The features of the functioning of the fetoplacental complex in pregnant women with an allogeneic fetus

Abstract

Aim - to determine the features of the functional state of the fetoplacental complex (FPC) in pregnant women with an allogeneic fetus and pregnant women who were involved in assisted reproductive technology (ART) programs using their own oocytes. Materials and methods. 77 pregnant women were examined. They were divided into two groups: Group I (main) - 39 women who became pregnant as a result of ART using donor oocytes with the formation of an allogeneic fetus; Group II (comparison) - 38 patients who became pregnant as a result of ART using their own oocytes. Statistical processing of research results was carried out using standard Microsoft Excel 5.0 and Statistica 6.0 programs. Results. Pregnant women with an allogeneic fetus are characterized by significantly lower levels of pregnancy-associated plasma protein-A (PAPP-A) and placental growth factor (PlGF), determined at 11-13+6 weeks of pregnancy, and human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) levels, measured at 16-18+6, compared with a group of women whose own oocytes were used as part of ART programs. In the women of Group I, significantly higher levels of systolic-to-diastolic ratio (SDR) and pulsatility index (PI) of both uterine arteries, resistance index (IR) of the left uterine artery at 20-24 weeks of pregnancy, as well as levels of PI and SDR of the umbilical artery, IR and PI of both uterine arteries and SDR determined for the left uterine artery at 28-31+6 weeks of pregnancy. In Group I, a significantly lower fetal abdominal circumference was found in comparison to Group II at 28-31+6 weeks of pregnancy. Conclusions. The presence of deviations in the indicators of FPC functioning among women of Group I indicates the need for further research of this problem and development of an improved surveillance program for pregnant women with an allogeneic fetus. The research was carried out in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Local Ethics Committee of the institution indicated in the work. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.