Leukocyte adhesion molecules in transplantation11In collaboration with The American Physiological Society, Thomas E. Andreoli, MD, Editor

Rabb, Hamid; Bonventre, Joseph V.

doi:10.1016/s0002-9343(99)00199-0

Cited by 9 publications

(1 citation statement)

References 61 publications

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“…Intercellular adhesion molecule-1 (ICAM-1, CD54, ICAM1 gene located on 19 th chromosome, locus 19p13.3-p13.2) is an immunoglobulin expressed on endothelial cells, smooth muscle cells, macrophages and activated lymphocytes. Intercellular adhesion molecule-1 plays a crucial role in initiating the immunological response through the adhesion of circulating leukocytes to the blood vessel wall and transendothelial migration to tissue [12]. Vascular adhesion molecule-1 (VCAM-1, CD106, VCAM1 gene located on primer of the 1 st chromosome, locus 1p31-32) is present on the endothelium and antigen-presenting cells.…”

Section: Introductionmentioning

confidence: 99%

Correlation between ICAM1 and VCAM1 gene polymorphisms and histopathological changes in kidney allograft biopsies

Domański¹,

Kłoda²,

Pawlik³

et al. 2013

aoms

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IntroductionThe immunoglobulin-like molecules intercellular adhesion molecule-1 (ICAM-1) and vascular adhesion molecule-1 (VCAM-1) are responsible for endothelial cell-leukocyte adhesion followed by transmigration of leukocytes through the endothelial cell lining. The aim of this study was to examine the correlation between polymorphisms in ICAM1 and VCAM1 genes and histopathological changes in transplanted kidney biopsies.Material and methodsThe study enrolled 82 Caucasian renal transplant recipients (48 males, 34 females). Genotyping of the rs5498 ICAM1 and the rs1041163 and rs3170794 VCAM1 gene polymorphisms was performed using real-time polymerase chain reaction (PCR). Biopsies were performed in 82 patients and were reviewed by a renal pathologist and the Banff working classification criteria were used.ResultsThere were no significant associations between VCAM gene polymorphisms and histopathological changes in kidney allograft biopsies. ICAM1 gene polymorphism was associated with the grade of interstitial fibrosis. Interstitial fibrosis was more severe among individuals with the G allele than those with the A allele (AA vs. GG+AG, p = 0.017). There were no statistically significant associations between ICAM1 gene polymorphism and other histopathological changes in kidney allograft biopsies.ConclusionsThe results of our study suggest that rs5498 ICAM1 gene polymorphism is associated with the grade of interstitial fibrosis in kidney recipients and the changes are more severe in patients with the G allele.

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Section: Introductionmentioning

confidence: 99%