Determinants of the efficacy of prophylactic granulocyte transfusions: A meta-analysis

Vamvakas, Eleftherios C.; Pineda, Alvaro A.

doi:10.1002/(sici)1098-1101(1997)12:2<74::aid-jca4>3.0.co;2-6

Cited by 72 publications

(23 citation statements)

References 41 publications

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“…9 We looked at neither the prevalence of alloimmunization nor the compatibility between the patients and the granulocyte units for transfusion. A potential confounding factor is the time effect.…”

Section: Discussionmentioning

confidence: 99%

Granulocyte Transfusion Therapy in Pediatric Patients After Hematopoietic Stem Cell Transplantation

Pham

Rogoza

Stotler

et al. 2012

Journal of Pediatric Hematology/Oncology

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Section: Discussionmentioning

confidence: 99%

Granulocyte Transfusion Therapy in Pediatric Patients After Hematopoietic Stem Cell Transplantation

Pham

Rogoza

Stotler

et al. 2012

Journal of Pediatric Hematology/Oncology

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“…There is renewed interest in the use of granulocytes for transfusion therapy, with recognition that the most effective treatments are associated with higher doses of cells 2,5,17 . Therefore, it is vital that the most stimulative and effective reagents be used for the apheresis collection procedure.…”

Section: Discussionmentioning

confidence: 99%

“…The use of granulocyte transfusions is increasing and is finding particular application in the treatment of life‐threatening bacterial and fungal infections in immunosuppressed patients 1–3 . It is known that the effectiveness of the preparation is related to the number of cells in the component transfused 4,5 .…”

mentioning

confidence: 99%

An in vitro method for predicting the efficacy of WBC separation using different starch preparations and anticoagulant ratios

Rock

Berger²,

Romans³

et al. 2000

Transfusion

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“…The results of the trials and the subsequent availability of growth factors probably contributed to the decline of this practice [63]. A 1997 meta-analysis concluded that prophylactic GTX could “no longer be recommended”, arguing that the the effect on prevention of infections detected by the first studies would be negligible in the presence of more effective antibiotics and colony growth factors [64]. …”

Section: Gtx For Prophylaxis Of Infectionmentioning

confidence: 99%

Granulocyte transfusions: A concise review for practitioners

Gea-Banacloche

2017

Cytotherapy

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Granulocyte transfusions (GTXs) have been used to treat and prevent infections in neutropenic patients for more than 40 years, despite persistent controversy regarding their efficacy. This narrative review attempts to complement recent systematic reviews by the Cochrane Collaboration and provide both historical context and critical assessment of the most significant clinical studies published over the years. The data suggest that properly collected and promptly infused granulocytes are active against infections, both bacterial and fungal. The most important question that remains unanswered is in which patients the administration of granulocytes will be beneficial. The preponderance of evidence suggests that granulocyte transfusions may be efficacious in few select cases as a temporizing measure to control an infection that is expected (or proven) to be refractory to optimal antimicrobial treatment, and that could otherwise be controlled by marrow recovery, which is expected to happen. In this regard, they are best considered a “bridge” that grants enough time for the recipient to develop their own response to the infection. The challenges to use GTXs successfully are both clinical, in terms of timely identifying the patients who may benefit, and logistical, in terms of optimal selection of donors and collection technique.

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Determinants of the efficacy of prophylactic granulocyte transfusions: A meta-analysis

Cited by 72 publications

References 41 publications

Granulocyte Transfusion Therapy in Pediatric Patients After Hematopoietic Stem Cell Transplantation

Granulocyte Transfusion Therapy in Pediatric Patients After Hematopoietic Stem Cell Transplantation

An in vitro method for predicting the efficacy of WBC separation using different starch preparations and anticoagulant ratios

Granulocyte transfusions: A concise review for practitioners

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