2019
DOI: 10.1007/s10620-019-05783-4
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Leuprolide Acetate, a GnRH Agonist, Improves the Neurogenic Bowel in Ovariectomized Rats with Spinal Cord Injury

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Cited by 8 publications
(3 citation statements)
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“…In vitro experiments with culture of rat embryonic spinal cord neurons, it has been observed that incubation with GnRH induces a significant neuritic growth, as well as an increase in the expression of neurofilaments presenting a neurotrophic effect [5]. Likewise, the administration of LA improves the neurogenic bowel conditions caused by spinal cord injury in rats, indicating an effect on the peripheral nerve [6]. According to this background, it is possible that the treatment with LA induces a recovery in the peripheral nerves through the trophic effect on the neurofilaments, since these determine the axonal diameter and thus increase its conduction velocity.…”
Section: Discussionmentioning
confidence: 99%
“…In vitro experiments with culture of rat embryonic spinal cord neurons, it has been observed that incubation with GnRH induces a significant neuritic growth, as well as an increase in the expression of neurofilaments presenting a neurotrophic effect [5]. Likewise, the administration of LA improves the neurogenic bowel conditions caused by spinal cord injury in rats, indicating an effect on the peripheral nerve [6]. According to this background, it is possible that the treatment with LA induces a recovery in the peripheral nerves through the trophic effect on the neurofilaments, since these determine the axonal diameter and thus increase its conduction velocity.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, it is important to develop novel neuroprotective or neuroregenerative treatments for mild HIE. Previously, it has been reported the effect of the leuprolide acetate (LA), an agonist of the gonadotropin releasing hormone (GnRH), as a neuroregenerative [8][9][10] and immunomodulator [11] in other nervous system injuries. The objective of this study was to evaluate the immunomodulatory effect of LA in the acute phase of mild HIE and its effects in motor and behavior in a subacute phase of the mild HIE.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, chronic administration of GnRH or leuprolide acetate (LA)-a GnRH analog-for 5 weeks consistently improved urodynamic parameters and sensorimotor function in rats with SCI (Calderón-Vallejo and Quintanar, 2012;Calderón-Vallejo et al, 2015;Díaz Galindo et al, 2015). In humans, the presence of GnRH receptor (GnRHR) in spinal cord tissue has been confirmed and it is proposed that some of the beneficial actions observed in SCI rats and patients treated with LA are, at least, partially mediated through local GnRHR activation (Quintanar et al, 2018;Altamira-Camacho et al, 2020;Díaz-Galindo et al, 2021).…”
Section: Introductionmentioning
confidence: 99%