Reasons for loss to follow‐up for were ‘failure to make contact’, ‘time constraints’ and ‘personal issues’. Compliance is an important issue but often overlooked in probiotics trials or assessed only through self‐reports of taking prescribed supplements (Çekin et al, ). Adherence to taking probiotics, as prescribed, is key to their effectiveness and is important to consider (Sabat´e, ).…”

Section: Discussionmentioning

confidence: 99%

A double‐blind, paralleled‐arm, placebo‐controlled and randomized clinical trial of the effectiveness of probiotics as an adjunct in periodontal care

Pelekos

Acharya

et al. 2019

J Clinic Periodontology

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Aim This study aimed to evaluate the clinical effectiveness of the probiotic Lactobacillus reuteri as an adjunct to non‐surgical periodontal therapy (NSPT). Materials and Methods A double‐blind, paralleled‐arm, placebo‐controlled and randomized clinical trial was conducted. Probiotics L. reuteri or placebo lozenges were randomly prescribed for use twice‐daily for 28 days. Primary outcomes were clinical attachment levels (CAL) and probing pocket depths (PPD). All participants underwent NSPT, and follow‐up clinical assessments were performed at day 90 and day 180. Results The trial response rate was 69.5% (41 out of 59). Among the test and control groups, there were significant intra‐group differences in primary outcomes: CAL (both, p < .001) and PPD (both, p < .001); and in secondary outcomes: percentage of sites with ‘bleeding on probing’ (both, p < .001) and visible plaque (both, p < .001). There were no statistically significant inter‐group differences in any outcomes at any time points (all, p > .05) nor in the changes in outcomes (∆) with time (all, p > .05). There was a trend of a greater magnitude of statistical change occurring among the test group compared to the control group. Conclusion The adjunctive use of probiotics with NSPT did not show any additional clinical effectiveness when compared to NSPT alone in the management of periodontitis (ChiCTR‐IOR‐17010526).

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Role of probiotics in preventing adverse events related to Helicobacter pylori treatment

Buldukoglu,

Ocal,

Cekin

2024

UEG Journal

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Use of probiotics as an adjuvant to sequential H. pylori eradication therapy: impact on eradication rates, treatment resistance, treatment-related side effects, and patient compliance

Cited by 42 publications

References 44 publications

The Effects of Synbiotic “Bifidobacterium lactisB94 plus Inulin” Addition on Standard Triple Therapy ofHelicobacter pyloriEradication in Children

The Effects of Synbiotic “Bifidobacterium lactisB94 plus Inulin” Addition on Standard Triple Therapy ofHelicobacter pyloriEradication in Children

A double‐blind, paralleled‐arm, placebo‐controlled and randomized clinical trial of the effectiveness of probiotics as an adjunct in periodontal care

Role of probiotics in preventing adverse events related to Helicobacter pylori treatment

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