Leukocytapheresis in rheumatoid arthritis

Safety and efficacy of the leukocytapheresis procedure in eighty-five patients with rheumatoid arthritis

“…Improvement was evaluated using the DAS28 and EULAR improvement criteria. We evaluated efficacy until 4 weeks after the completion of treatment, because it had shown that disease activity of responders improved by 4weeks after the completion [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. If their disease activity have gotten worse while observation period, we have to add other medication ethically.…”

“…LCAP does not have severe side effects associated with traditional immunosuppression regimens which make this therapy an effective alternative strategy for RA treatment when conventional DMARDs and immunosuppressants cannot be used. Sporadic reports have suggested the efficacy of LCAP in treating such refractory patients (Table 1) [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”

Granulocyte and monocyte/macrophage apheresis in paediatric patients with ulcerative colitis: a case series in Spain

“… 10 Hence, a non-pharmacological therapy such as GMA has its place in the treatment of UC in children and adolescents. In adult patients, GMA is used in IBD, mainly in UC treatment 36 but also in Crohn’s disease 36 as well as in rheumatoid arthritis, 37 arthropathies and dermatological diseases such as psoriasis. 36 There is a series of clinical scenarios where GMA should be considered ( Box 2 ).…”

Rheumatoid arthritis: Development after the emergence of a chemokine for neutrophils in the synovium

“…Leukocytapheresis with a column of polyethylenephtarate fibers is a method used to capture circulating granulocytes, monocytes, and lymphocytes. [97] This method has been used to treat ulcerative colitis [97,98] or to prevent a graft-versus-host reaction during blood transfusion [99] . Several groups have tested this therapy to dozens of patients with active RA and observed improvement of articular symptoms.…”