Leukocyte mobilization to skin lesions, determination of cell surface receptors () and phagocytic capacities of neutrophils in dogs with chronic deep pyoderma

Wisselink, M. A.; Kessel, Kok P. M. van; Willemse, Ton

doi:10.1016/s0165-2427(97)00008-1

Cited by 10 publications

(6 citation statements)

References 21 publications

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“…Moreover, the results demonstrate a high percentage of granulocytes with CD11b integrins in healthy dogs, which confirms the data reported by Ruaux and Williams (13). Surface receptors of CD11b and CD11/18 integrins present on granulocytes are considered to be the indicators of adhesion and migration of these cells during inflammation (13,19). Hence, a significant decrease in CD11b integrins on granulocytes of dogs with AD complicated by purulent skin inflammation observed in the study indicates the impaired phagocytic activity.…”

Section: Discussionsupporting

confidence: 90%

“…Furthermore, the findings demonstrate that the expression of β2 integrins on monocytes in dogs with complicated AD depended on the severity of symptoms, and was higher in dogs with deep purulent dermatitis. Taking into account that in dogs with AD deep pyoderma is chronic and results from surface or superficial inflammation, increased percentages of monocytes with β2 integrins found in the study indicate their involvement in phagocytosis and cytotoxicity of staphylococcal infection (1,19). Moreover, the results demonstrate a high percentage of granulocytes with CD11b integrins in healthy dogs, which confirms the data reported by Ruaux and Williams (13).…”

Section: Discussionsupporting

confidence: 89%

“…These integrins are mainly responsible for adhesion of neutrophils to endothelial cells, their passage through the blood vessel wall, and phagocytosis of immune complexes and microorganisms (1,13). The CD11b/18 receptor dysfunction has been demonstrated in peripheral blood neutrophils of dogs with chronic purulent dermatitis and in Irish Setters with leukocyte adhesion deficiency (LAD) (6,19).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of CD11b and CD11/18 integrin expression on leukocytes of dogs with atopic dermatitis

Taszkun

2014

Bulletin of the Veterinary Institute in Pulawy

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Cytometric analysis was performed in order to detect the expression of surface molecules CD11b and CD11/18 on lymphocytes, granulocytes, and monocytes of peripheral blood of dogs with atopic dermatitis (AD) complicated by purulent dermatitis. The percentage of peripheral blood lymphocytes with CD11b and CD11/18 was found to be significantly higher (P < 0.05) in dogs with AD than in healthy dogs. The percentage of granulocytes expressing CD11b molecule was significantly lower in dogs with complicated AD compared to healthy dogs and dogs with uncomplicated AD. The expression of CD11b and CD11/18 integrin on monocytes of dogs with complicated AD depended on the severity of symptoms and was higher in dogs with deep purulent dermatitis. It was concluded that the expression of CD11b and CD11/18 integrin on leukocytes of dogs with AD depends on the stage of the disease.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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Assessment of CD11b and CD11/18 integrin expression on leukocytes of dogs with atopic dermatitis

Taszkun

2014

Bulletin of the Veterinary Institute in Pulawy

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“…Chemotaxis and killing capacities of neutrophilic leukocytes were undisturbed. 18 IgG, IgGab, IgGd, IgM and IgA levels were elevated and there was no evidence for complement de®ciency.…”

Section: Discussionmentioning

confidence: 94%

German Shepherd dog pyoderma: a prospective study of 23 cases

Denerolle

Bourdoiseau²,

Magnol³

et al. 1998

Veterinary Dermatology

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Twenty-three German Shepherd dogs aected with recurrent deep pyoderma (GSP) were studied prospectively. After selection according to inclusive and exclusive criteria, parameters of humoral and cellmediated immunity were examined. Radial immunodiusion showed high levels of IgG and low levels of IgA. Peripheral blood lymphocytes were analysed by¯ow cytometry. The CD8 subpopulation was abnormally elevated, while the CD4 cell subpopulation was decreased. German Shepherd pyoderma is thus associated with immunological factors.

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“…A form of immunodeficiency disorder has been suspected but its nature has proven difficult to determine. For example, recurrent deep pyoderma has not been associated with functional disturbances in peripheral and lesional neutrophils, 87,88 although lymphocyte blastogenesis may be depressed 86,89 . Serum antibody concentrations may show high levels of IgG and low levels of IgA; together with elevations in the number of circulating CD8 cells and a decrease in CD4 (T lymphocytes) and CD21 (B lymphocytes) cells 90,91 .…”

Section: Canine Pyodermamentioning

confidence: 99%

Immunomodulation and immunodeficiency

Foster¹

2004

Veterinary Dermatology

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This article briefly reviews the concepts of immunodeficiency and immunomodulation as they relate to selected skin diseases in the dog and cat. Immunodeficiency states are uncommon and may be associated with a subnormal or down-regulated immune system, including humoral deficiencies, such as IgA, and abnormal lymphocyte or neutrophil function. Establishing a causal relationship between a skin disease and presumed immunodeficient state has been difficult due to the rarity of such conditions, and the limited nature of the techniques used to characterise the immune system response. Severe combined immunodeficiency in dogs is a well characterised primary immunodeficiency state involving lymphocytes; retrovirus infection in cats may lead to an acquired immunodeficient state with some association with certain dermatological conditions although it remains unclear that infection is causally linked with disease. Immunomodulation usually implies stimulating the immune system along a beneficial pathway. Such a therapeutic approach may involve a wide variety of agents, for example intravenous immunoglobulin. There are few randomised controlled trials with veterinary patients that unequivocally demonstrate beneficial responses to immunomodulatory agents. Interferons are cytokines of major interest in human and veterinary medicine for their antiviral, anti-tumour and immunomodulatory effects. The advent of veterinary-licensed products containing recombinant interferon may enable demonstration of the efficacy of interferons for conditions such as canine papillomatosis and feline eosinophilic granuloma complex. Canine pyoderma has been treated with a number of presumed immunomodulatory agents with limited success. With more detailed knowledge of the pathogenesis of pyoderma it may be possible to develop efficacious immunomodulators.

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Leukocyte mobilization to skin lesions, determination of cell surface receptors () and phagocytic capacities of neutrophils in dogs with chronic deep pyoderma

Cited by 10 publications

References 21 publications

Assessment of CD11b and CD11/18 integrin expression on leukocytes of dogs with atopic dermatitis

Assessment of CD11b and CD11/18 integrin expression on leukocytes of dogs with atopic dermatitis

German Shepherd dog pyoderma: a prospective study of 23 cases

Immunomodulation and immunodeficiency

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