Levels of Proinflammatory Cytokines Il-17 and Il-23 in Patients With Alzheimer’s Disease, Mild Cognitive Impairment and Vascular Dementia

Dubenko, O.Ye.; Chyniak, O. S.; Potapov, O. O.

doi:10.36740/wlek202101113

Cited by 12 publications

(12 citation statements)

References 20 publications

(18 reference statements)

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“…In experimental models of multiple sclerosis, high levels of IL-17 over observed proximal to CA1 hippocampal neurons [ 34 ]. Prior reports have also suggested that VD patients exhibit significant increases in IL-17 levels as compared to healthy individuals, consistent with a more robust inflammatory response, with similar reports for Alzheimer's disease [ 35 ]. Consistently, we observed increased IL-17 levels in the spleen and peripheral blood of VD model rats.…”

Section: Discussionsupporting

confidence: 83%

Acupuncture regulates the Th17/Treg balance and improves cognitive deficits in a rat model of vascular dementia

Liu¹,

Pan²,

Zhenzhen³

et al. 2023

Heliyon

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Section: Discussionsupporting

confidence: 83%

Acupuncture regulates the Th17/Treg balance and improves cognitive deficits in a rat model of vascular dementia

Liu¹,

Pan²,

Zhenzhen³

et al. 2023

Heliyon

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“…Although accumulating evidence suggests that IL-17A has the potential to serve as a biomarker for AD, the IL-17A level detected in AD patients is inconsistent among different population-based cohort studies. Some results support that IL-17A level is significantly higher in AD than those of control [ 2 , 94 , 95 ], but the other reported a reduced IL-17A level in AD patients [ 5 ]. The conflicting results may be due to a lack of clinical dementia rating as the immune events may change during the disease course.…”

Section: Discussionmentioning

confidence: 94%

Interleukin-17A in Alzheimer’s Disease: Recent Advances and Controversies

Yan

Lai

et al. 2022

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: Alzheimer’s disease (AD) is a progressive neurodegenerative disease which mainly affects older adults. Although the global burden of AD is increasing year by year, the causes of AD remain largely unknown. Numerous basic and clinical studies have shown that interleukin-17A (IL-17A) may play a significant role in the pathogenesis of AD. A comprehensive assessment ofthe role of IL-17A in AD would benefit the diagnosis, understanding of etiology and treatment. However, over the past decade controversies remain regarding the expression level and role of IL-17A in AD. We have incorporated newly published researches and point out that IL-17A expression levels may vary along with the development of AD, exercising different roles at different stages of AD, although much more work remains to be done to support the potential role of IL-17A in AD-related pathology.Here, it is our intention to review the underlying mechanisms of IL-17A in AD and address the current controversies, in an effort to clarify the results of existing research and suggest future studies.

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“…In addition, Dubenko et al showed that IL-17 and IL-23 levels were significantly higher in AD patients than in controls [33]. Therefore, in this study, we investigated changes in proinflammatory cytokines in the peripheral circulation of 5XFAD mice.…”

Section: Electroacupuncture (Ea) Reduces Proinflammatory Cytokines In the Peripheral Circulation Of 5xfad Micementioning

confidence: 89%

Electroacupuncture ameliorates blood-brain barrier dysfunction in 5XFAD Alzheimer’s animal model

Cai¹,

Lee²,

Yang³

2021

J Biomed Transl Res

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Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disease accompanied by aging, followed by memory impairment and cognitive decline. Although numerous attempts have been made to develop treatments for AD, most clinical trials have failed to delay or stop the progression of AD. Electroacupuncture (EA) is a complementary alternative medicine technique widely used to treat pain, inflammation, and neurodegenerative diseases. Additionally, blood-brain barrier (BBB) disruption is a known pathophysiology of neurodegenerative diseases, including AD. Moreover, amyloid beta deposition increases BBB permeability and produces inflammatory cytokines induced by glial activation. However, our previous study revealed that EA treatment at the Taegye acupoints (KI3) improves memory impairment through anti-neuroinflammation and increases glucose metabolism in 5XFAD mice. Therefore, we evaluated whether EA treatment at KI3 regulates BBB dysfunction in the prefrontal cortex of 5XFAD mice. For this study, 6.5-month-old 5XFAD mice were treated with EA stimulation at KI3 three times a week for two weeks. Western blotting, immunohistochemistry, and flow cytometry were used to evaluate the effects of EA treatment on BBB dysfunction. We found that EA stimulation attenuates BBB integrity by protecting BBB tight junction proteins (CD31, aquaporin 4, occludin, and claudin 5) in the prefrontal cortex of 5XFAD mice. In addition, EA treatment regulated inflammatory cytokines (IL-1α, IL-1β, IL-17, IL-23, IFN-ɣ, monocyte chemoattractant protein 1 (MCP-1), granulocyte-macrophage colony stimulating factors [GM-CSF], and IL-10) in the peripheral circulation of 5XFAD mice. Therefore, our data suggest that EA treatment could be a therapeutic agent for enhancing BBB dysfunction in AD.

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Levels of Proinflammatory Cytokines Il-17 and Il-23 in Patients With Alzheimer’s Disease, Mild Cognitive Impairment and Vascular Dementia

Cited by 12 publications

References 20 publications

Acupuncture regulates the Th17/Treg balance and improves cognitive deficits in a rat model of vascular dementia

Acupuncture regulates the Th17/Treg balance and improves cognitive deficits in a rat model of vascular dementia

Interleukin-17A in Alzheimer’s Disease: Recent Advances and Controversies

Electroacupuncture ameliorates blood-brain barrier dysfunction in 5XFAD Alzheimer’s animal model

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