Levels of interleukin‐17 in gingival crevicular fluid and in supernatants of cellular cultures of gingival tissue from patients with chronic periodontitis

Abstract

The total amount of cytokine IL-17 in GCF samples and in the culture supernatants of gingival cells are significantly increased in periodontal disease.

The effect of periodontal scaling and root polishing on serum IL-17E concentrations and the IL-17A:IL-17E ratio

“…Furthermore, elevated levels of IL-17A have been detected in serum [6][7][8] saliva [8,9] and gingival crevicular fluid (GCF) [8,10,11] of periodontitis patients. Serum and GCF levels of IL-17A have also been demonstrated to correlate with clinical attachment loss in patients with chronic periodontitis [7,8,11] and aggressive periodontitis [7].…”

Niveles de interleukina 17 en el fluido gingival crevicular de pacientes con peridontitis crónica progresiva

“…La concentración de IL-17 en el FGC fue significativamente mayor en los sitios activos que en los sitios inactivos esto concuerda con los estudios de Vernal et al (17) que muestran que la concentración de IL-17 presente en el FGC de pacientes con periodontitis cróni-ca es significativamente mayor que en individuos sanos. Se ha demostrado que las células Th17 antagonizan con las células T reguladoras(Treg) por lo que amplifican la respuesta proinflamatoria y promueven la autoinmunidad.…”

Glycemic control and the production of cytokines in diabetic patients with chronic periodontal disease

“…Chronic periodontitis sites have shown increased levels of IL-17 in comparison with healthy periodontal tissues [18][19][20][21][22][23] and periodontal pathogens can stimulate the production of IL-17 from T-cells 19 . In this study, the concentration of the cytokine IL-17 was higher in patients with poorly controlled diabetes, confirming the Table 1.…”

“…These are powerful proinflammatory cells that produce interleukin IL-17 and stimulate fibroblasts, endothelial cells, macrophages and epithelial cells to produce multiple pro-inflammatory mediators, including IL-1, IL-6, tumour necrosis factor (TNF)-α and chemokines, resulting in the induction of inflammation 10 . High levels of IL-17 have been detected in biopsies of patients with chronic periodontitis 18 and the presence of Porphyromonas gingivalis was capable of stimulating T lymphocytes to produce IL-17 19 . Although the involvement of IL-17 in periodontal disease has been shown 18 , its role in the induction or progression of this disease is still unclear.…”

“…High levels of IL-17 have been detected in biopsies of patients with chronic periodontitis 18 and the presence of Porphyromonas gingivalis was capable of stimulating T lymphocytes to produce IL-17 19 . Although the involvement of IL-17 in periodontal disease has been shown 18 , its role in the induction or progression of this disease is still unclear. Therefore, it is important to understand the immune inflammatory mechanisms that are related to an increased susceptibility to periodontal disease in patients with type 2 diabetes in comparison with individuals without the disease 5,20 .…”