Leukoaraiosis with mild cognitive impairment

Mi, Te; Zhao, Ethan; Zheng, Xingyue; Sun, Qinjian; Qu, Chen

doi:10.1179/1743132815y.0000000028

Cited by 18 publications

(13 citation statements)

References 32 publications

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“…Cognitive impairment, the most common clinical feature associated with ILA, manifests as deficits in thinking ability, memory, executive function, and attention ability (Sultzer et al, 1995 ; Li et al, 2017 ). Previous studies have suggested that normal elderly individuals with ILA are at high-risk of further cognitive decline, and the magnitude of the ILA is positively correlated with the severity of cognitive deficits (Ross et al, 2005 ; Te et al, 2015 ; Chen et al, 2016 ). However, the neurobiological pathway underlying cognitive impairment in ILA has not been well illuminated.…”

Section: Introductionmentioning

confidence: 99%

Functional Disorganization of Small-World Brain Networks in Patients With Ischemic Leukoaraiosis

Zhu

Lü

Xie

et al. 2020

Front. Aging Neurosci.

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Cognitive impairment is a key clinical feature of ischemic leukoaraiosis (ILA); however, the underlying neurobiological mechanism is still unclear. ILA has been associated with widespread gray and white matter (WM) damage mainly located in cortical-cortical and cortico-subcortical pathways. A total of 36 patients with ILA (Fazekas rating score ≥2) and 31 healthy controls (HCs) underwent comprehensive neuropsychological assessments (covering four cognitive domains, i.e., information processing speed, episodic memory, executive and visuospatial function) and resting-state functional MRI scans. Graph theory-based analyses were employed to explore the topological organization of the brain connectome in ILA patients, and we further sought to explore the associations of connectome-based metrics and neuropsychological performances. An efficient small-world architecture in the functional brain connectome was observed in the ILA and control groups. Moreover, compared with the HCs, the ILA patients showed increased path length and decreased network efficiency (i.e., global and local efficiency) in their functional brain networks. Further network-based statistic (NBS) analysis revealed a functional-disconnected network in ILA, which is comprised of functional connections linking different brain modules (i.e., default mode, frontoparietal, ventral attention and limbic systems) and connections within single modules (i.e., ventral attention and limbic systems). Intriguingly, the abnormal network metrics correlated with cognitive deficits in ILA patients. Therefore, our findings provide further evidence to support the concept that ILA pathologies could disrupt brain connections, impairing network functioning, and cognition via a "disconnection syndrome."

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Section: Introductionmentioning

confidence: 99%

Functional Disorganization of Small-World Brain Networks in Patients With Ischemic Leukoaraiosis

Zhu

Lü

Xie

et al. 2020

Front. Aging Neurosci.

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“…It refers to specked or patchy change in the periventricular or subcortical white matter of multiple causes. Studies have shown that LA patients have evident cognitive impairment, [1,2] but the underlying neural mechanism remains still unclear and might be associated with the damage to the prefrontal-striatal pathway. [3,4] In recent years, diffusion tensor imaging (DTI), a new functional magnetic resonance imaging, is developed for the quantification of the diffusion of water in tissues, and then the fractional anisotropy (FA) of water in tissues is used to infer the ultrastructure characteristics and pathological changes.…”

Section: Introductionmentioning

confidence: 99%

Correlation between prefrontal-striatal pathway impairment and cognitive impairment in patients with leukoaraiosis

Wang¹,

Yuan

Guo³

et al. 2017

Medicine

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Our study aimed to investigate the changes of white matter microstructure of cortico-subcortical pathways using diffusion tensor imaging (DTI), and to explore the relationship between abnormal parameters of DTI and cognitive function underlying in patients with leukoaraiosis (LA).A total of 42 patients with LA and 42 age- and sex-matched healthy controls were recruited from Beijing Chaoyang Hospital, Capital Medical University between January 2012 and December 2012. All the subjects underwent scans of conventional magnetic resonance imaging and DTI, and a comprehensive neuropsychological battery was utilized. The regions of interest (ROIs) were located at the white matter of centrum semiovale, anterior and posterior periventricular white matter, basal ganglia, corpus callosum. The averaged values of mean diffusivity (MD) and fractional anisotropy (FA) were quantified both within white matter lesions (WMLs) and normal appearing white matter (NAWM). A linear regression analysis was performed to assess the association between diffusion parameters and decline in cognitive domains.Patients with LA were associated with comprehensive cognitive function deficits. We found that significantly decreased FA and increased MD in WMLs at the 5 ROIs than that of NAWM and controls (P < .05). The values of FA in NAWM were significantly lower and MD in NAWM were significantly higher at centrum semiovale and posterior periventricular white matter than that of controls (P < .05). The values of FA in WMLs at anterior periventricular white matter were positively related to the performances of cognition in patients with LA (P < .05). The values of FA in NAWM located at anterior periventricular white matter were positively related to the score of Digit-symbol test (r = 0.446, P = .002). The values of FA in NAWM located at anterior periventricular white matter correlated inversely with the Z scores of executive function (r = −0.418, P = .03).In our study, patients with LA exhibited significant cognitive impairment especially in the domains of executive function. The technique of DTI revealed that the reduced FA and increased MD at the corresponding regions of cortico-subcortical pathways in patients with LA. DTI may be of great help for an early pathology of white matter microstructure underlying in patients with LA.

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“…Our study found that MoCA, immediate word recall and delayed word recall were influenced by the WML severity in the hypertension group and mixed factor group, and MoCA and immediate word recall in the hypertension group and mixed factor group were statistically different than in no risk factor group, suggesting that WML had comprehensive effects on cognition. Te et al 23 believed that WML patients with MCI obviously presented the declining of memory and attention, damage of executive function and close connection with dementia in the early days. Zi et al 24 found out that a cognitive test for patients with periventricular high signal lesion shows obvious declining of word fluency and executive function.…”

Section: Effect Of Risk Factors On Severity Of Wmlmentioning

confidence: 99%

Cognitive features of white matter lesions accompanied by different risk factors of cerebrovascular diseases

et al. 2019

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Background. The relationship between different risk factors and the cognitive impairment of white matter lesions (WML) remains poorly understood. Objectives. To investigate the features of cognitive impairment of patients diagnosed with WML accompanied by different risk factors of cerebrovascular diseases. Material and methods. A total of 157 cases of WML patients were divided into no risk factor group (n = 26), hypertension group (n = 35), diabetes mellitus group (n = 27), dyslipidemia group (n = 30), and mixed factors group (n = 39). Results. The severity of WML (Fazekas score) in the hypertension and mixed factors groups was higher than in the non-risk factors group. The Montreal Cognitive Assessment (MoCA) scores in the hypertension and mixed factors groups were lower than in the non-risk factors group. The scores of MoCA, immediate memory and delayed recall in the hypertension and mixed factors groups with Fazekas score ≥3 were lower than in the peer group with Fazekas score <3. The scores of MoCA and immediate memory in the hypertension and mixed factors groups with Fazekas score ≥3 were lower than in the non-risk factors group with Fazekas score ≥3. Conclusions. Hypertension aggravates the severity of WML and cognitive impairment. The severity of WML is positively correlated with the severity of cognitive impairment accompanied by these risk factors.

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Leukoaraiosis with mild cognitive impairment

Cited by 18 publications

References 32 publications

Functional Disorganization of Small-World Brain Networks in Patients With Ischemic Leukoaraiosis

Functional Disorganization of Small-World Brain Networks in Patients With Ischemic Leukoaraiosis

Correlation between prefrontal-striatal pathway impairment and cognitive impairment in patients with leukoaraiosis

Cognitive features of white matter lesions accompanied by different risk factors of cerebrovascular diseases

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