Safety and efficacy of the leukocytapheresis procedure in eighty-five patients with rheumatoid arthritis

Kitagaichi, Mie; Kusaoi, Makio; Tsukahara, Takayoshi; Murayama, Go; Nemoto, Takuya; Sekiya, Fumio; Kon, Takayuki; Ogasawara, Michihiro; Kempe, Kazuo; Yamaji, Katsuhiko; Tamura, Naoto; Tsuda, Hiroshi; Takasaki, Yoshinari

doi:10.1016/j.transci.2016.07.019

Cited by 5 publications

(4 citation statements)

References 30 publications

(70 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our cases, the numbers of leukocytes in peripheral circulation decreased after the completion of each LCAP session, yet by the next session, these numbers had recovered. A similar phenomenon has been observed in previous reports [3,6]. Hidaka et al have reported that during the recovery of peripheral leukocytes, activated T lymphocytes, which are well known to play a critical role in RA pathogenesis, are redistributed from the affected joints into the circulating blood.…”

Section: Discussionsupporting

confidence: 87%

“…Previous studies have shown the therapeutic effectiveness and safety of LCAP for the treatment of RA patients who are refractory to multiple csDMARDs [4][5][6]. Although comparable data regarding bDMARD-resistant patients is limited, there are a few published cases, in which high-throughput LCAP restored a reduced response to infliximab in RA patients [7].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Leukocytapheresis for rheumatoid arthritis cases that are super-resistant to any class of biological drugs and tofacitinib

Mori

2020

Transfusion and Apheresis Science

View full text Add to dashboard Cite

Many biological disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs) are currently available as treatment options for rheumatoid arthritis (RA), but a subset of RA patients shows inadequate responses to any of these DMARDs. This phenomenon, which we call super-resistance, is becoming a serious concern. In this study, I present two cases of super-resistant RA in which patients failed to respond to treatment with bDMARDs of any class as well as to tsDMARD therapy with tofacitinib. In these cases, leukocytapheresis (LCAP), a treatment that removes overabundant leukocytes from the body, rapidly induced low disease activity and made patients subsequently responsive to previously ineffective DMARDs. My experience with the present cases suggests that LCAP is worth considering as an alternative therapeutic option for the management of RA patients with super-resistance to DMARD therapies.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Leukocytapheresis for rheumatoid arthritis cases that are super-resistant to any class of biological drugs and tofacitinib

Mori

2020

Transfusion and Apheresis Science

View full text Add to dashboard Cite

show abstract

“…Several groups have tested this therapy to dozens of patients with active RA and observed improvement of articular symptoms. [100][101][102] However, no groups attributed the improvement to the decrease in circulating neutrophils. To decrease circulating neutrophils, anti-IL-17A antibody would also be effective because IL-17A stimulates bone marrow stroma cells to secrete G-CSF.…”

Section: Suppression Of Neutrophil Recruitment May Be a Promising The...mentioning

confidence: 99%

Rheumatoid arthritis: Development after the emergence of a chemokine for neutrophils in the synovium

Katayama¹

2021

BioEssays

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) may not be a multifactorial disease; it can be hypothesized that RA is developed through a series of events following a triggering event, which is the emergence of a chemokine for neutrophils in the synovium. IL‐17A, secreted by infiltrated neutrophils, stimulates synoviocytes to produce CCL20, which attracts various CCR6‐expressing cells, including Th17 cells. Monocytes (macrophages) appear after neutrophil infiltration according to the natural course of inflammation and secrete IL‐1β and TNFα. Then, IL‐17A, IL‐1β, and TNFα stimulate synoviocytes to produce CCL20, amplifying the inflammation. Varieties of chemokines secreted by infiltrating cells accumulate in the synovium and induce synoviocyte proliferation by binding to the corresponding G protein‐coupled receptors, thus expanding the synovial tissue. CCL20 in this tissue attracts circulating monocytes that express both CCR6 and receptor activator of NF‐κB (RANK), which differentiate into osteoclasts in the presence of RANKL. In this way, pannus is formed, and bone destruction begins.

show abstract

“…Rheumatoid arthritis (RA) is a systemic inflammatory disease in which the predominant symptom is polyarthritis characterized by destructive synovitis and various immune disorders [1,2]. Synovial inflammation promotes an immune response that causes articular cartilage degradation leading to joint space narrowing (JSN) [3,4].…”

Section: Introductionmentioning

confidence: 99%

Quantification of Joint Space Width Difference on Radiography Via Phase-Only Correlation (POC) Analysis: a Phantom Study Comparing with Various Tomographical Modalities Using Conventional Margin-Contouring

Taguchi

Shishido

et al. 2020

J Digit Imaging

View full text Add to dashboard Cite

Several visual scoring methods are currently used to assess progression of rheumatoid arthritis (RA) on radiography. However, they are limited by its subjectivity and insufficient sensitivity. We have developed an original measurement system which uses a technique called phase-only correlation (POC). The purpose of this study is to validate the system by using a phantom simulating the joint of RA patients. A micrometer measurement apparatus that can adjust arbitrary joint space width (JSW) in a phantom joint was developed to define true JSW. The phantom was scanned with radiography, 320 multi detector CT (MDCT), high-resolution peripheral quantitative CT (HR-pQCT), cone beam CT (CBCT), and tomosynthesis. The width was adjusted to the average size of a women's metacarpophalangeal joint, from 1.2 to 2.2 mm with increments of 0.1 mm and 0.01 mm. Radiographical images were analyzed by the POC-based system and manual method, and images from various tomographical modalities were measured via the automatic margin detection method. Correlation coefficients between true JSW difference and measured JSW difference were all strong at 0.1 mm intervals with radiography (POC-based system and manual method), CBCT, 320MDCT, HR-pQCT, and tomosynthesis. At 0.01 mm intervals, radiography (POC-based system), 320MDCT, and HR-pQCT had strong correlations, while radiography (manual method) and CBCT had low correlations, and tomosynthesis had no statistically significant correlation. The smallest detectable changes for radiography (POC-based system), radiography (manual method), 320MDCT, HR-pQCT, CBCT, and tomosynthesis were 0.020 mm, 0.041 mm, 0.076 mm, 0.077 mm, 0.057 mm, and 0.087 mm, respectively. We conclude that radiography analyzed with the POC-based system might sensitively detect minute joint space changes of the finger joint.

show abstract

Safety and efficacy of the leukocytapheresis procedure in eighty-five patients with rheumatoid arthritis

Cited by 5 publications

References 30 publications

Leukocytapheresis for rheumatoid arthritis cases that are super-resistant to any class of biological drugs and tofacitinib

Leukocytapheresis for rheumatoid arthritis cases that are super-resistant to any class of biological drugs and tofacitinib

Rheumatoid arthritis: Development after the emergence of a chemokine for neutrophils in the synovium

Quantification of Joint Space Width Difference on Radiography Via Phase-Only Correlation (POC) Analysis: a Phantom Study Comparing with Various Tomographical Modalities Using Conventional Margin-Contouring

Contact Info

Product

Resources

About