Abstract:Tests for leukoagglutinins and lymphocytotoxic antibodies were performed on sera from 34 recipients of 78 transfusions of leukocytes obtained from donors with chronic myelogenous leukemia. The presence of preformed leukocyte alloantibodies directed against donor cells predisposed to transfusion reactions of variable severity and failure of the transfused cells to survive and circulate in their new host. Studies in vitro demonstrated that these antibodies could inhibit granulocyte phagocytosis and bactericidal … Show more
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