Leukotrienes cause eosinophil emigration into conjunction tissue

Spada, Clayton S.; Woodward, DF; Hawley, Stephen B.; Nieves, Amelia L.

doi:10.1016/0090-6980(86)90181-4

Cited by 43 publications

(22 citation statements)

References 38 publications

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“…41,42 In addition, conjunctival administration of LTB4, as well as LTC4 and LTD4, induces vessel vasodilatation, oedema, hyperaemia, and leucocyte and eosinophilic infiltration of the conjunctiva. [43][44][45] The biological activities of leukotrienes on the conjunctiva may contribute to the presence of the characteristic symptoms observed in VKC, such as mucous secretion, conjunctival hyperaemia, and chemosis.…”

Section: Vernal Keratoconjunctivitis S Bonini Et Al 346mentioning

confidence: 99%

Vernal keratoconjunctivitis

Bombardieri

Coassin

Aronni

et al. 2004

Eye

242

244

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Vernal keratoconjunctivitis (VKC) is an allergic eye disease that especially affects young boys. The most common symptoms are itching, photophobia, burning, and tearing. The most common signs are giant papillae, superficial keratitis, and conjunctival hyperaemia.Patients with VKC frequently have a family or medical history of atopic diseases, such as asthma, rhinitis, and eczema. However, VKC is not associated with a positive skin test or RAST in 42-47% of patients, confirming that it is not solely an IgE-mediated disease. On the basis of challenge studies as well as immunohistochemical and mediator studies, a Th2-driven mechanism with the involvement of mast cells, eosinophils, and lymphocytes has been suggested. Th2 lymphocytes are responsible for both hyperproduction of IgE (interleukin 4, IL-4) and for differentiation and activation of mast cells (IL-3) and eosinophils . Other studies have demonstrated the involvement of neural factors such as substance P and NGF in the pathogenesis of VKC, and the overexpression of oestrogen and progesterone receptors in the conjunctiva of VKC patients has introduced the possible involvement of sex hormones. Thus, the pathogenesis of VKC is probably multifactorial, with the interaction of the immune, nervous, and endocrine systems.The clinical management of VKC requires a swift diagnosis, correct therapy, and evaluation of the prognosis. The diagnosis is generally based on the signs and symptoms of the disease, but in difficult cases can be aided by conjunctival scraping, demonstrating the presence of infiltrating eosinophils. Therapeutic options are many, in most cases topical, and should be chosen on the basis of the severity of the disease. The most effective drugs, steroids, should however be carefully administered, and only for brief periods, to avoid secondary development of glaucoma.A 2% solution of cyclosporine in olive oil or in castor oil should be considered as an alternative. The long-term prognosis of patients is generally good; however 6% of patients develop corneal damage, cataract, or glaucoma.

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Section: Vernal Keratoconjunctivitis S Bonini Et Al 346mentioning

confidence: 99%

Vernal keratoconjunctivitis

Bombardieri

Coassin

Aronni

et al. 2004

Eye

242

244

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“…Cysteinyl leukotrienes (LTs) can stimulate the proliferation of eosinophil hematopoietic progenitor cells and play a role in leukocyte migration from bone marrow to the circulation [9,10,11]. Cysteinyl LTs are chemoattractants for eosinophils and can increase eosinophil survival time [11,12,13]. Eosinophil superoxide anion generation is induced by LT D 4 [14].…”

Section: Introductionmentioning

confidence: 99%

Effect of Montelukast Monotherapy on Oxidative Stress Parameters and DNA Damage in Children with Asthma

Dilek

Özkaya²,

Koçyiğit³

et al. 2015

Int Arch Allergy Immunol

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Background: There is ample knowledge reported in the literature about the role of oxidative stress in asthma pathogenesis. It is also known that the interaction of reactive oxygen species with DNA may result in DNA strand breaks. The aim of this study was to investigate if montelukast monotherapy affects oxidative stress and DNA damage parameters in a population of pediatric asthma patients. Methods: Group I consisted of 31 newly diagnosed asthmatic patients not taking any medication, and group II consisted of 32 patients who had been treated with montelukast for at least 6 months. Forty healthy control subjects were also enrolled in the study. Plasma total oxidant status (TOS) and total antioxidant status (TAS) were measured to assess oxidative stress. DNA damage was assessed by means of alkaline comet assay. Results: The patients in both group I and group II had statistically significant higher plasma TOS (13.1 ± 4 and 11.1 ± 4.1 μmol H₂O₂ equivalent/liter, respectively) and low TAS levels (1.4 ± 0.5 and 1.5 ± 0.5 mmol Trolox equivalent/liter, respectively) compared with the control group (TOS: 6.3 ± 3.5 μmol H₂O₂ equivalent/liter and TAS: 2.7 ± 0.6 mmol Trolox equivalent/liter; p < 0.05). DNA damage was 18.2 ± 1.0 arbitrary units (a.u.) in group I, 16.7 ± 8.2 a.u. in group II and 13.7 ± 3.4 a.u. in the control group. There were statistically significant differences only between group I and the control group (p < 0.05). Conclusions: According to the findings, montelukast therapy makes only minimal but not statistically significant improvement in all TOS, TAS and DNA damage parameters.

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“…Other mediators released by mast cells include arachidonic acid, eosinophilic chemo tactic factor [Butrus, 1987], platelet-activating factor [Braquet, 1987), tryptase [Spada, 1986], and chymase [Schechter, 1986]. The metabolism of arachidonic acid results in the production of prostaglandins and le ukotrienes.…”

Section: Other Mediatorsmentioning

confidence: 99%

“…Tryptase is a tetrameric serine endoprotease that is stored in its active form in mast cells. Although its physiologic role is not yet understood, its regional specificity for mast cells makes it an excellent marker [Spada, 1986). Chymase, another serine endoprotease, is also stored in its active form in mast cells [Schechter, 1986].…”

Section: Other Mediatorsmentioning

confidence: 99%

Comparison of the Conjunctival Allergen Challenge Model with the Environmental Model of Allergic Conjunctivitis

Abelson

1999

Acta Ophthalmologica Scandinavica

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Leukotrienes cause eosinophil emigration into conjunction tissue

Cited by 43 publications

References 38 publications

Vernal keratoconjunctivitis

Vernal keratoconjunctivitis

Effect of Montelukast Monotherapy on Oxidative Stress Parameters and DNA Damage in Children with Asthma

Comparison of the Conjunctival Allergen Challenge Model with the Environmental Model of Allergic Conjunctivitis

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