Levetiracetam induced mania – A case report

A Manic Episode With Psychotic Features Associated With Levetiracetam

“…In our case, before the full manic syndrome with psychotic features was established, our patient presented with affective-mixed symptoms such as dysphoria, irritability, mood lability, and aggressiveness. Most levetiracetam-associated manic/psychotic episodes reported in the literature were preceded by irritability, 2–5 mood lability, 2,4 aggressiveness, and psychomotor agitation 2 . This affective-mixed symptoms complex may be a prodromal marker of subsequent severe manic/psychotic episodes 12,13 .…”

“…1 Levetiracetamassociated manic episodes have rarely been described. [2][3][4][5] However, several cases of psychotic episodes associated with levetiracetam have been reported. 6 We would like to discuss a case of a manic episode with psychotic symptoms associated with levetiracetam in a patient with no previous history of affective disorders.…”

“…Depression, irritability, and anxiety are the most common 1 . Levetiracetam-associated manic episodes have rarely been described 2–5 . However, several cases of psychotic episodes associated with levetiracetam have been reported 6 .…”