Correlation between ICAM1 and VCAM1 gene polymorphisms and histopathological changes in kidney allograft biopsies

Domański, Leszek; Kłoda, Karolina; Pawlik, Andrzej; Wiśniewska, Magda; Kwiatkowska, Ewa; Kurzawski, Mateusz; Safranow, Krzysztof; Ciechanowski, Kazimierz

doi:10.5114/aoms.2012.29218

Cited by 12 publications

(8 citation statements)

References 30 publications

(23 reference statements)

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“…A biopsy is the gold standard for diagnosing kidney allograft disorders as it allows the verification of the probable causes of organ function deterioration. Therefore biopsies are performed in kidney recipients with DGF or suspected AR to assess the extent of chronic rejection [15]. The Banff working classification criteria are currently used to assess renal transplant pathology and facilitate the selection of appropriate treatments [16].…”

Section: Discussionmentioning

confidence: 99%

IL17A and IL17F genes polymorphisms are associated with histopathological changes in transplanted kidney

et al. 2019

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Background Interleukin 17 is a proinflammatory cytokine involved in immune response after allograft transplantation. IL-17 family of proinflammatory cytokines includes IL-17A and IL-17F . Previous studies have demonstrated that the rs2275913 IL17A and the rs11465553 IL17F gene polymorphism are associated with kidney allograft function. Because of the association between these polymorphisms and post-transplant immune response, we assume that these single nucleotide polymorphisms may affect morphological structure of transplanted kidney. The aim of this study was to examine the association of rs2275913 IL17A and rs2397084, rs11465553 and rs763780 IL17F gene polymorphisms with histopathological changes in transplanted kidney biopsies such as: glomerulitis, tubulitis, arteritis, cell infilitration and fibrosis. Methods The study enrolled 82 patients after renal graft transplantation in whom a kidney biopsy was performed because of impaired graft function. The rs2397084 T > C (Glu126Gly), rs11465553 G > A (Val155Ile) and rs763780 T > C (His167Arg) polymorphisms within the IL17F gene and the rs2275913 A > G (− 197 A > G) polymorphism within the IL17A gene promoter were genotyped using TaqMan genotyping assays on a 7500 FAST Real-Time PCR System (Applied Biosystems, USA). Results There was a significant association between the rs2275913 IL17A gene polymorphism and the grade of tubulitis, which was more severe among patients with the A allele, compared to recipients with the GG genotype (GG vs. AG + AA, P = 0.02), and with the grade of arteriolar hyaline thickening and mesangial matrix increase, which were more severe among patients with the G allele compared to recipients with the AA genotype (AA vs. AG + GG, P = 0.01 and P = 0.04, respectively). Tubular atrophy and interstitial fibrosis were more severe among individuals with the C allele at the rs763780 IL17F gene polymorphism (TT vs. TC, P = 0.09 and P = 0.017, respectively). However, it should be taken into account that the statistical significance was achieved without correction for multiple testing, and no significant association would remain significant after such correction. Conclusions The results of this study may suggest a possible association between the rs2275913 IL17A and rs2275913 IL17A gene polymorphisms and some histopathological changes in transplanted kidney biopsies. Electronic supplementary material The online version of this article (10.1186/s12882-019-13...

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Section: Discussionmentioning

confidence: 99%

IL17A and IL17F genes polymorphisms are associated with histopathological changes in transplanted kidney

et al. 2019

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“…The immune system can cause significant problems in terms of the acute and chronic rejection of kidney transplantations [ 103 , 104 ]. These complications have resulted in a constant search for new ways to reduce the likelihood of such outcomes [ 105 , 106 ]. One of the pioneers of immunosuppression is Jean Hamburger, who used total body irradiation to prevent the rejection of transplants.…”

Section: Immunosuppression and Patient Carementioning

confidence: 99%

Novel surgical techniques, regenerative medicine, tissue engineering and innovative immunosuppression in kidney transplantation

Nowacki¹,

Nazarewski²,

Kloskowski³

et al. 2016

aoms

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On the 60th anniversary of the first successfully performed renal transplantation, we summarize the historical, current and potential future status of kidney transplantation. We discuss three different aspects with a potential significant influence on kidney transplantation progress: the development of surgical techniques, the influence of regenerative medicine and tissue engineering, and changes in immunosuppression. We evaluate the standard open surgical procedures with modern techniques and compare them to less invasive videoscopic as well as robotic techniques. The role of tissue engineering and regenerative medicine as a potential method for future kidney regeneration or replacement and the interesting search for novel solutions in the field of immunosuppression will be discussed. After 60 years since the first successfully performed kidney transplantation, we can conclude that the greatest achievements are associated with the development of surgical techniques and with planned systemic immunosuppression.

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“…Glomerulosclerosis, tubular atrophy and interstitial fibrosis (TA/IF) damage the transplanted organ, causing kidney function deterioration. Development of allograft histopathological changes involves both immunological and non-immunological factors (Kłoda et al, 2010;Domański et al, 2013). Early detection of TA/IF allows clinicians to low down or even stop the chronic dysfunction of the transplanted kidney.…”

Section: Introductionmentioning

confidence: 99%

N-acetyl-beta-glucosaminidase urine activity as a marker of early proximal tubule damage and a predictor of the long-term function of the transplanted kidneys.

et al. 2014

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Introduction: Ischaemia-reperfusion injury (IRI) is a factor leading to the damages of the transplanted kidney,what affects mainly the proximal tubules. Early monitoring of tubule damage can be an efficient tool to predict the allograft dysfunction. Present in proximal tubules, N-acetyl-beta-glucosaminidase (NAG) is a lysosomal enzyme whose excretion rises as a result of IRI or acute rejection. The aim of this study was to monitor the NAG urine activity to evaluate the early proximal tubule damage, and to try to predict the long-term function of the transplanted kidney. Material and methods: The study enrolled 87 Caucasian renal transplant recipients (61.7% males, 38.3% females, mean age 45.56±14.34 years). Urine samples were collected for NAG and creatinine analysis on the 1st day after transplantation, and then in the 3rd and 12th month. Protocol biopsies were performed in the 3rd and 12th month. Results: A significant positive correlation between NAG urine activity in the 3rd month after transplantation and creatinine concentration on the 14th (p=0.004) and 30th day (p=0.05), in the 3rd month (p=0.009) and after the 1st (p=0.005) and 2nd year (p=0.003) was observed. A statistically significantly higher urinary NAG activity in samples collected in the first 3 days and in the 3rd month after transplantation among patients with DGF (p=0.006 and p=0.03 respectively) was found. There was a significant positive correlation between NAG urine activity in the 3rd month and the grade of tubular atrophy in specimens collected in the 3rd (p=0.03) and 12th (p=0.04) month. Conclusions: Monitoring of NAG urine activity is useful in the evaluation of early proximal tubule damage and predicting the long-term function of the transplanted kidneys.

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Correlation between ICAM1 and VCAM1 gene polymorphisms and histopathological changes in kidney allograft biopsies

Cited by 12 publications

References 30 publications

IL17A and IL17F genes polymorphisms are associated with histopathological changes in transplanted kidney

IL17A and IL17F genes polymorphisms are associated with histopathological changes in transplanted kidney

Novel surgical techniques, regenerative medicine, tissue engineering and innovative immunosuppression in kidney transplantation

N-acetyl-beta-glucosaminidase urine activity as a marker of early proximal tubule damage and a predictor of the long-term function of the transplanted kidneys.

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