Leukocyte count and C reactive protein as diagnostic factors in febrile convulsion

Biyani, Garima; Ray, Supratim; Chatterjee, Kripasindhu; Sen, Sukanta; Mandal, Pradyut Kumar; Mukherjee, M. K.

doi:10.3126/ajms.v8i2.16331

Cited by 5 publications

(5 citation statements)

References 6 publications

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“…Also, serum neuroglobin levels were positively correlated with TLC. This was in agreement with Biyani et al 15 who found that TLC increases after rigorous muscle contractions, so it was hypothesized that elevation of white blood cells after a seizure is a result of muscular activity and due to epinephrine release and demargination of neutrophils.…”

Section: Discussionsupporting

confidence: 91%

Neuroglobin and Prolactin As Potential Biomarkers for Differentiating Epileptic versus Nonepileptic Paroxysmal Disorders in Children

Mahgoob

Moussa

2020

Journal of Pediatric Epilepsy

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At least 20% of patients referred to pediatric epilepsy centers with the suspicion of epileptic seizures actually have other conditions. Neuroglobin is a new globin member which is highly expressed in the central and peripheral nervous systems. We aim to evaluate usefulness of neuroglobin to differentiate between epilepsy and other conditions that mimic epilepsy. Our study was conducted on 90 children divided into three groups: 30 patients with epileptic seizures, 35 children with nonepileptic paroxysmal disorder, and 25 apparently healthy, age and sex-matched children as a normal control. Complete blood count, blood chemistries including random blood glucose, calcium, sodium, in addition to serum prolactin, and neuroglobin were performed for all children. The study showed a significant increase of both serum neuroglobin and prolactin levels in epileptic group compared with nonepileptic paroxysmal disorder and control groups (p < 0.01). Serum neuroglobin showed 95% sensitivity and 95.7% specificity in the diagnosis of generalized seizures. Serum neuroglobin may be a promising novel marker to differentiate epileptic versus nonepileptic disorders in children in the emergency setting, when history and clinical presentation are equivocal.

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Section: Discussionsupporting

confidence: 91%

Neuroglobin and Prolactin As Potential Biomarkers for Differentiating Epileptic versus Nonepileptic Paroxysmal Disorders in Children

Mahgoob

Moussa

2020

Journal of Pediatric Epilepsy

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“…In our study there was significant higher level in TLC (7.75 ± 1.2) in febrile convulsions than fever without convulsions with no difference with idiopathic epilepsy. In line of our study Biyani et al and Liu et al (26,27) they found significant increase in leukocyte count level in febrile convulsions than control groups. In contrary to our result Stöcklin et al and Hashim et al (28,29) found that there was insignificant difference in TLC between febrile convulsions and control febrile group.…”

Section: Discussionsupporting

confidence: 86%

Copeptin as a Serum Biomarker for Febrile Convulsions

2021

Aswan University Medical Journal

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Background: Febrile convulsions are the most common neurologic disorder in the pediatric age group, affecting 2-5% of children between 6 months and 5 years of age. Objective: We conducted the present acase control study in order to investigate whether copeptin can be considered as a biomarker for febrile convulsions and its relation with idiopathic convulsions. Patients and methods: The present study included 105 children with either febrile convulsions, fever or had epilepsy who were recruited from Pediatric department at Aswan University Hospital. Results: There was statistically significant increase in copeptin level in febrile convulsions compared to fever without convulsions and idiopathic epilepsy. There was statistically significant increase in temperature in febrile convulsions than other groups and in fever without convulsions than idiopathic epilepsy. There was statistically significant decrease in hemoglobin (p <0.001), MCV (p <0.001), HCT (p <0.001), in febrile convulsions compared with other groups. There was statistically significant decrease in serum Na in febrile convulsions and idiopathic epilepsy compared to fever without convulsion. Conclusion: The present study showed that serum copeptin was a significant discriminator of febrile convulsion from idiopathic epilepsy and fever without convulsions.

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“…patients and the rest 29 (36.25 %) had normal leucocyte count similar to the study of Biyani et al [18], in which when they compared Febrile convulsion (FC) and non-febrile convulsion children, they encountered a significant increase of WBC (p=0.0005) in children with FS, measured at the time of admission which is similar to the present study as 45/80 (56.25%) patients had increased WBC count.…”

Section: Priyanishaben Et Alsupporting

confidence: 90%

Clinical Profile of Children With Febrile Seizure in a Teaching Hospital

PRIYANISHABEN,

KHAN,

Patil

2023

Asian J Pharm Clin Res

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Objectives: To find out the clinical feature and outcomes of febrile seizures. Methods: After written informed consent, detailed clinical history of each patient including a time of presentation, the onset of fever and associated symptoms, data regarding demographic details, duration and type of seizure, history of seizures, and antiepileptic drug, repetition of seizure within 24 h, past history of seizures, birth history, family history was taken and entered in predesigned pro forma. Collected data were checked and verified for correctness and accuracy, which was then analyzed using statistical methods. Results: In the present study male-to-female ratio was 1.75:1. The maximum number (82.5%) of patients lacked a family history of febrile seizure, while 17.5% of patients had a positive family history of FS. 70% of the pediatric patients had upper respiratory tract infection. The maximum number of patients had simple febrile seizures, which are 81.25%, whereas 18.75% of patients had complex febrile seizures. The majority (73.75%) of patients in the present study had anemia. WBC count >11×109/L was found in 45 patients out of 80 (56.25%), and WBC count<4.5×109/L was found in 6 out of 80 (7.5%). Conclusion: Majority of patients with febrile seizures presented at a younger age which might represent the vulnerability of the developing brain to fever. As all the patients were discharged without any complication, so this study further adds to the knowledge of the benign nature of this disease.

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Leukocyte count and C reactive protein as diagnostic factors in febrile convulsion

Cited by 5 publications

References 6 publications

Neuroglobin and Prolactin As Potential Biomarkers for Differentiating Epileptic versus Nonepileptic Paroxysmal Disorders in Children

Neuroglobin and Prolactin As Potential Biomarkers for Differentiating Epileptic versus Nonepileptic Paroxysmal Disorders in Children

Copeptin as a Serum Biomarker for Febrile Convulsions

Clinical Profile of Children With Febrile Seizure in a Teaching Hospital

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