Levels of Myeloperoxidase and Alkaline Phosphatase in Periimplant Sulcus Fluid in Health and Disease and After Nonsurgical Therapy

Malik, Nikita; Naik, Dilip G; Uppoor, Ashita

doi:10.1097/id.0000000000000277

Cited by 4 publications

(16 citation statements)

References 29 publications

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“…205,206 In peri-implant sulcus fluids, levels of MPO rose with the increase of pocket probing depth and increasing gingival inflammation but decreased significantly after non-surgical therapy. 207,208 Neutrophils, the first cellular responders to invading microbes, exert most of their antimicrobial activity in phagosomes, specialized membrane-bound intracellular compartments formed by ingestion of microorganisms. 209 Alternatively, stimulated neutrophils may combat microbes through the release of web-like filamentous structures of decondensed chromatin, socalled neutrophil extracellular traps.…”

Section: Mpomentioning

confidence: 99%

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Neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease

et al. 2015

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Cardiovascular diseases are chronic inflammatory diseases that affect a large segment of society. Coronary heart disease (CHD), the most common cardiovascular disease, progresses over several years and affects millions of people worldwide. Chronic infections may contribute to the systemic inflammation and enhance the risk for CHD. Periodontitis is one of the most common chronic infections that affects up to 50% of the adult population. Under inflammatory conditions the activation of endogenous degradation pathways mediated by immune responses leads to the release of destructive cellular molecules from both resident and immigrant cells. Matrix metalloproteinases (MMPs) and their regulators can activate each other and play an important role in immune response via degrading extracellular matrix components and modulating cytokines and chemokines. The action of MMPs is required for immigrant cell recruitment at the site of inflammation. Stimulated neutrophils represent the major pathogen-fighting immune cells that upregulate expression of several proteinases and oxidative enzymes, which can degrade extracellular matrix components (e.g. MMP-8, MMP-9 and neutrophil elastase). The activity of MMPs is regulated by endogenous inhibitors and/or candidate MMPs (e.g. MMP-7). The balance between MMPs and their inhibitors is thought to mirror the proteolytic burden. Thus, neutrophil-derived biomarkers, including myeloperoxidase, may activate proteolytic destructive cascades that are involved in subsequent immune-pathological events associated with both periodontitis and CHD. Here, we review the existing studies on the contribution of MMPs and their regulators to the infection-related pathology. Also, we discuss the possible proteolytic involvement and role of neutrophil-derived enzymes as an etiological link between chronic periodontitis and CHD.

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Section: Mpomentioning

confidence: 99%

Section: Mmps and Their Regulators In Periodontitis And Chdmentioning

confidence: 99%

Neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease

et al. 2015

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“…The characteristics of the included studies are summarized in Table 1 . All 17 included studies [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ] were published in English. Sample sizes ranged between 10 and 48 patients.…”

Section: Resultsmentioning

confidence: 99%

“…Sample sizes ranged between 10 and 48 patients. There were nine RCTs [ 13 , 17 , 18 , 20 , 22 , 23 , 25 , 27 , 29 ], six prospective case-control studies [ 14 , 16 , 19 , 21 , 24 , 28 ] and two case series [ 15 , 26 ].…”

Section: Resultsmentioning

confidence: 99%

“…The type of procedure included in the test groups for the treatment of peri-implantitis consisted of non-surgical mechanical debridement alone [ 16 , 21 ], non-surgical therapy with adjunctive use of lasers [ 13 , 23 , 26 , 28 ], non-surgical therapy with adjunctive use of antimicrobials, [ 13 , 18 , 20 , 22 , 24 ] access flap surgery alone [ 15 , 16 , 19 ], access flap with adjunctive antimicrobials [ 14 ] and access flap with EMD (Enamel Matrix Derivatives) [ 17 ]. In two studies, following induction of peri-implant mucositis, different formulations of toothpaste were assessed in terms of efficacy of the resolution of inflammation [ 25 , 27 ].…”

Section: Resultsmentioning

confidence: 99%

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Biomarker Expression of Peri-Implantitis Lesions before and after Treatment: A Systematic Review

Moaven

Giacaman

Beltrán

et al. 2022

IJERPH

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The need to predict, diagnose and treat peri-implant diseases has never been greater. We present a systematic review of the literature on the changes in the expression of biomarkers in peri-implant crevicular fluid (PICF) before and after treatment of peri-implantitis. Bacterial composition, clinical and radiographic parameters, and systemic biomarkers before and after treatment are reported as secondary outcomes. A total of 17 studies were included. Treatment groups were non-surgical treatment or surgical treatment, either alone or with adjunctive therapy. Our findings show that non-surgical treatment alone does not influence biomarker levels or clinical outcomes. Both adjunctive photodynamic therapy and local minocycline application resulted in a reduction of interleukin (IL)-1β and IL-10 twelve months after treatment. Non-surgical treatments with adjunctive use of lasers or antimicrobials were more effective at improving the clinical outcomes in the short-term only. Access flap debridement led to matrix metalloproteinase (MMP)-8 and tumour necrosis factor-α reduction twelve months post-surgery. Surgical debridement with adjunctive antimicrobials achieved a decrease in MMP-8 at three months. Adjunctive use of Emdogain™ (EMD) was associated with a reduction in 40 PICF proteins compared to access flap surgery alone. Surgical interventions were more effective at reducing probing pocket depth and bleeding on probing both in the short- and long-term. Surgical treatment in combination with EMD was found to be more effective in resolving inflammation up to twelve months.

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Selected osteointegration markers in different timeframes after dental implantation: findings and prognostic value

Bayandurov,

Orjonikidze,

Kraveishvili

et al. 2024

Acta Biochim. Pol.

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The study aimed to determine the osteointegration markers after dental implantation and evaluate their predictive value. The study was performed on 60 practically healthy persons who needed teeth rehabilitation using dental implants. The conical-shaped implants (CI) and hexagonal implants (HI) were used. The content of Osteopontin (OPN), Osteocalcin (OC), Alkaline Phosphatase (ALP), Osteoprotegerin (OPG), and nitric oxide (NO) was determined in patients’ gingival crevicular fluid (GCF) and peri-implant sulcular fluid (PISF), collected 1, 3, and 6 months after implantation. During the 3–6 months of observation level of OPN increased in patients with CIs (<50 years > 50 years) and HIs (<50 years) (CI: <50 years F = 36.457, p < 0.001; >50 years F = 30.104, p < 0.001; HI < 50 years F = 2.246, p < 0.001), ALP increased in patients with CIs (<50 years: F = 19.58, p < 0.001; >50 years: F = 12.01; p = 0.001) and HIs (<50 years) (F = 18.51, p < 0.001), OC increased in patients <50 years (CI: F = 33.72, p < 0.001; HI: F = 55.57, p < 0.001), but in patients >50 years - on the 3 days month (CI: F = 18.82, p < 0.001; HI: F = 26.26, p < 0.001), but sharply decreased at the end of sixth month. OPG increased during 1–3 months of the observation in patients <50 years (CI: F = 4.63, p = 0.037; HI: F = 2.8927, p = 0.046), but at the end of the sixth month returned to the initial level; NO content in PISF increased in patients with CI (>50 years) during 1–6 months of the observation (F = 27.657, p < 0.001). During the post-implantation period, age-related differences in osteointegration were observed. Patients <50 years old had relatively high levels of OPN, ALP, OC, and OPG in PISF, resulting in less alveolar bone destruction around dental implants and more intensive osteointegration. These indicators may be used as biological markers for monitoring implant healing. The process of osseointegration was more intense in CIs due to their comparatively high mechanical loading.

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Levels of Myeloperoxidase and Alkaline Phosphatase in Periimplant Sulcus Fluid in Health and Disease and After Nonsurgical Therapy

Abstract: Within confines of the study, it can be concluded that evaluation of biochemical markers in PISF can be a useful diagnostic tool to aid the clinician in decision making regarding the management of the condition.

Cited by 4 publications

References 29 publications

Neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease

Neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease

Biomarker Expression of Peri-Implantitis Lesions before and after Treatment: A Systematic Review

Selected osteointegration markers in different timeframes after dental implantation: findings and prognostic value

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