Levels of Non Enzymatic Antioxidants in Down Syndrome

Abstract

Children with Down syndrome have elevated levels of oxidative stress . Hence antioxidant therapy can be beneficial among them.

Reduced salivary flow rate and high levels of oxidative stress in whole saliva of children with Down syndrome

“…, who used the same methodology as ours. On the other hand, conflicting results have demonstrated decreased values of TAOC in saliva and blood plasma of children with DS.…”

Antioxidants and biomarkers of oxidative damage in the saliva of patients with Down's syndrome

“…These findings are not consistent with others studies that found a significantly lower total antioxidant capacity in children with DS when compared to control. [45][46][47] In conclusion, saliva is an important tool for primary diagnosis of a possible systemic oxidative stress in patients with Down's syndrome. The present results showed a significant increase in salivary SOD concentration, MDA levels and total protein content in these patients.…”

The genomically mosaic brain: Aneuploidy and more in neural diversity and disease

“…SOD1 protects against the free radical superoxide anion O 2 − by reducing it to hydrogen peroxide (H 2 O 2 ) and O 2 in non-diseased individuals. The over-expression of SOD1 in DS is thought to create an imbalance in the free radical detoxication system leading to oxidative stress (OS) [115-117], which in turn promotes DNA damage and chromosomal nondisjunction that may lead to aneuploidy, and increased cell death contributing to abnormal brain development and mental retardation [114, 118, 119]. …”