2023
DOI: 10.1159/000533388
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Effect of Leuprolide Acetate, a GnRH Agonist, on Neuroinflammation and Anxiety-Like Behavior after Mild Hypoxic-Ischemic Encephalopathy in Rat Model

Karina Alejandra Pedroza-García,
Denisse Calderón-Vallejo,
Daniel Cervantes-García
et al.

Abstract: Background: Mild hypoxic-ischemic encephalopathy (HIE) is a condition that predisposes to negative outcomes such as neuroanatomical injury, mood disorders, and motor or cognitive disabilities. The neuroinflammation plays an important role in the neurological damage; therefore, reducing it could provide neuroprotection. The leuprolide acetate (LA) has shown to have neuroregenerative and immunomodulator properties in other nervous system injuries. Objective: The aim of this study was to evaluate the immunomodula… Show more

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