Levels of DDT, HCH, and HCB Residues in Human Blood in Ahmedabad, India

Bhatnagar, V. N.; Kashyap, Rekha; Zaidi, S. S. A.; Kulkarni, P. K.; Saiyed, H. N.

doi:10.1007/s00128-003-9049-9

Cited by 27 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…About 30% of the sample exceeded the tolerance limits of 10 lg/ L for HCH set out under the prevention of food adulteration Act (Dudani 1994). Levels of DDTs in the present study were similar to those in Madurai (8-26 lg/L) (Subramaniam and Solomon 2006), but levels of DDTs were lower than those reported in Lucknow (Kaphalia and Seth 1983), Delhi (710 lg/L) (Ramachandra et al 1984;Saxena et al 1987) and Ahmedabad (Bhatnagar et al 2004). Elevated level of DDTs have been found in human breast milk samples collected from major cities in India (Devanathan et al 2009), and other countries (Minh et al 2004).…”

Section: Resultssupporting

confidence: 53%

“…In India there are studies on the presence of organochlorine residues in human breast milk from the general population of different cities (Kumar et al 2006;Subramanian et al 2007) and from metropolitan (Devanathan et al 2009). However, there is little information available on human blood concentration (Bhatnagar et al 2004;Subramaniam and Solomon 2006). The present study was aimed to determine OCP in human blood samples of people engaged in agriculture and sheep wool work in neighborhood of Bangalore city, South India.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Organochlorine Pesticide Residues in Blood Samples of Agriculture and Sheep Wool Workers in Bangalore (Rural), India

Dhananjayan¹,

Ravichandran²,

Rajmohan³

2012

Bull Environ Contam Toxicol

View full text Add to dashboard Cite

To describe exposure level of organochlorine pesticides (OCP) among workers occupationally engaged in agriculture and sheep wool associated jobs, the present study was carried out in rural neighborhood of Bangalore city, India. Thirty participants were interviewed and obtained informed consent before blood sample collection. The maximum concentrations of OCP were detected in blood samples of agriculture workers than sheep wool workers. Among the metabolites of HCH and DDT, lindane (γ-HCH) and p,p'-DDE were the most contributed to the total OCP. There were no differences in pesticide residues found between sex and work groups. It was observed that about 30% of samples exceeded the tolerance limits of 10 μg/L prescribed for HCH under the prevention of food adulteration act. Therefore, the present study recommends continuous monitoring with larger sample size.

show abstract

Section: Resultssupporting

confidence: 53%

mentioning

confidence: 99%

Organochlorine Pesticide Residues in Blood Samples of Agriculture and Sheep Wool Workers in Bangalore (Rural), India

Dhananjayan¹,

Ravichandran²,

Rajmohan³

2012

Bull Environ Contam Toxicol

View full text Add to dashboard Cite

show abstract

“…HCH residues at many of the sites have percolated into the soil and thence contaminated groundwater (145). Residues of HCH isomers have now been reported for many countries in samples of air (76,79,138), water (8,71,139), soil (29,50,71,139,144), food commodities (7,17,175,184), milk (153,197), fish (44,87), and mammals (48) and even from human blood samples (15,169) and adipose tissue (14,73). Environmental residues from sites as remote from the major regions of production and use as the Arctic, Antarctic, and Pacific Ocean have been reported (63,185).…”

Section: Fig 2 Known Locations Of Hch Dumps In Excess Ofmentioning

confidence: 99%

“…The technology does depend on a liquid, or at least very moist, environment to allow the enzyme access to the substrate. Nevertheless, enzymatic bioremediants are now commercially available for the cleanup of certain pesticides in large-scale liquid wastes (1,15,28,154) and show promise for the treatment of various stockpiles, soils, and, in some cases, external surfaces of commodities (22,35). The good results for the enzymatic treatment of stockpiles are of particular interest with respect to very concentrated HCH deposits like dump sites, where microbial growth is severely limited by the availability of nutrients.…”

Section: Free-enzyme Bioremediationmentioning

confidence: 99%

Biochemistry of Microbial Degradation of Hexachlorocyclohexane and Prospects for Bioremediation

Lal

Pandey

Sharma

et al. 2010

Microbiol Mol Biol Rev

350

338

View full text Add to dashboard Cite

SUMMARY Lindane, the γ-isomer of hexachlorocyclohexane (HCH), is a potent insecticide. Purified lindane or unpurified mixtures of this and α-, β-, and δ-isomers of HCH were widely used as commercial insecticides in the last half of the 20th century. Large dumps of unused HCH isomers now constitute a major hazard because of their long residence times in soil and high nontarget toxicities. The major pathway for the aerobic degradation of HCH isomers in soil is the Lin pathway, and variants of this pathway will degrade all four of the HCH isomers although only slowly. Sequence differences in the primary LinA and LinB enzymes in the pathway play a key role in determining their ability to degrade the different isomers. LinA is a dehydrochlorinase, but little is known of its biochemistry. LinB is a hydrolytic dechlorinase that has been heterologously expressed and crystallized, and there is some understanding of the sequence-structure-function relationships underlying its substrate specificity and kinetics, although there are also some significant anomalies. The kinetics of some LinB variants are reported to be slow even for their preferred isomers. It is important to develop a better understanding of the biochemistries of the LinA and LinB variants and to use that knowledge to build better variants, because field trials of some bioremediation strategies based on the Lin pathway have yielded promising results but would not yet achieve economic levels of remediation.

show abstract

“…Regarding occurrence of OCP residues in blood, a number of studies have been reported for human beings (Walker et al 2003;Bhatnagar et al 2004;Waliszewski et al 2004;Mishra et al 2011) and the correlation between OCP residues and development of cancer, particularly breast cancer. Also, reports are also available about OC residues in blood of different animals and birds (Bustnes et al 2005) which indicate the exposure of living beings to the toxic compounds leading to their accumulation in blood.…”

mentioning

confidence: 99%

Persistent organochlorine pesticide residue in tissues and blood of goat

Singh

Nag

Singh

2014

Journal of Applied Animal Research

View full text Add to dashboard Cite

The production commensurate with the demand for animal products including meat is increasing due to urbanization and increase in per capita income. However, meat and meat products meant for human consumption should also be safe and free from toxic contaminants. Presence of any xenobiotics in human food web is undesirable and unacceptable particularly in the wake of sanitary and phytosanitary (SPS) measures and strict regulations imposed by many countries on the ground of safety of health of the consumers. In the present study, certain organochlorinated pesticide (OCP) residues in tissues and in blood samples of goat were determined. All samples were analysed for residues of hexachlorocyclohexane (HCH) isomers, dichlorodiphenyltrichloroethane (DDT) isomers and metabolites, endosulfan isomers and metabolite, aldrin, heptachlor and dicofol. The tissue samples were extracted in soxhlet with hexane-acetone (1:1) and cleaned up by florisil column chromatography. The analysis was performed in capillary gas chromatograph equipped with electron capture detector (GC-ECD). The result indicated that 40% tissue samples were contaminated with HCH residues, while DDT and endosulfan were present in 32% samples. In blood samples, no HCH residue could be detected, but DDT and endosulfan were present in 10% and 30% samples, respectively.

show abstract

Levels of DDT, HCH, and HCB Residues in Human Blood in Ahmedabad, India

Cited by 27 publications

References 0 publications

Organochlorine Pesticide Residues in Blood Samples of Agriculture and Sheep Wool Workers in Bangalore (Rural), India

Organochlorine Pesticide Residues in Blood Samples of Agriculture and Sheep Wool Workers in Bangalore (Rural), India

Biochemistry of Microbial Degradation of Hexachlorocyclohexane and Prospects for Bioremediation

Persistent organochlorine pesticide residue in tissues and blood of goat

Contact Info

Product

Resources

About