Leukocytic Response As a Monitor of Immunodepression in Burn Patients

McCabe, W. Peter

doi:10.1001/archsurg.1973.01350140021008

Cited by 19 publications

(1 citation statement)

References 13 publications

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“…In the human, surgical trauma has been found to cause depression of the primary antibody response (Alexander and Montcrieff, 1966) and inhibition of the migration of lymphocytes and monocytes into inflamed areas (McCabe et al, 1973). When the lymphocytes are removed from such patients, a depressed mitotic response to plant lectins and allogenic cells has been reported (Slade et al, 1975) together with an inhibition of the release of leu- (1986) have reported that lymphocytes obtained from untreated depressed patients who were not suffering from any apparent physical illness also showed a marked suppression of the mitogenic response to plant lectins.…”

Section: Opioidsmentioning

confidence: 99%

Psychoneuroimmunology: An area of interest for the psychopharmacologist?

Leonard¹

1990

J Psychopharmacol

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Anecdotal evidence suggesting a causal relationship between psychiatric illness, environmental stress and a malfunctioning immune system goes back to antiquity. Recently, clinical and experimental studies have established the interrelationship between neuro- endocrine regulation, the immune system and abnormalities in central neurotransmission which may be deranged as a consequence of stressful events. This short review is an attempt to assess the evidence implicating altered immune responsiveness in depression and to consider the impact of different types of environmental stress in triggering the immune malfunction. While these findings are of considerable biological importance, it is presently unclear whether the immunological changes are primary or secondary to the disease states.

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Section: Opioidsmentioning

confidence: 99%