Levels of lipid peroxides and antioxidants in smokers and nonsmokers

Garg, N. K.; Singh, Raj Kumar; Dixit, Jaya; Jain, Amita; Tewari, Vandana

doi:10.1111/j.1600-0765.2006.00889.x

Cited by 65 publications

(67 citation statements)

References 25 publications

(18 reference statements)

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“…Smoking is associated with altered expression and activity of antioxidant enzymes. According to the studies [32,33] cigarette smoking is associated with a significant decrease in the level of SOD, however some other studies [34,35] have documented that compared to non smoker controls the bidi smokers have shown increased erythrocyte SOD activity. We have observed a relatively higher SOD Values are mean ± SD * P values are obtained using one way analysis of variance (ANOVA) with Tukey's correction for multiple group comparisons.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

et al. 2013

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The present study aims to assess and compare the biochemical oxidative stress markers in male smokers and non-smokers with chronic periodontitis. One hundred thirty-four male chronic periodontitis patients and 64 apparently healthy male volunteers were recruited for the study. The periodontal status was evaluated by measuring gingival index, plaque index, papillary bleeding index and clinical attachment loss using UNC-15 probe. The biochemical markers estimated were total antioxidant capacity, RBC-superoxide dismutase, glutathione peroxidase, vitamin C, malondialdehyde and C-reactive protein.The obtained results indicate higher oxidative stress in chronic periodontitis. Smokers with chronic periodontitis show significantly higher periodontal clinical parameters and relatively higher systemic oxidative stress. Vitamin C estimation may be an important biochemical parameter in conjunction with clinical parameters for diagnosis of chronic periodontitis in smokers.

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Section: Discussionmentioning

confidence: 99%

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

et al. 2013

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“…This interaction between pathogenic bacteria and the host immune response is accompanied by an increase in cytokine expression and immunological activity in gingival tissues (13). Thus, large amounts of pro-oxidants are produced in prolonged inflammatory response, as seen in periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress in Periodontitis

2012

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“…Garg et al [18] observed the delicate balance between ROS and tissue concentrations of antioxidants may be disturbed by various factors including smoking. Elevated levels of ROS stimulate neutrophils to upregulate the adhesion integrins, leading to their increased accumulation in tissues and a local sealing off of antioxidant enzymes, such as SOD, catalyse and protease inhibitors, as observed by Ryder et al [19].…”

Section: Discussionmentioning

confidence: 99%

Effect of Non-Surgical Periodontal Therapy on Superoxide Dismutase Levels in Gingival Tissues of Chronic Periodontitis Patients: A Clinical and Spectophotometric Analysis

2013

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Abstract. BACKGROUND: Superoxide dismutase (SOD), an antioxidant acting against superoxide (oxygen radical, O .−2 ), it is released in inflammatory pathways and causes connective tissue breakdown. Increased SOD activity in inflamed gingiva may indicate increased O .− 2 radical generation by neutrophils and other inflammatory cells at the diseased site. The aim of the study was to evaluate the effects of non-surgical periodontal therapy (NSPT) on SOD levels in gingival tissues of chronic periodontitis patients. METHODS: Forty subjects: 20 periodontally healthy (Control) and 20 chronic periodontitis (Test); age range 24-55 years were recruited. Gingival tissue samples were collected by excising the inner lining of the periodontal pocket at baseline (prior to non-surgical periodontal therapy) and 2 months post therapy. In controls, tissue samples were obtained immediately after tooth extraction scheduled for orthodontic reasons. Clinical parameters included probing depth, clinical attachment level, gingival index, bleeding index, plaque index. SOD activities were assessed spectrophotometrically at baseline and 2 months post NSPT, results were analysed statistically. RESULTS: At baseline, patients with chronic periodontitis had higher mean SOD activity (2.73 ± 1.36) than the control subjects (1.12 ± 1.13) with p = 0.00003 (p < 0.05). At 2 months post NSPT median SOD level (1.00) had come close to median SOD value of control group (0.85); p = 0.99 (p > 0.05). The resolution of inflammation with successful NSPT resulted in decreased SOD levels as in control group. Clinical parameters in patients with chronic periodontitis showed a significant improvement 2 months post NSPT (p < 0.05). CONCLUSION: Non-surgical periodontal therapy significantly improves the clinical parameters and restores previously increased SOD levels to normal in chronic periodontitis patients.

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Levels of lipid peroxides and antioxidants in smokers and nonsmokers

Abstract: The study results show that smoking increases the level of free radicals in periodontal tissues, which in turn may be responsible for the destruction seen in periodontal diseases.

Cited by 65 publications

References 25 publications

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

Oxidative Stress in Periodontitis

Effect of Non-Surgical Periodontal Therapy on Superoxide Dismutase Levels in Gingival Tissues of Chronic Periodontitis Patients: A Clinical and Spectophotometric Analysis

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