Leukodepletion filters reduce <i>Leishmania</i> in blood products when used at collection or at the bedside

Cardo, Lisa J.; Salata, Jeanne; Harman, Ronald; Mendez, J.; Weina, Peter J.

doi:10.1111/j.1537-2995.2006.00821.x

Cited by 26 publications

(29 citation statements)

References 22 publications

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“…With a very low prevalence in Western Countries there is currently no donor screening for both of them. However, transfusion-transmitted infection by Leishmania or Trypanosoma seems to be successfully prevented by leukoreduction [32], [33].…”

Section: Parasitesmentioning

confidence: 99%

Transfusion-transmissible infections and transfusion-related immunomodulation

Buddeberg

Schimmer

Spahn

2008

Best Practice & Research Clinical Anaesthesiology

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Transfusion-transmissible infections and transfusion-related immunomodulation AbstractThe risk of acquiring a transfusion-transmitted infection has declined in recent years. However, after human immunodeficiency virus and hepatitis B and C virus transmission were successfully reduced, new pathogens are threatening the safety of the blood supply, especially in the face of rising numbers of immunocompromised transfusion recipients. Despite new standards in the manufacture and storage of blood products, bacterial contamination still remains a considerable cause of transfusion-related morbidity and mortality. Better allograft survival in kidney transplant patients and higher cancer recurrence rate in surgical oncology patients after allogeneic blood transfusions highlighted a previously underestimated side-effect: transfusion-related immunomodulation (TRIM). The precise pathomechanism still remains uncertain; however, its mostly deleterious effects--such as a higher incidence of postoperative or nosocomial infections--is increasingly accepted. Although transfusion-related immunomodulation is thought to be mediated mainly by donor white blood cells, the benefit of leukoreduction on overall mortality and on infectious complications is highly debatable. Transfusion-transmissible infections and Transfusion-related immunomodulation Transfusion-transmissible infections and Transfusion-related immunomodulation AbstractThe risk of acquiring a transfusion-transmitted infection has declined in recent years.

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Section: Parasitesmentioning

confidence: 99%

Transfusion-transmissible infections and transfusion-related immunomodulation

Buddeberg

Schimmer

Spahn

2008

Best Practice & Research Clinical Anaesthesiology

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“…Nevertheless, although the leukodepletion system leads to a reduction in parasite detection, the existence of different filtration systems makes further research necessary to determine the efficacy of leukodepletion, with particular regard to other blood components, as well as to determine the usefulness of other methods to remove or inactivate the parasite in blood. In any case, the relatively low number of recently reported cases of TTL in nonendemic areas of Europe might be explained by the widespread use of leukodepletion filters in these regions [110,112].…”

Section: Preventionmentioning

confidence: 92%

“…In this context, the use of this and other blood protection procedures would be considered mandatory in the case of recipients with co-infections and/or immune-suppression, which appear as aggravating factors triggering greater morbidity. In addition, to complete this complex decision, the high cost of hospitalization for patients with VL cannot be ignored, coupled with the low availability of beds in public hospitals, and the toxicity of drugs used in the treatment [44,48,110].…”

Section: Preventionmentioning

confidence: 99%

“…At this time, considering that all the parasites should be contained within monocytes, there is a direct correlation between the ability of the filter to remove leukocytes and parasite depletion. However, the possible presence of free amastigotes, due to WBC breakdown during filtration, which could survive outside the cells in blood stored at 4 C, may increase the risk of transmission [23,30,110,111].…”

Section: Preventionmentioning

confidence: 99%

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Transfusion transmitted leishmaniasis. What to do with blood donors from endemic areas?

Mansueto

Seidita

Vitale

2014

Travel Medicine and Infectious Disease

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Summary Leishmaniasis clinical spectrum ranges from cryptic infection to fatal visceral leishmaniasis. Cryptic infection can be found in blood donors from areas endemic for leishmaniasis all over the world. Although leishmaniasis is a classic vector-borne disease, cases of transfusion transmitted leishmaniasis have been reported especially in nonendemic areas. Most of these cases regarded infants or children. This paper reviews the literature on this specific feature and the impact of leishmaniasis on transfusion medicine. Relevant literature was found through PubMed. The reference lists of selected articles identified further sources. Conclusions: Blood donations by emigrants or travelers from endemic areas require special attention. Routine diagnostic methods should be implemented in blood banks to exclude donors that are positive for Leishmania, and individuals who suffered from visceral leishmaniasis should be prohibited from donating blood. The use of leukodepletion filters at the time of collection should be recommended in at-risk areas especially for high-risk recipients. ª

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“…These transmissions are avoidable if the appropriate precautionary measures are observed. Leishmania agents are enriched in leucocytes [43]. They can be transmitted by red blood cells, granulocytes and platelet concentrates.…”

Section: A 35 Transmissibilitymentioning

confidence: 99%

Arboprotozoae

2009

Transfus Med Hemother

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Leukodepletion filters reduce Leishmania in blood products when used at collection or at the bedside

Cited by 26 publications

References 22 publications

Transfusion-transmissible infections and transfusion-related immunomodulation

Transfusion-transmissible infections and transfusion-related immunomodulation

Transfusion transmitted leishmaniasis. What to do with blood donors from endemic areas?

Arboprotozoae

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