Acupuncture regulates the Th17/Treg balance and improves cognitive deficits in a rat model of vascular dementia

Liu, Qiuping; Pan, Pan; Zhenzhen, Ling; Li, Shu-Ting; Zhang, Xuezhu; Zhang, Zhen

doi:10.1016/j.heliyon.2023.e13346

Cited by 6 publications

(3 citation statements)

References 74 publications

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“…After cerebral ischemia, it is often observed that Treg cell activity decreases and/or Th17 cell activity increases ( Kleinschnitz et al, 2013 ). MA at the above acupoints can also reduce the frequency and quantity of Th17 cells in these animals, increase Treg cell levels, regulate Th17/Treg balance, reduce CD4 + RORγT + and RORγT + cells, increase CD4 + FoxP3 + and FoxP3 + cell counts, thereby alleviating cognitive deficits in spatial learning and memory disorders ( Qiuping et al, 2023 ). Toll like receptors (TLRs) are important pattern recognition receptors in the innate immune system, which initiate inflammatory cascade reactions by recognizing pathogen associated molecule pattern (PAMPs) and damage associated molecular patterns (DAMPs) ( Aravalli et al, 2007 ).…”

Section: Resultsmentioning

confidence: 99%

The effects and mechanisms of acupuncture for post-stroke cognitive impairment: progress and prospects

Wang

Liu³

et al. 2023

Front. Neurosci.

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Stroke is one of the important causes of both disability and death worldwide, which is very common in older adults. Post-stroke cognitive impairment (PSCI) is a common secondary damage of stroke, which is the main cause of long-term disability and decreased quality of life in stroke patients, which brings a heavy burden to society and families. Acupuncture, as one of the oldest and widely used worldwide techniques in Chinese medicine, is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for improving stroke care. This review comprehensively summarizes literature from the last 25 years, showing that acupuncture can exert strong beneficial effect on PSCI. The mechanisms of acupuncture on PSCI involves anti-neuronal apoptosis, promoting synaptic plasticity, alleviating central and peripheral inflammatory reactions, and regulating brain energy metabolism disorders (including improving cerebral blood flow, glucose utilization and mitochondrial structure and function, etc.), etc. The effects and mechanisms of acupuncture on PSCI reviewed in this study provides scientific and reliable evidence for acupuncture application for PSCI.

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Section: Resultsmentioning

confidence: 99%

The effects and mechanisms of acupuncture for post-stroke cognitive impairment: progress and prospects

Wang

Liu³

et al. 2023

Front. Neurosci.

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“… 68 , 69 Additionally, emerging evidence highlights the key role of Th17 cells in RA pathogenesis. 70 Their elevated presence in RA patients and their ability to secrete pro-inflammatory cytokines like IL-17A further illustrate their pathogenic contribution. 71–73 Furthermore, clinical studies report high levels of IL-17A in RA patients, and anti-IL-17 therapy has demonstrated efficacy in reducing arthritis severity in animal models.…”

Section: Discussionmentioning

confidence: 99%

Luobitong Potentiates MTX’s Anti-Rheumatoid Arthritis Activity via Targeting Multiple Inflammatory Pathways

Li,

Zhang,

Gao

et al. 2024

JIR

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“…For instance, one study showed that an imbalance in Th17/Treg cells exacerbates cognitive impairment by activating the STAT3 pathway ( 30 ). Another study found that Th17/Treg cells facilitate cognitive deficits in a vascular dementia rat model ( 31 ). This study showed that an elevated Th17/Treg ratio was associated with a reduced MMSE score at enrollment in stroke patients, which reflected the crucial role of the Th17/Treg imbalance in the progression of cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

Serum retinol-binding protein 4 in stroke patients: correlation with T helper 17/regulatory T cell imbalance and 3-year cognitive function decline

Wang,

Qin,

2023

Front. Neurol.

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ObjectiveRetinol-binding protein 4 (RBP4) promotes atherosclerotic progression and neuronal loss, whereas its association with cognitive impairment in stroke is unclear. Hence, this prospective study aimed to explore the association of serum RBP4 with the T helper (Th)17/regulatory T (Treg) cell ratio and its correlation with cognitive impairment in stroke patients.MethodsPeripheral blood samples from 265 stroke patients and 50 healthy controls (HCs) were collected at enrollment for serum RBP4 (by enzyme-linked immunosorbent assay) and Th17 and Treg cells (by flow cytometry) determination. Additionally, stroke patients underwent routine follow-ups, and their Mini-Mental State Examination (MMSE) scores were assessed at baseline and in years 1, 2, and 3 after enrollment.ResultsSerum RBP4 was elevated in stroke patients compared to HCs (p < 0.001), with a good ability to differentiate stroke patients from HCs (area under the curve: 0.815). Serum RBP4 was positively associated with Th17 cells (p < 0.001) and the Th17/Treg cell ratio (p < 0.001) and negatively associated with Treg cells (p = 0.003) in stroke patients, whereas it was only positively associated with the Th17/Treg cell ratio (p = 0.027) but not with Th17 (p = 0.075) or Treg (p = 0.130) cells in HCs. Furthermore, increased serum RBP4 was associated with a lower MMSE score (p < 0.001) and a lower incidence of cognition impairment (p = 0.005) at enrollment in stroke patients, as were Th17 cells and the Th17/Treg cell ratio (all p < 0.050). The 1-, 2-, and 3-year MMSE scores in stroke patients were 25.9 ± 2.0, 25.3 ± 2.3, and 24.9 ± 2.3, respectively. More importantly, serum RBP4 was negatively correlated with 1-, 2-, and 3-year MMSE scores (all p < 0.001) and positively associated with 1-year (p = 0.013), 2-year (p = 0.007), and 3-year (p = 0.001) MMSE score declines in stroke patients.ConclusionSerum RBP4 is positively associated with a Th17/Treg cell imbalance and, more importantly, it is indicative of cognitive function decline within 3 years in stroke patients. Thus, early and timely interventions and physical rehabilitation are more necessary in stroke patients with high serum RBP4.

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Acupuncture regulates the Th17/Treg balance and improves cognitive deficits in a rat model of vascular dementia

Cited by 6 publications

References 74 publications

The effects and mechanisms of acupuncture for post-stroke cognitive impairment: progress and prospects

The effects and mechanisms of acupuncture for post-stroke cognitive impairment: progress and prospects

Luobitong Potentiates MTX’s Anti-Rheumatoid Arthritis Activity via Targeting Multiple Inflammatory Pathways

Serum retinol-binding protein 4 in stroke patients: correlation with T helper 17/regulatory T cell imbalance and 3-year cognitive function decline

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