Levobupivacaine 0.75% vs. lidocaine 4% for topical anaesthesia

Donato, A. Di; Fontana, Carlos Eduardo; Lancia, F.; Giorgio, K. Di; Reali, S.; Caricati, Alessio

doi:10.1017/s0265021506002018

Cited by 9 publications

(9 citation statements)

References 10 publications

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“…Di Donato et al 22 in their recent study of 203 patients undergoing phacoemulsification surgery, clinically compared the efficiency of levobupivacaine 0.75% and lidocaine 4% as topical anaesthetic, and found that topical levobupivacaine 0.75% had the same efficacy and safety as lidocaine 4% in cataract surgery by phacoemulsification. There was an adequate block with a good level of satisfaction of surgeon and patients.…”

Section: Discussionmentioning

confidence: 99%

“…[18][19][20][21] Although levobupivacaine is routinely used to provide regional anaesthesia, the results of clinical studies on its topical administration for ophthalmic surgery appears in only one study. 22 In this study, we evaluated and compared the efficacy of topical application of lidocaine 2%, levobupivacaine 0.75%, and ropivacaine 1% in patients undergoing cataract surgery with phacoemulsification. The present study is the first report of a comparison of the effects of these three topical anaesthetic agents in cataract surgery.…”

Section: Introductionmentioning

confidence: 99%

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Comparative clinical trial of topical anaesthetic agents for cataract surgery with phacoemulsification: lidocaine 2% drops, levobupivacaine 0.75% drops, and ropivacaine 1% drops

Borazan

Karalezlı

Akova

et al. 2007

Eye

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Purpose To assess the safety and efficacy of topical lidocaine, levobupivacaine, and ropivacaine in cataract surgery with phacoemulsification. Methods One hundred and five patients scheduled for cataract surgery with topical anaesthesia were randomly allocated into 3 groups of 35 patients each to receive eye drops of lidocaine 2%, levobupivacaine 0.75%, or ropivacaine 1% every 5 min starting 30 min before surgery. Patients graded their pain using a 0-10-point verbal pain score (VPS) at different stages of the procedure. The levels of patient and surgeon satisfaction, the duration of surgery, complications, and the need for supplemental anaesthesia were recorded. Results There was no significant difference in duration of surgery and demographic variables among the groups. At the intraoperative period, end of surgery, and postoperative first hour the mean VPS in the lidocaine group was significantly higher than the others (Po0.01), but no significant difference was found between the levobupivacaine and ropivacaine groups. At incision and 24 h after surgery, it was not significantly different among the groups. Surgeon and patient satisfaction scores were significantly better in the levobupivacaine and ropivacaine groups than in the lidocaine group (Po0.01).Conclusions Topical anaesthesia with levobupivacaine and ropivacaine were safe, feasible and more effective than lidocaine in cataract surgery. Levobupivacaine and ropivacaine provided sufficient and long-lasting analgesia without the need of supplemental anaesthesia for each patient.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparative clinical trial of topical anaesthetic agents for cataract surgery with phacoemulsification: lidocaine 2% drops, levobupivacaine 0.75% drops, and ropivacaine 1% drops

Borazan

Karalezlı

Akova

et al. 2007

Eye

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“…[1][2][3][4][5][6] Lidocaine, ropivacaine, and levobupivacaine are 3 commonly used topical anesthetic agents in modern cataract surgery. [7][8][9] Topical anesthesia does not provide adequate motor and sensory anesthesia and may be associated with increased intraoperative pain and complications. 4 Therefore, intracameral injection of unpreserved lidocaine 1% has become a commonly used adjunctive anesthetic agent during cataract surgery.…”

mentioning

confidence: 99%

“…[16][17][18][19][20][21][22][23][24][25][26][27] There is only a single report in the literature that presents the effects of intracameral ropivacaine in rabbit eyes. 28 Although there has been ongoing research on the use of levobupivacaine for topical anesthesia, 7,8 intracameral application of this agent has not been studied. Therefore, the purpose of this study was to quantify and compare the effects of intracameral injection of 3 anesthetic agentsdpreservativefree lidocaine hydrochloride 2%, ropivacaine 1%, and levobupivacaine 0.75%don the rabbit corneal endothelium.…”

mentioning

confidence: 99%

Induction of apoptosis of rabbit corneal endothelial cells by preservative-free lidocaine hydrochloride 2%, ropivacaine 1%, or levobupivacaine 0.75%

Borazan¹,

Karalezlı²,

Oto³

et al. 2009

Journal of Cataract and Refractive Surgery

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Intracameral injections of preservative-free lidocaine, ropivacaine, and levobupivacaine induced significantly more apoptotic endothelial cell loss than BSS Plus and led to morphologic changes in the corneal endothelial cells in the early period. This effect was temporary, with recovery by 7 days. Considering the limited proliferative capacity in human eyes, the induced apoptosis might result in the permanent cell loss and enlargement in human corneal endothelium.

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“…12 Pa ti ent sa tis fac ti on was re ported as 83% in li do ca i ne-bu pi va ca i ne tre a ted gro up and 97% in ro pi va ca i ne tre a ted gro up in a study which com pa red pe ri bul bar anest he si a with eit her 0.75% ro pi va ca i ne or 2% li do ca i ne-0.5% bu pi va cai ne mix tu re for vit re o re ti nal sur gery. 13 In anot her study, re se arc hers re por ted a trend to wards bet ter sa tis fac ti on in pa ti ents ad mi nis te red le vo bu pi va cai ne com pa red to ro pi va ca i ne at 24 ho urs fol lo wing ope ra ti on.…”

Section: Discussionunclassified

Comparison of 0.5% Levobupivacaine and 0.5% Bupivacaine for Retrobulbar Anesthesia in Cataract Surgery

Aksu¹,

Biçer²,

Özkırış³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : The aim of the study is to com pa re the ef fi cacy of lo cal an est he tics, le vobu pi va ca i ne and bu pi va ca i ne, for ac hi e ve ment of ret ro bul bar anest he si a and to determine pa ti ent and sur ge on sa tis fac ti on in ca ta ract sur gery. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : One hundred and twenty pa tients sche du led for ca ta ract sur gery we re ran do mi sed, in a do ub le-blind fas hi on to re ce i ve 5 ml of 0.5% le vo bu pi va ca i ne or 5 ml of 0.5% bu pi va ca i ne vi a in fe ro tem po ral in jec ti on for ac hi e ve ment of ret ro bul bar ana est he si a. Mo tor block du ra ti ons and pa in on set ti mes we re re cor ded. Se ve rity of intra and pos to pe ra ti ve pa in was as ses sed by using vi su al ana lo gu e pa in sca le. The ef fi ci ency of an est he si a, pa ti ent and sur ge on sa tis fac ti on, and aki ne si a du ra ti ons we re as ses sed by using po int sco ring sca les. He mody na mic da ta and ad ver se events we re re cor ded. R Re e s su ul lt ts s: : Pa in on in jec ti on (le vo bu piva ca i ne 18%, bu pi va ca i ne 36.7%) was fo und to be mo re fre qu ent in gro up B. The aki ne si a sco re after 10 mi nu tes (me di an; 0, 1 res pec ti vely) and sen so ri al block on set ti me (2, 3 min) in le vo bu pi va ca i ne gro up was lo wer than bu pi va ca i ne gro up but, aki ne si a sco res in both gro ups we re un der 4 and ade qu a te for sur gery. Sur ge on and pa ti ent sa tis fac ti on re gar ding anest he si a we re al so hig her in le vo bu pi va ca i ne gro up (me di an 10 and 10) com pa red to bu pi va ca i ne gro up (me di an 9 and 9) alt ho ugh the me di ans of two gro ups were clo se. C Co on nc c l lu u s si i o on ns s: : Le vo bu pi va ca i ne pro vi des bet ter sur ge on and pa ti ent sa tis fac ti on compared to bu pi va ca i ne for ret ro bul bar an est he si a in ca ta ract surgery, and this fin ding sho uld be sup por ted by new and com pre hen si ve cli ni cal stu di es. K Ke ey y W Wo or rd ds s: : Leobupivacaine; bupivacaine; cataract Ö ÖZ ZE ET T A Am ma aç ç: : Bu ça lış ma nın ama cı ka ta rakt cer ra hi sin de ret ro bul ber anes te zi sağ lan ma sın da lo kal anes te tik ler le vo bu pi va ka in ile bu pi va ka i nin et kin li ği nin ve has ta ve cer rah mem nu ni ye ti nin kar-şı laş tı rıl ma sı dır. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Ka ta rakt cer ra hi si ya pıl ma sı plan la nan 120 has ta in fra tem poral en jek si yon la ret ro bul ber anes te zi sağ la mak için 5 ml %5 le vo bu pi va ka in ve ya 5 ml %0.5 bu pi va ka in ve ri le cek şekil de çift kör ola rak rast ge le da ğı tıl dı. Mo tor blok sü re le ri ve ağ rı nın or taya çı kış za man la rı kay de dil di. Ame li yat sı ra sın da ki ve ame li yat tan son ra ki ağ rı nın şid de ti gör sel ana log ağ rı ska la sı kul la nı la rak de ğer len di ril di. Anes te zi nin et kin li ği, has ta ve cer rah mem nu ni yeti ve aki ne zi sü re le ri nok ta skor la ma ska la la rı kul la nı ...

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Levobupivacaine 0.75% vs. lidocaine 4% for topical anaesthesia

Cited by 9 publications

References 10 publications

Comparative clinical trial of topical anaesthetic agents for cataract surgery with phacoemulsification: lidocaine 2% drops, levobupivacaine 0.75% drops, and ropivacaine 1% drops

Comparative clinical trial of topical anaesthetic agents for cataract surgery with phacoemulsification: lidocaine 2% drops, levobupivacaine 0.75% drops, and ropivacaine 1% drops

Induction of apoptosis of rabbit corneal endothelial cells by preservative-free lidocaine hydrochloride 2%, ropivacaine 1%, or levobupivacaine 0.75%

Comparison of 0.5% Levobupivacaine and 0.5% Bupivacaine for Retrobulbar Anesthesia in Cataract Surgery

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