Levels of metabolic markers in drug-naive prediabetic and type 2 diabetic patients

Akour, Amal; Kasabri, Violet; Boulatova, Nailya; Bustanji, Yasser; Naffa, Randa; Hyasat, Dana; Khawaja, Nahla; Bustanji, Haidar; Zayed, Ayman A.; Momani, Munther

doi:10.1007/s00592-016-0926-1

Cited by 36 publications

(38 citation statements)

References 38 publications

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“…In PCOS patients, circulating ZAG levels were reported to be consistently reduced [10,27,28]. However, the relationship between circulating betatrophin levels and PCOS is controversial and the studies in the literature are inconsistent [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. Growing evidence indicates that these cytokines have some roles in the pathogenesis of T2DM and PCOS, and are also involved in IR development.…”

Section: Discussionmentioning

confidence: 99%

Several Circulating Biomarkers for PCOS Diagnosis

Luo

Zhang

et al. 2019

Exp Clin Endocrinol Diabetes

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Aims Irisin, Betatrophin and Zinc-α2-glycoprotein (ZAG) have been shown to be associated with insulin resistance (IR) and polycystic ovary syndrome (PCOS), respectively. The purpose of this study is to explore the potential accuracy of this combination of three cytokines in screening PCOS. Methods 186 individuals were recruited for this study. Circulating Irisin, Betatrophin and ZAG concentrations were measured by enzyme-linked immunosorbent assay. The association between these serum biomarkers and PCOS was assessed by logistic regression analysis. Receiver operating curve (ROC) analysis was performed to evaluate the diagnostic value of these biomarkers for PCOS women. Results In women with PCOS, serum Irisin and Betatrophin levels were markedly elevated compared to those in healthy controls (p<0.01), while ZAG levels were lower (p<0.01). PCOS women with IR (M-value<6.28) had lower circulating ZAG concentrations, and higher circulating Irisin and Betatrophin levels relative to PCOS women without IR (M-value ≥ 6.28). ROC curve analyses showed that the AUC for Irisin, ZAG and Betatrophin for predicting PCOS were 0.77, 0.83 and 0.85, respectively. In a joint ROC curves analysis of these serum markers and other parameters, the results showed that the AUC was 0.93, and the sensitivity and specificity were 82.1 % and 92.3 %, respectively. Conclusions When compared to using single cytokine, the analysis of Irisin, ZAG and Betatrophin elevates the accuracy in diagnosing PCOS.

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Section: Discussionmentioning

confidence: 99%

Several Circulating Biomarkers for PCOS Diagnosis

Luo

Zhang

et al. 2019

Exp Clin Endocrinol Diabetes

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“…On the other hand, a comprehensive meta-analysis by Li et al suggested that circulating betatrophin levels in T2D nonobese patients are higher than those in the nondiabetic control group [9]. Moreover, recent studies showed that plasma concentrations of metabolic markers, for example, betatrophin, as well as hepatocyte growth factor and nesfatin, are elevated in drugnaïve prediabetic and T2D patients in comparison to normoglycemic subjects [18,19]. It has also been observed that serum betatrophin concentration positively correlated with HbA1c and fasting plasma glucose in the group of patients with diabetes, prediabetic state, and metabolic syndrome [19] and with fasting plasma glucose and HOMA-IR in T2D and nondiabetic subjects [20].…”

Section: Introductionmentioning

confidence: 99%

Serum concentrations of betatrophin and its association with indirect indices of insulin resistance and beta cell function in women with polycystic ovary syndrome

Adamska¹,

Łebkowska²,

Jacewicz³

et al. 2017

EJEA

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Introduction. Data underline the role of betatrophin in glucose homeostasis. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance (IR). The aim of our study was to investigate the relationship of serum betatrophin concentrations with indirect indices of IR and insulin secretion in women with PCOS, compared to the control group. Methods. The study group comprised 43 women with PCOS and 16 controls. IR was assessed by HOMA-IR and Matsuda index. Insulin secretion was evaluated with HOMA-B. An oral glucose tolerance test (OGTT) with estimation of serum betatrophin concentrations was performed. Results. Glucose load resulted in an increase in serum betatrophin concentrations in the control group (p = 0 02). Serum betatrophin concentrations at 120 min of OGTT were lower in women with PCOS than in the control group (p = 0 02). We observed positive correlations between baseline serum betatrophin concentrations and HOMA-IR (r = 0 39, p = 0 008), negative correlations with Matsuda index (r = −0 31, p = 0 004), and a positive relationship with HOMA-B (r = 0 38, p = 0 01) in women with PCOS. Multiple regression analysis revealed that HOMA-B (β = 0 47, p = 0 001) was an independent factor connected to serum betatrophin levels in PCOS. Conclusions. Serum concentrations of betatrophin are connected with insulin resistance and beta cell function and did not change after glucose load in women with PCOS.

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“…The positive correlation of omentin-1 with HDL has been previously described in obesity, metabolic syndrome and cardiovascular disease. 30 However, the mechanism that explain these results was not clear. Most The mechanism for its elevation in obese patients was unclear but it was thought to be due to pro-inflammatory cytokines released from adipose tissue such as 1L-1 enhance intra-cellular zinc accumulation with intracellular copper efflux, and when released to blood it binds to ceruloplasmin.…”

Section: Discussionmentioning

confidence: 96%

The Relation of Omentin-1 Levels and Some Trace Elements as a Potential Markers for Diagnosis of Prediabetic Obese Patients

Ali

Rufaie

2019

Acta Chemica Iasi

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The obesity is one of the most common physiological disorders, also it is linked with a variety of circumstances like hypertension, dyslipidemia, T2DM, non-alcoholic fatty liver disease, and cardiovascular diseases. The aim of this study was to check the changes and compare serum omentin-1, lipid profile (TC, TG, VLDL-C, LDL-C, and HDL-C), trace elements (Mg, Zn, Cu, Fe) and insulin resistance between the prediabetic obese patients, healthy obese, and control subjects and assess the correlation between omentin-1, lipid profile, trace elements (Mg, Zn, Cu, Fe) levels and insulin resistance in prediabetic obese patients. Correlation analysis between omentin-1 levels with the biochemical parameters in the prediabetic obese patients with WC, body mass index, FBG, Insulin, HOMA-IR, HbA1c, TG, TC, LDL-C, VLDL-C, and copper was found to be negative; while significant positive correlation of omentin-1 with HDL-C, Mg, Zn, and Fe was noticed. Omentin-1 serum concentration level decrease and insulin resistance increased in prediabetic obese patients compared to healthy obese and control individuals. Omentin-1 inversely associated with obesity and insulin resistance, therefore can be used as a biomarker for obesity related metabolic disorders.

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Levels of metabolic markers in drug-naive prediabetic and type 2 diabetic patients

Cited by 36 publications

References 38 publications

Several Circulating Biomarkers for PCOS Diagnosis

Several Circulating Biomarkers for PCOS Diagnosis

Serum concentrations of betatrophin and its association with indirect indices of insulin resistance and beta cell function in women with polycystic ovary syndrome

The Relation of Omentin-1 Levels and Some Trace Elements as a Potential Markers for Diagnosis of Prediabetic Obese Patients

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