Levels of serum creatinine and estimated creatinine clearance over the age of 75: a study of an elderly Swedish population

Fastbom, Johan; Wills, Phillippa; Cornelius, Christel; Viitanen, Matti; Winblad, Bengt

doi:10.1016/0167-4943(96)00719-4

Cited by 17 publications

(19 citation statements)

References 20 publications

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“…The present study confirms an age-related decline in renal function, in terms of decreased GFR (13,15Á/17) and that elderly women in general have lower GFR than men (11,15,18). Altogether 85% of the study population, and 99% of patients aged 85 and over, had moderate or severe reduction in GFR (GFR B/60 ml/ min).…”

Section: Discussionsupporting

confidence: 88%

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Sputum specimens can be obtained from patients with community-acquired pneumonia in primary care

Lagerström

Fredlund

Holmberg

2004

Scandinavian Journal of Primary Health Care

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Section: Discussionsupporting

confidence: 88%

“…Death at younger age among diabetics and persons with hypertension may also be a contributing factor. In line with other studies, we observed only a slight age-related increase in S-Cr (15,18,21). We were not able assess other complications of impaired renal function, e.g.…”

Section: Discussionsupporting

confidence: 87%

Sputum specimens can be obtained from patients with community-acquired pneumonia in primary care

Lagerström

Fredlund

Holmberg

2004

Scandinavian Journal of Primary Health Care

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“…These observations are confirmed by O'Hare et al [24 ]who show that in elderly men the risk of death exceeds the risk of ESRD until eGFR falls <15 ml/min/1.73 m 2 . The -16.6 ml/min/1.73 m 2 per decade loss of renal function was more than one and a half times greater than reported [8,9], although these studies were cross sectional with wide age-spans. The women in our cohort are identically aged, increasing the probability of accurately calculating function loss over time.…”

Section: Discussionmentioning

confidence: 48%

“…Cross-sectional studies report that estimated glomerular filtration rate (eGFR) diminishes by approximately 10 ml/min/1.73 m 2 per decade from middle age [8,9]. …”

Section: Introductionmentioning

confidence: 99%

Declining Estimated Glomerular Filtration Rate and Its Association with Mortality and Comorbidity Over 10 Years in Elderly Women

Malmgren

McGuigan

Berglundh

et al. 2015

Nephron

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Background/Aims: Renal function deteriorates with age, but a few studies have addressed this longitudinally in elderly women. Our objective was, using 5 estimated glomerular filtration rates (eGFR)-equations, to evaluate changes in renal function and association with adverse outcomes for a decade in 75-year-old women. Methods: Plasma creatinine was measured at ages 75 (n = 1,011), 78 (n = 827), 80 (n = 689) and 85 (n = 363). Glomerular filtration rates were estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI); Modification of Diet in Renal Disease (MDRD); revised Lund-Malmö (LM-rev); Berlin Initiative Study 1 (BIS1) and Cockcroft-Gault/body surface area (CG/BSA) equations. Mortality and comorbidity were investigated in women with chronic kidney disease (CKD) stage 3A and 3B-5. Results: Approximately, 95% of women had eGFR indicating CKD stage 2-3 and progression towards stage 3 was continuous. The women lost 22% of their eGFR during follow-up and loss accelerated between 80 and 85. Mean loss per decade was 16.6 ml/min/1.73 m². Women in CKD stage 3B-5 had an adjusted hazard ratio for death of 3.5 (95% CI 2.1-5.8) compared to stage 1-2 during follow-up and increased risk of diabetes, heart failure and hypertension. The CG/BSA, BIS1 and LM-rev equations continuously predicted lower eGFR than the MDRD and CKD-EPI equations. Conclusion: eGFR in women aged 75-85 ranges from 30 to 89 ml/min/1.73 m² (stage 2-3). Decline was 16.6 ml/min/1.73 m² per decade; accelerated with age and appeared nonlinear. Women with CKD 3B-5 demonstrate an over 3-fold risk of death. eGFR <45 ml/min/1.73 m² was associated with mortality, confirming the new KDIGO classification 3A and 3B, as clinically applicable in the elderly.

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“…We also assessed blood urea and serum creatinine carefully, which allowed tracking of renal function. The level of creatinine in the blood depends on the amount of muscle mass and is not affected by diet, and creatinine levels do not change significantly with increasing age [29]. Lower values are common in people with reduced muscle mass, and are associated with prolonged periods of being bed-ridden.…”

Section: Discussionmentioning

confidence: 99%

Nutritional Status Assessment of Institutionalized Elderly in Prague, Czech Republic

et al. 2013

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Background: There are few studies in the Czech Republic describing and evaluating the nutritional status of institutionalized elderly. Methods: Data were collected from 659 women and 156 men aged 65 years and older and living in retirement homes in and around Prague. Data included: a Mini-Nutritional Assessment (MNA questionnaire), anthropometric measurements and biochemical evaluations. Results: According to the MNA questionnaire, 10.2% of these elderly individuals were malnourished and 39.4% were at risk of malnutrition. More women than men were malnourished (OR = 0.59 and 95% CI 0.42-0.86). Mean BMI values were 25.5 for females and 27.5 for males. MNA was positively correlated mostly with immobility (r = 0.63; p < 0.001), BMI (r = 0.57; p < 0.001) and mid-arm circumference (r = 0.56; p < 0.001). Serum albumin levels were <28 g/l in 1.3% (1.3% of the women and 1.36% of the men) and between 29.0 - 34.0 g/l in 21% (22.5% of the women and 14.4% of the men). Statistically significant differences between groups according to MNA scores were found for albumin, prealbumin, transferrin and creatinine. Prevalence of smoking was significantly higher among males. Conclusion: The study results confirmed that institutionalized elderly, especially women, should be considered a nutritionally vulnerable population group that needs attention.

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Levels of serum creatinine and estimated creatinine clearance over the age of 75: a study of an elderly Swedish population

Cited by 17 publications

References 20 publications

Sputum specimens can be obtained from patients with community-acquired pneumonia in primary care

Sputum specimens can be obtained from patients with community-acquired pneumonia in primary care

Declining Estimated Glomerular Filtration Rate and Its Association with Mortality and Comorbidity Over 10 Years in Elderly Women

Nutritional Status Assessment of Institutionalized Elderly in Prague, Czech Republic

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