Leukotriene receptor antagonists: Efficacy and safety in children with asthma

Effect of secondhand cigarette smoke, RSV bronchiolitis and parental asthma on urinary cysteinyl LTE4

“…37 Asthma symptoms improve after administration of a cysLT receptor antagonist. 38 Thus the reason for SHS worsening these diseases may also be due to a ''double hit'' of cysLTs.…”

Effect of secondhand cigarette smoke, RSV bronchiolitis and parental asthma on urinary cysteinyl LTE4

“…37 Asthma symptoms improve after administration of a cysLT receptor antagonist. 38 Thus the reason for SHS worsening these diseases may also be due to a ''double hit'' of cysLTs.…”

RCT of Montelukast as Prophylaxis for Upper Respiratory Tract Infections in Children

“…It is well tolerated in young children. 10 It is an effective treatment of asthma [11][12][13][14][15][16][17][18] and allergic rhinitis in adult and pediatric patients. 19,20 Infections with viruses causing URI, such as influenza A, rhinovirus, and respiratory syncytial virus (RSV), increase leukotriene levels in nasal secretions.…”

Exercise-Induced Asthma in Children

“…The leukotriene receptor antagonists appear to be well tolerated in children even with daily use for up to 6 months. [77] The leukotriene receptor antagonist montelukast has been studied for the treatment of exercise-induced bronchoconstriction in patients with mild asthma and EIA in a randomized controlled trial. [78] The study included participants ≥15 years of age, with a median age in the active and placebo arm of 25 years.…”

Effect of secondhand cigarette smoke, RSV bronchiolitis and parental asthma on urinary cysteinyl LTE4

“…37 Asthma symptoms improve after administration of a cysLT receptor antagonist. 38 Thus the reason for SHS worsening these diseases may also be due to a ''double hit'' of cysLTs.…”

RCT of Montelukast as Prophylaxis for Upper Respiratory Tract Infections in Children

“…It is well tolerated in young children. 10 It is an effective treatment of asthma [11][12][13][14][15][16][17][18] and allergic rhinitis in adult and pediatric patients. 19,20 Infections with viruses causing URI, such as influenza A, rhinovirus, and respiratory syncytial virus (RSV), increase leukotriene levels in nasal secretions.…”

Exercise-Induced Asthma in Children

“…The leukotriene receptor antagonists appear to be well tolerated in children even with daily use for up to 6 months. [77] The leukotriene receptor antagonist montelukast has been studied for the treatment of exercise-induced bronchoconstriction in patients with mild asthma and EIA in a randomized controlled trial. [78] The study included participants ≥15 years of age, with a median age in the active and placebo arm of 25 years.…”

Effect of secondhand cigarette smoke, RSV bronchiolitis and parental asthma on urinary cysteinyl LTE4

“…37 Asthma symptoms improve after administration of a cysLT receptor antagonist. 38 Thus the reason for SHS worsening these diseases may also be due to a ''double hit'' of cysLTs.…”

RCT of Montelukast as Prophylaxis for Upper Respiratory Tract Infections in Children

“…It is well tolerated in young children. 10 It is an effective treatment of asthma [11][12][13][14][15][16][17][18] and allergic rhinitis in adult and pediatric patients. 19,20 Infections with viruses causing URI, such as influenza A, rhinovirus, and respiratory syncytial virus (RSV), increase leukotriene levels in nasal secretions.…”

Exercise-Induced Asthma in Children

“…The leukotriene receptor antagonists appear to be well tolerated in children even with daily use for up to 6 months. [77] The leukotriene receptor antagonist montelukast has been studied for the treatment of exercise-induced bronchoconstriction in patients with mild asthma and EIA in a randomized controlled trial. [78] The study included participants ≥15 years of age, with a median age in the active and placebo arm of 25 years.…”