Twenty-three German Shepherd dogs aected with recurrent deep pyoderma (GSP) were studied prospectively. After selection according to inclusive and exclusive criteria, parameters of humoral and cellmediated immunity were examined. Radial immunodiusion showed high levels of IgG and low levels of IgA. Peripheral blood lymphocytes were analysed by¯ow cytometry. The CD8 subpopulation was abnormally elevated, while the CD4 cell subpopulation was decreased. German Shepherd pyoderma is thus associated with immunological factors.
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