Level of serum uric acid in patients with preeclampsia compared to controls and its relation to feto-maternal outcome

Abstract

Background: Uric acid is the final product of the purine metabolism in humans. The two final reactions in its production which catalyze the conversion of hypoxanthine to xanthine and the latter to uric acid are catalyzed by the enzyme xanthine oxidoreductase. The role of uric acid in the progression of prediabetes to diabetes has been known. Serum uric acid has been shown to be associated with cardiovascular disease, hypertension, and chronic kidney disease. The present study was done to see the level of uric acid in preeclampsia and healthy pregnant controls, to relate serum uric acid results to the severity of hypertension and its relation to fetomaternal outcome in patients attending OPD at RMC Ajmer. Methods: 100 cases of preeclampsia of age group between 20-40 year and gestational age ≥28 weeks and 100 normal healthy women with similar gestational age and age group were included in the study and maternal serum uric acid was estimated in both groups. Results: Mean serum uric acid levels in preeclampsia was 7.65±081 mg/dl and 3.21±072 mg/dl in control group. Perinatal complication was more in case group, 74 % were preterm compared to 11% in control group. Mean birth weight in study group was 2.07 kg, of which 24% babies were VLBW 52% were LBW, and 24% babies had normal birth weight, in control group mean birth weight was 2.82 kg. The difference was found to be statistically significant (p value 0.001). In the study group, the MSUA concentration is found higher in LBW and VLBW babies compared to normal birth weight babies. Conclusions: There is a positive correlation between SUA & severity of preeclampsia, and a significant adverse fetal outcome is observed with raised MSUA in preeclamptic patients.

Serum uric acid levels as a biomarker for perinatal outcomes among mothers with pre- eclampsia in Tanzania

“…In addition, the study found that 12.3% of neonates were admitted in the neonatal intensive care unit. These ndings did not match with other studies done by Meena et al, India and Zangana et al, Iraq reporting a proportion of 34% and 57.48% NICU admissions respectively (13,15) Moreover, the proportion of deliveries before 37weeks of gestation in our study was found to be 70.9% among the subjects with hyperuricemia. This nding seem to be quite comparable with the proportion of preterm delivery 75.6% found in Maternity teaching hospital in Erbil, but in contrary to 43.2% by study done in Vietnam (9,13).…”

Correlation of Maternal Serum Uric Acid Level and Feto-maternal Outcome in Hypertensive Disorder of Pregnancy: A Prospective Study

“…This is consistent with the study done by Meena R et al, which showed that hyperuricemia in patients with hypertensive disorders during pregnancy was a strong risk factor for several maternal complications. [18] In the study done by Kumar and Singh, it was observed that a high uric acid level was associated with increased severity of the disease and adverse maternal outcomes. [7] Similarly, Kondareddy and Prathap have also shown that an increase in uric acid level is associated with increasing severity of pregnancy-induced hypertension like eclampsia, abruptio and HELLP syndrome.…”

Level of Uric Acid in Women Suffering from Pre-Eclampsia and its Comparison with Normal Pregnancy

“…18 A case control study from Ajmer observed marked difference between serum acid level in pregnant patients had pre-eclampsia and females with healthy pregnancy respectively 7.65 [+ or -] 081 mg/dl and 3.21 [+ or -] 072 mg/dl, (p value 0.001). 19 An outpatient department study was conducted at our fellow institution. They found significantly elevated level of serum uric acid in 63% pregnant women with pre-eclampsia in 3 rd trimester.…”