Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation

Jang, Jae Hyun; Park, Donghwan; Park, Guen soo; Kwak, Dong Wook; Park, Jae In; Yu, Dae Yeul; You, Hye Jin; Kim, Jae Hong

doi:10.1038/s12276-021-00682-z

Cited by 8 publications

(6 citation statements)

References 53 publications

(44 reference statements)

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“…In recent years, many studies have demonstrated that immune function, inflammation, and tumor occurrence are closely related. For instance, immune-related factors can affect the tumor microenvironment and promote tumorigenesis ( 11 , 12 ). Based on preoperative blood values detected by standard laboratory tests, preoperative immune indicators, including LMR, PLR, and NLR, are used because they can predict the presence of malignant tumors, such as lung cancer and prostate cancer, and predict the survival of patients ( 13 , 14 ).…”

Section: Discussionmentioning

confidence: 99%

Blood immune indexes can predict lateral lymph node metastasis of thyroid papillary carcinoma

et al. 2022

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ObjectiveTo explore the clinical significance of blood immune indexes in predicting lateral lymph node metastasis (LLNM) of thyroid papillary carcinoma (PTC).MethodsThe pathological data and preoperative blood samples of 713 patients that underwent thyroid surgery at affiliated Hangzhou First People’s Hospital Zhejiang University School of Medicine from January 2013 to June 2021 were collected as the model group. The pathological data and preoperative blood samples of 177 patients that underwent thyroid surgery in the same hospital from July 2021 to October 2021 were collected as the external validation group. Univariate and multivariate logistic regression analyses were used to determine the independent risk factors of LLNM in PTC patients. A predictive model for assessing LLNM in PTC patients was established and externally validated using the external data.ResultsAccording to univariate and multivariate logistic regression analyses, tumor diameter (P < 0.001, odds ratios (OR): 1.205, 95% confidence interval (CI): 1.162–1.249) and the preoperative systemic immune-inflammation index (SII) (P = 0.032, OR: 1.001, 95% CI: 1.000–1.002) were independent risk factors for distinguishing LLNM in PTC patients. When the Youden index was the highest, the area under the curve (AUC) was 0.860 (P < 0.001, 95% CI: 0.821–0.898). The externally validated AUC was 0.827 (P < 0.001, 95% CI: 0.724–0.929), the specificity was 86.4%, and the sensitivity was 69.6%. The calibration curve and the decision curve indicated that the model had good diagnostic value.ConclusionBlood immune indexes can reflect the occurrence of LLNM and the biological behavior of PTC. The predictive model established in combination with SII and tumor diameter can effectively predict the occurrence of LLNM in PTC patients.

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Section: Discussionmentioning

confidence: 99%

Blood immune indexes can predict lateral lymph node metastasis of thyroid papillary carcinoma

et al. 2022

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“…By binding to its receptor BLT 2 , LTB 4 stimulates IL-8 production and promotes metastasis of breast cancer cells in concert with NF-KB (20). Lipids catalyzed by 5-LO and 12-LO also promotes lung tumor cell proliferation and the production of IL-6, another important in ammatory mediator of the TME (21). Our results have rst provided preliminary evidence that leukotriene B4 promotes glioma.…”

Section: Discussionmentioning

confidence: 54%

ALOX5 and ALOX5AP as an mRNA metric predicts unfavorable prognosis in lower-grade glioma

Ping

Yang

2023

Preprint

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The role of leukotrienes in glioma remains less understood. In this study, we explore the prognostic implication of leukotriene biosynthesis-related genes ALOX5 and ALOX5AP in lower-grade glioma (LGG) associated molecular underpinnings. The average expression of ALOX5 and ALOX5AP is defined as the ALOX score, which was positively associated with the malignant phenotype of LGG. Kaplan-Meier analysis and Cox regression analysis disclose that an increased expression of the ALOX score predicts an unfavorable outcome, and acts as an independent risk factor. Besides, a tumor microenvironment characterized by a high ALOX score contains more innate immune cells and an active inflammatory response than the ALOX score low group. At single-cell resolution, ALOX5 and ALOX5AP were predominantly expressed by tumor-associated macrophages (TAMs). The ALOX score gives a good performance in predicting immunosuppressive cell gene signature especially myeloid-derived suppressor cells and T-cell dysfunction. Together, these results provide preliminary evidence of the role of leukotriene biosynthesis genes in the glioma microenvironment and may offer a novel therapeutic target for LGG.

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“…Leukotriene B4 receptor 2 (LTB4R2), a g-protein-coupled receptor regulates chemotaxis and wound healing. Its expression has been associated with invasion and metastasis of lung cancer and breast cancer [15] [16]. It was also confirmed that high expression of LTB4R2 promoted CRC cell proliferation [17].…”

Section: Discussionmentioning

confidence: 74%

Screening of Colon Cancer Apoptosis-Related Genes Based on Bioinformatics and Construction of Survival Prognostic Model

Zhao¹,

Wu²,

Xu³

et al. 2023

JBM

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This study aimed to explore the prognostic value of Anoikis-related genes (ANRGs) in colon cancer using bioinformatics and construct a prognostic model based on ANRGs. ANRGs integrated from GeneCard and Harmonizome were used to identify CRC subtypes and construct a prognostic model for CRC patients. The immune microenvironment (TME) between different subtypes was also investigated. Finally, a line chart based on ANRGs was provided for clinical use, and decision curve analysis (DCA) was performed to determine the potential benefits of the model for clinical strategies. We identified 14 differential expression genes (DEGs) related to survival in CRC Anoikis, and selected 7 genes to construct the prognostic model. The prognostic risk score was determined as independent prognostic factor. Functional analysis showed that high-risk and low-risk groups had different immune infiltration status. Combined with CRC clinical pathological characteristics, a line chart was constructed, and DCA analysis showed that this model could benefit from clinical treatment strategies. This study explored 7 prognostic-associated risk genes related to CRC and constructed a line chart, which can provide important reference value for clinical doctors to choose personalized treatment for CRC patients.

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Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation

Cited by 8 publications

References 53 publications

Blood immune indexes can predict lateral lymph node metastasis of thyroid papillary carcinoma

Blood immune indexes can predict lateral lymph node metastasis of thyroid papillary carcinoma

ALOX5 and ALOX5AP as an mRNA metric predicts unfavorable prognosis in lower-grade glioma

Screening of Colon Cancer Apoptosis-Related Genes Based on Bioinformatics and Construction of Survival Prognostic Model

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