Levetiracetam in a Neonate With Malignant Migrating Partial Seizures

Hmaimess, Ghassan; Kadhim, Hazim; Nassogne, Marie‐Cécile; Bonnier, Christine; Rijckevorsel, Kenou van

doi:10.1016/j.pediatrneurol.2005.06.011

Cited by 52 publications

(51 citation statements)

References 6 publications

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“…17 New epileptic drugs such as zonisamide and topiramate were found to be ineffective, and, in one case, levetiracetam decreased seizure frequency and improved both the clinical picture and EEG recording. 18 Although widely used in patients with nonketotic hyperglycinemia, the experience of DM usage in children with epilepsy is limited. 2e7 DM is effective in elevating the threshold for the cough reflex, suppressing convulsions or their experimental correlate, and reducing the neuronal damage induced by ischemia or excitatory amino acids.…”

Section: Discussionmentioning

confidence: 99%

Dextromethorphan in the treatment of early myoclonic encephalopathy evolving into migrating partial seizures in infancy

Chien

Lin²,

Weng

et al. 2012

Journal of the Formosan Medical Association

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Epileptic encephalopathy with suppression-burst in electroencephalography (EEG) can evolve into a few types of epileptic syndromes. We present here an unusual case of early myoclonic encephalopathy that evolved into migrating partial seizures in infancy. A female neonate initially had erratic myoclonus movements, hiccups, and a suppression-burst pattern in EEG that was compatible with early myoclonic encephalopathy. The seizures were controlled with dextromethorphan (20 mg/kg), and a suppression-burst pattern in EEG was reverted to relatively normal background activity. However, at 72 days of age, alternating focal tonic seizures, compatible with migrating partial seizures in infancy, were demonstrated by the 24-hour EEG recording. The seizures responded poorly to dextromethorphan. To our knowledge, this is the first reported case of early myoclonic encephalopathy evolving into migrating partial seizure in infancy. Whether it represents another age-dependent epilepsy evolution needs more clinical observation.

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Section: Discussionmentioning

confidence: 99%

Dextromethorphan in the treatment of early myoclonic encephalopathy evolving into migrating partial seizures in infancy

Chien

Lin²,

Weng

et al. 2012

Journal of the Formosan Medical Association

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“…Since then, numerous other groups have also identified patients who fit these original criteria, selected references of which are reviewed and summarized in Table 2 (Coppola et al, 1995, 2006, 2007; Okuda et al, 2000; Veneselli et al, 2001; Gross-Tsur et al, 2004; Marsh et al, 2005; Hmaimess et al, 2006; Caraballo et al, 2008; Carranza Rojo et al, 2011; Sharma et al, 2011; Barcia et al, 2012; Lee et al, 2012; Ishii et al, 2013; McTague et al, 2013; Milh et al, 2013). Ongoing analyses of these patients using EEGs, brain imaging and DNA sequence analysis continue to shape the field’s understanding of this focal seizure in infancy.…”

Section: Slack Channels In Cognitive Disordersmentioning

confidence: 99%

Emerging role of the KCNT1 Slack channel in intellectual disability

Kim

Kaczmarek

2014

Front. Cell. Neurosci.

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The sodium-activated potassium KNa channels Slack and Slick are encoded by KCNT1 and KCNT2, respectively. These channels are found in neurons throughout the brain, and are responsible for a delayed outward current termed IKNa. These currents integrate into shaping neuronal excitability, as well as adaptation in response to maintained stimulation. Abnormal Slack channel activity may play a role in Fragile X syndrome, the most common cause for intellectual disability and inherited autism. Slack channels interact directly with the fragile X mental retardation protein (FMRP) and IKNa is reduced in animal models of Fragile X syndrome that lack FMRP. Human Slack mutations that alter channel activity can also lead to intellectual disability, as has been found for several childhood epileptic disorders. Ongoing research is elucidating the relationship between mutant Slack channel activity, development of early onset epilepsies and intellectual impairment. This review describes the emerging role of Slack channels in intellectual disability, coupled with an overview of the physiological role of neuronal IKNa currents.

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“…There are 2 published reports describing therapeutic use of levetiracetam in 4 infants, each of whom had adequate seizure control and no adverse effects. 94,95 Topiramate is a broad-spectrum antiepileptic drug with several mechanisms of action including use-dependent blockade of voltage-activated sodium channels, enhancement of GABA-mediated chloride flux, attenuation of glutamate-mediated calcium influx via antagonism at the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)Àkainate receptor, attenuation of high-voltage-activated calcium channels as well as weak inhibition of carbonic anhydrase. Topiramate is an exciting option for use as an antiepileptic drug because it also has known neuroprotective effects in animal models of hypoxic-ischemic brain injury.…”

Section: Newer Antiepileptic Agentsmentioning

confidence: 99%

Controversies in Neonatal Seizure Management

Glass

Wirrell

2009

J Child Neurol

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Seizures in the newborn period are common and frequently indicate serious underlying brain injury. Although accumulating evidence suggests that they may impair brain development, there are currently no evidence-based guidelines for evaluation and management of neonatal seizures. In this review, we will address some of the current controversies facing child neurologists and neonatologists, including how to define, monitor, and treat neonatal seizures.

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Levetiracetam in a Neonate With Malignant Migrating Partial Seizures

Cited by 52 publications

References 6 publications

Dextromethorphan in the treatment of early myoclonic encephalopathy evolving into migrating partial seizures in infancy

Dextromethorphan in the treatment of early myoclonic encephalopathy evolving into migrating partial seizures in infancy

Emerging role of the KCNT1 Slack channel in intellectual disability

Controversies in Neonatal Seizure Management

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