Effect of Montelukast Monotherapy on Oxidative Stress Parameters and DNA Damage in Children with Asthma

Dilek, Fatih; Özkaya, Enis; Koçyiğit, Abdürrahim; Yazıcı, Mebrure; Kesgin, Siddika; Gedik, Ahmet Hakan; Çakır, Erkan

doi:10.1159/000436967

Cited by 11 publications

(10 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22 However, our recent study showed that montelukast monotherapy does not overcome the oxidative stress produced by asthma in children. 23 In the study by Nadeem et al, plasma total antioxidant capacity and total protein sulfhydryls were found to be decreased in acute exacerbations of asthma compared to stable asthmatic patients. However, this work does not include a control group of healthy participants.…”

Section: Discussionmentioning

confidence: 95%

Plasma total thiol pool in children with asthma: Modulation during montelukast monotherapy

Dilek

Özkaya

Koçyiğit

et al. 2015

Int J Immunopathol Pharmacol

Self Cite

View full text Add to dashboard Cite

Background: Inflammation, which is a hallmark of asthma, is one of the main sources of oxidative stress in the human body. Thiols are powerful antioxidants that protect cells against the consequences of oxidative stress. We aimed to investigate whether asthma and montelukast monotherapy affect the total plasma thiol pool in children. Methods: A total of 60 children with asthma and 35 healthy controls participated in the study. Group I consisted of newly diagnosed asthmatics who did not have regular anti-asthmatic therapy previously. Group II consisted of patients who had been undertaking montelukast monotherapy regularly for at least 4 months. Plasma total antioxidant status (TAS) and plasma total thiol (PTT) were measured using spectrophotometric methods. In addition, the median TAS and PTT levels for groups I and II were not statistically different (P >0.05). There was a positive correlation between TAS and PTT levels (rho = 0.38, P <0.05) in group I. Conclusion: In order to balance the oxidative stress, both TAS and PTT which are markers of the antioxidant system are reduced in children with asthma. Montelukast monotherapy can limit oxidative stress and thus restore PTT levels but not TAS levels in asthmatic children.

show abstract

Section: Discussionmentioning

confidence: 95%

Plasma total thiol pool in children with asthma: Modulation during montelukast monotherapy

Dilek

Özkaya

Koçyiğit

et al. 2015

Int J Immunopathol Pharmacol

Self Cite

View full text Add to dashboard Cite

show abstract

“…We did not find any difference in plasma TOS, TAS, OSI levels, and UAS7 score between boys and girls ( p > 0.05). We excluded patients with concomitant asthma, allergic rhinitis, and atopic dermatitis from the study, because there are some studies showing that all these diseases are associated with elevated oxidative stress [ 22 – 24 ]. However, the frequency of concomitant allergic diseases in our CSU group was not significantly higher when compared to prevalence rates of allergic diseases in our city.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress in Children with Chronic Spontaneous Urticaria

Dilek

Özçeker

Özkaya

et al. 2016

Oxidative Medicine and Cellular Longevity

Self Cite

View full text Add to dashboard Cite

The pathogenesis of chronic spontaneous urticaria (CSU) has not been fully understood; nevertheless, significant progress has been achieved in recent years. The aim of this study was to investigate the possible role of reactive oxygen species (ROS) in the pathogenesis of CSU. Sixty-two children with CSU and 41 healthy control subjects were enrolled in the study. An extensive evaluation of demographic and clinical features was done, and serum oxidative stress was evaluated by plasma total oxidant status (TOS) and total antioxidant status (TAS) measurements. The median value of plasma TOS was found to be 10.49 μmol H2O2 equiv./L (interquartile range, 7.29–17.65) in CSU patients and 7.68 μmol H2O2 equiv./L (5.95–10.39) in the control group. The difference between the groups was statistically significant (p = 0.003). Likewise, the median plasma TAS level in the CSU group was decreased significantly compared to that of the control group (2.64 [2.30–2.74] versus 2.76 [2.65–2.86] mmol Trolox equiv./L, resp., p = 0,001). Our results indicated that plasma oxidative stress is increased in children with CSU when compared to healthy subjects, and plasma oxidative stress markers are positively correlated with disease activity.

show abstract

“…There are no clinical trial data to support the use of antioxidants to prevent asthma or allergy development (54). Other than corticosteroids, which possess antioxidant and anti-inflammatory properties, other anti-asthmatic drugs, e.g., montelukast, did show conflicting results regarding their capacity to improve total antioxidant status and decrease oxidative damage (55, 56). …”

Section: Antioxidant Strategies For Asthma Treatmentmentioning

confidence: 99%

Oxidative Stress and Bronchial Asthma in Children—Causes or Consequences?

2017

View full text Add to dashboard Cite

Bronchial asthma is one of the most common chronic inflammatory diseases of the airways. In the pathogenesis of this disease, the interplay among the genes, intrinsic, and extrinsic factors are crucial. Various combinations of the involved factors determine and modify the final clinical phenotype/endotype of asthma. Oxidative stress results from an imbalance between the production of reactive oxygen species and reactive nitrogen species and the capacity of antioxidant defense mechanisms. It was shown that oxidative damage of biomolecules is strongly involved in the asthmatic inflammation. It is evident that asthma is accompanied by oxidative stress in the airways and in the systemic circulation. The oxidative stress is more pronounced during the acute exacerbation or allergen challenge. On the other hand, the genetic variations in the genes for anti-oxidative and pro-oxidative enzymes are variably associated with various asthmatic subtypes. Whether oxidative stress is the consequence of, or the cause for, chronic changes in asthmatic airways is still being discussed. Contribution of oxidative stress to asthma pathology remains at least partially controversial, since antioxidant interventions have proven rather unsuccessful. According to current knowledge, the relationship between oxidative stress and asthmatic inflammation is bidirectional, and genetic predisposition could modify the balance between these two positions—oxidative stress as a cause for or consequence of asthmatic inflammation.

show abstract

Effect of Montelukast Monotherapy on Oxidative Stress Parameters and DNA Damage in Children with Asthma

Cited by 11 publications

References 40 publications

Plasma total thiol pool in children with asthma: Modulation during montelukast monotherapy

Plasma total thiol pool in children with asthma: Modulation during montelukast monotherapy

Oxidative Stress in Children with Chronic Spontaneous Urticaria

Oxidative Stress and Bronchial Asthma in Children—Causes or Consequences?

Contact Info

Product

Resources

About