Levels of angiogenic markers in second-trimester maternal serum from in vitro fertilization pregnancies with oocyte donation

Dondik, Yelena; Pagidas, Kelly; Eklund, Elizabeth; Ngo, Christina; Palomaki, Glenn E.; Lambert‐Messerlian, Geralyn

doi:10.1016/j.fertnstert.2019.07.017

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…In these pregnancies, AFP levels are higher compared to pregnancies obtained from own oocytes (IVF and natural conception) regardless of the age of the oocyte donor or recipient. This is likely due to impaired implantation, immunoregulation and subsequent vascular disorders in the maternal-fetal unit of oocyte donor pregnancies, resulting in pregnancy pathologies such as pre-eclampsia (PE) or fetal growth restriction (FGR) [47,50].…”

Section: Oocyte Donationmentioning

confidence: 99%

Influence of selected factors on serum AFP levels in pregnant women in terms of prenatal screening accuracy — literature review

Głowska-Ciemny¹,

Szymański²,

Pankiewicz³

et al. 2023

Ginekol Pol

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Alpha-fetoprotein (AFP) is one of the biochemical components of the triple (T-3) and quadruple (T-4) test used so far in prenatal screening mainly for trisomy 21 (T21) and neural tube defects (NTDs). Based on many years of experience and data collected during these studies, a variety of factors have been identified that can affect a pregnant woman's serum AFP level, and thus the risk assessment of trisomy 21 (T21) and neural tube defects. These include both unaccounted for purely medical data (e.g., from baseline information about the patient, assisted reproduction methods used, comorbidities and emerging pregnancy pathologies) and errors made during statistical analysis. Since the triple or quadruple test is usually performed between 15 and 20 weeks of pregnancy, most scientific studies are based solely on results from this period of pregnancy -limited data are available for the first and third trimesters of pregnancy. In the era of new improved screening tests, AFP has the potential to become an independent marker for pregnancy well-being evaluation.

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Section: Oocyte Donationmentioning

confidence: 99%

Influence of selected factors on serum AFP levels in pregnant women in terms of prenatal screening accuracy — literature review

Głowska-Ciemny¹,

Szymański²,

Pankiewicz³

et al. 2023

Ginekol Pol

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“…На відміну від оцінки аналогічного параметру в І триместрі, вимірювання в терміні 16-18 +6 тижнів вагітності, виявило статистично достовірну різницю між показниками основної групи та групи порівняння -1,33±0,10 MoM та 1,09±0,07 MoM відповідно, p<0,05. Варто зазначити, що підвищення рівня даного показника серед пацієнток, залучених до програм ДРТ із донацією ооцитів (тобто також із формуванням алогенного плоду) порівняно з тими, у кого в рамках застосування ДРТ використовувалися власні ооцити, було виявлено дослідниками у 2019 році [5].…”

Section: Original Articlesunclassified

The features of the functioning of the fetoplacental complex in pregnant women with an allogeneic fetus

Romanenko,

Yesyp

2024

UJPP

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Aim - to determine the features of the functional state of the fetoplacental complex (FPC) in pregnant women with an allogeneic fetus and pregnant women who were involved in assisted reproductive technology (ART) programs using their own oocytes. Materials and methods. 77 pregnant women were examined. They were divided into two groups: Group I (main) - 39 women who became pregnant as a result of ART using donor oocytes with the formation of an allogeneic fetus; Group II (comparison) - 38 patients who became pregnant as a result of ART using their own oocytes. Statistical processing of research results was carried out using standard Microsoft Excel 5.0 and Statistica 6.0 programs. Results. Pregnant women with an allogeneic fetus are characterized by significantly lower levels of pregnancy-associated plasma protein-A (PAPP-A) and placental growth factor (PlGF), determined at 11-13+6 weeks of pregnancy, and human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) levels, measured at 16-18+6, compared with a group of women whose own oocytes were used as part of ART programs. In the women of Group I, significantly higher levels of systolic-to-diastolic ratio (SDR) and pulsatility index (PI) of both uterine arteries, resistance index (IR) of the left uterine artery at 20-24 weeks of pregnancy, as well as levels of PI and SDR of the umbilical artery, IR and PI of both uterine arteries and SDR determined for the left uterine artery at 28-31+6 weeks of pregnancy. In Group I, a significantly lower fetal abdominal circumference was found in comparison to Group II at 28-31+6 weeks of pregnancy. Conclusions. The presence of deviations in the indicators of FPC functioning among women of Group I indicates the need for further research of this problem and development of an improved surveillance program for pregnant women with an allogeneic fetus. The research was carried out in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Local Ethics Committee of the institution indicated in the work. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.

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Assisted Reproductive Technologies

Cantineau

Vrouwenraets

Montfoort

2021

Benirschke's Pathology of the Human Placenta

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Levels of angiogenic markers in second-trimester maternal serum from in vitro fertilization pregnancies with oocyte donation

Cited by 3 publications

References 27 publications

Influence of selected factors on serum AFP levels in pregnant women in terms of prenatal screening accuracy — literature review

Influence of selected factors on serum AFP levels in pregnant women in terms of prenatal screening accuracy — literature review

The features of the functioning of the fetoplacental complex in pregnant women with an allogeneic fetus

Assisted Reproductive Technologies

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