Levels of glutathione peroxidase, lipoperoxidase and some biochemical and haematological parameters in gazelles anaesthetised with a tiletamin–zolazepam–xylazine combination

Yaralioglu-Gurgoze, Sema; Şindak, Nihat; Şahin, Tekin; Çen, Osman

doi:10.1016/j.tvjl.2004.01.005

Cited by 11 publications

(8 citation statements)

References 6 publications

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“…However, other studies examining the use of tiletamine-zolazepam (Ceylan et al 2007) or its combination with xylazine in sheep (Aydilek 2007) and gazelles (Yaralioglu-Gurgoze et al 2005) demonstrated an increase in MDA concentrations, similar to the results of our study. Based on the fact that MDA is one of the end products of lipid peroxidation, and is both an indicator and effector of oxidative stress (Sivaci et al 2006) our study may support the fact that oxygen free radicals are released upon administration of TZXT.…”

Section: Discussionsupporting

confidence: 91%

“…In a previous study in sheep, tiletamine-zolazepam alone caused a significant decrease in Hb and PCV (Isaksson et al 2009). However, the combination of tiletaminezolazepam-xylazine had no effect on certain haematological indicators in dogs and gazelles (Yaralioglu-Gurgoze et al 2005). In the present study, RBC, PCV and Hb decreased gradually and returned to baseline levels after injection of TZXT.…”

Section: Discussioncontrasting

confidence: 69%

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Effects of the tiletamine/zolazepam-xylazine-tramadol combination on plasma oxidative status and haematological indicators in miniature pigs

Jiang

Fan

et al. 2014

Acta Vet. Brno

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Oxidative stress in the body occurs when the production of free radicals overwhelms the antioxidant defence systems. The aim of this study was to examine the effects of a tiletamine/ zolazepam-xylazine-tramadol combination on the antioxidant status, lipoperoxidase and blood cell indicators in eight miniature pigs. Baseline measures were recorded prior to anaesthesia, then the animals were anaesthetized with the combination of tiletamine/zolazepam (3.5 mg/kg), xylazine (1.32 mg/kg), and tramadol (1.8 mg/kg). Blood samples were collected from the anterior vena cava at 15, 30, 60, 90, 120 min, 24 h, and 72 h after anaesthesia. Plasma malondialdehyde, superoxide dismutase, catalase, and glutathione peroxidase concentrations were measured by colorimetry, and red blood cell counts, white blood cell counts, haemoglobin and packed cell volume were determined using an automated cell counter. The results showed that the concentration of malondialdehyde increased significantly at 30 and 60 min after the injection (P < 0.05), whereas glutathione peroxidase and catalase activity increased slightly (P > 0.05) then returned to baseline values after 90 min (P > 0.05). Superoxide dismutase activity increased significantly (P < 0.05) at 30 and 60 min, and then gradually decreased to baseline values after 90 min. Changes in red blood cell counts, haemoglobin and packed cell volume were not significant, while white blood cell count decreased significantly (P < 0.05) at 30 and 60 min. Our study is the first to demonstrate that tiletamine/zolazepam-xylazine-tramadol provide antioxidant effects, which may be proposed for alleviating the stress of examination and research at veterinary clinics or long-distance transportation.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 69%

Effects of the tiletamine/zolazepam-xylazine-tramadol combination on plasma oxidative status and haematological indicators in miniature pigs

Jiang

Fan

et al. 2014

Acta Vet. Brno

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“…The mechanisms of action of antioxidants may involve limiting the formation of free radicals through inhibition of lipid peroxidation and protein oxidation or the neutralisation of their toxic effects (Little and Gladen 1999). The pro-oxidation effects of some general anaesthetics have been described (Khinev doi: 10.17221/8420-VETMED et al 1994), and various anaesthetics possessing different physicochemical properties have been reported to affect the lipid peroxidation process directly or indirectly, leading to the formation of malondialdehyde (MDA) in the body or even to tissue damage (Yaralioglu-Gurgoze et al 2005).…”

mentioning

confidence: 99%

Effects of the dexmedetomidine, midazolam, butorphanol, and atropine combination on plasma oxidative status and cardiorespiratory parameters in raccoon dogs (Nyctereutes procyonoides)

Feng¹,

Hu²,

Zhang³

et al. 2015

Vet. Med. - Czech

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ABSTRACT:Oxidative stress in the body occurs when the production of free radicals overwhelms the antioxidant defence systems. This study aimed to investigate the effects of a combination of dexmedetomidine, midazolam, butorphanol, and atropine (DMBA) as an anaesthetic on plasma oxidative status in twelve raccoon dogs. Baseline measures were recorded prior to anaesthesia, and then the animals were anaesthetised with the combination of dexmedetomidine (25 µg/kg), midazolam (0.45 mg/kg), butorphanol (0.25 mg/kg), and atropine (0.035 mg/kg). Temperature, respiratory rate, haemoglobin saturation by oxygen, pulse rate, systolic arterial pressure, diastolic arterial pressure, and mean arterial pressure were continually monitored. Blood pressure was significantly decreased at 30 to 60 min (P < 0.05). Pulse rate ranged from 96 to 123 bpm, without episodes of severe bradycardia or tachycardia. Blood samples were collected from saphenous venipuncture at 0, 0.5, 1, and 24 h before, during, and after anaesthesia. Plasma superoxide dismutase, glutathione peroxidase, and catalase activity, and malondialdehyde concentrations were measured by colorimetry, and plasma vitamin E level was determined by high-performance liquid chromatography. Superoxide dismutase and glutathione peroxidase activities increased significantly (P < 0.05) at 0.5 h, and then gradually decreased to baseline values after 1 h. Catalase activity increased significantly (P < 0.05) at 0.5 h, 1 h, and then gradually decreased to baseline values after 24 h. There was no significant change in vitamin E level (P < 0.05).The concentration of malondialdehyde decreased significantly at 0.5, 1, and 24 h after injection (P < 0.05). The results show that the administered dose of dexmedetomidine, midazolam, butorphanol, and atropine has antioxidant effects in raccoon dogs. Our study is the first to demonstrate that dexmedetomidine, midazolam, butorphanol, and atropine exert antioxidant effects, which may be exploited to alleviate the stress of examination and research at veterinary clinics.

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“…The level of glucose increase has been described in dogs anaesthetized with enflurane (Naziroğlu and Gunay, 1999) and in gazelles anaesthetized with tiletamine-zolazepamxylazine (Yaralioglu-Gurgoze et al, 2005). Acute hyperglycaemia has been reported in cattle given xylazine, reflecting the inhibition of insulin release from the pancreatic  cells by the  2-adrenaergic receptors (Hsu and Hummel, 1981;Lemke, 2007).…”

Section: Discussionmentioning

confidence: 99%

Different fasting periods in tiletamine-zolezepam-anethetized cats: Glycemia, recovery, blood-gas and cardiorrespiratory parameters

Gering¹,

Nunes²,

Oliveira³

et al. 2013

Arq. Bras. Med. Vet. Zootec.

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Different fasting periods in tiletamine- ABSTRACTThe effects of different fasting periods on glycemia levels and on cardiorrespiratory parameters in tiletaminezolazepam-anesthetized cats were evaluated. Twenty one animals were randomly assigned to three groups: 8 hours (G8), 12 hours (G12) or 18 hours (G18) of the preoperative fasting. The tiletamine-zolazepam (2 mg/kg) was administered intravenously. The heart rate (HR), respiratory rate (f R ), rectal temperature (T R ), glycemia (G), laboratorial glycemia (G lab ), venous oxygen partial pressure (PvO 2 ), venous carbon dioxide partial pressure (PvCO 2 ), venous hemoglobin saturation (SvO 2 ), pH, base deficit (BD), bicarbonate concentration (HCO 3 -) and haematocrit were evaluated at 90 minutes after the last meal (T0), immediately before anesthesia (T1) and at ten (T2) and thirty (T3) minutes after tiletamine-zolezepam administration. The time between the administration of anesthetic and the cat's trial to elevate head (Th) and the interval between drug administration and aniamal's quadrupedal position (Tqp) were recorded. No differences among groups were recorded for glycemia, HR, PvO 2 , SvO 2 , pH, BD, HCO 3 -, Ht and Tqp. In G12 from T2, glycemia increased and from T1 PvCO 2 decreased. At T1, PvO 2 increased in all groups. In G8 and G12, from T1, DB and HCO 3 -decreased. In G12 and G18, from T2, Ht decreased. In G12, the Th mean was higher than G8. In conclusion, in tiletaminezolazepam-anesthetized cats, the different preoperative fasting did not influence glycemia, blood-gas and cardiorrespiratory parameters. Additionally, there was no relationship between glycemia and anesthesia recovery.

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Levels of glutathione peroxidase, lipoperoxidase and some biochemical and haematological parameters in gazelles anaesthetised with a tiletamin–zolazepam–xylazine combination

Cited by 11 publications

References 6 publications

Effects of the tiletamine/zolazepam-xylazine-tramadol combination on plasma oxidative status and haematological indicators in miniature pigs

Effects of the tiletamine/zolazepam-xylazine-tramadol combination on plasma oxidative status and haematological indicators in miniature pigs

Effects of the dexmedetomidine, midazolam, butorphanol, and atropine combination on plasma oxidative status and cardiorespiratory parameters in raccoon dogs (Nyctereutes procyonoides)

Different fasting periods in tiletamine-zolezepam-anethetized cats: Glycemia, recovery, blood-gas and cardiorrespiratory parameters

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