Leukemic reticuloendotheliosis. A clinicopathologic study with review of the literature

Katayama, Isao; Finkel, Harvey E.

doi:10.1016/0002-9343(74)90776-1

Cited by 161 publications

(43 citation statements)

References 44 publications

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“…28,29 We, therefore, speculate that TIA-1 expression may account for the presence of azurophilic granules in hairy cells. TIA-1 is also expressed in granulocytes, 6,7 in addition to cytotoxic T cells and NK cells.…”

Section: Discussionmentioning

confidence: 88%

“…Hairy cell leukemia, formerly known as leukemic reticuloendotheliosis, [25][26][27][28][29][30][31] is characterized by bone marrow 32 and splenic involvement by small to medium-sized neoplastic cells with abundant cytoplasm and hairy projections. [33][34][35] In our present study, hairy cytoplasmic projections were observed in the peripheral blood in most cases (7/9) by electron or phase-contrast microscopy.…”

Section: Discussionmentioning

confidence: 99%

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TIA-1 expression in hairy cell leukemia

et al. 2004

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We measured T-cell intracellular antigen-1 (TIA-1) expression in neoplastic cells from patients with hairy cell leukemia. Five of nine cases were positive for cytoplasmic TIA-1, with a small, dot-like, granular expression pattern. However, neoplastic cells were granzyme B-and perforin-negative in all cases. Other positive markers were CD20 in 9/9 cases, CD19 in 9/9 cases, DBA44 in 8/9 cases, LeuM5(CD11C) in 8/9 cases, IL-2R(CD25) in 7/9 cases, CD103 in 7/9 cases, FMC7 in 6/9 cases, and tartrate-resistant acid phosphatase in 5/7 cases. We also analyzed TIA-1 expression in 94 B cell lymphomas, including 19 diffuse, large cell lymphomas, 19 mantle cell lymphomas, six follicular lymphomas, two extranodal marginal zone B-cell lymphomas, 13 nodal marginal zone B-cell lymphomas, one mediastinal large-cell lymphoma, 19 diffuse small-cell lymphomas, 14 myelomas, and one splenic lymphoma with villous lymphocytes. All cases were negative for TIA-1 expression. Based on these findings, TIA-1 expression in neoplastic cells of low-grade B-cell lymphomas may be a good diagnostic marker for hairy cell leukemia. Moreover, TIA-1 reactivity in lymphomas does not necessarily indicate a T-or NK-cell derivation.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

TIA-1 expression in hairy cell leukemia

et al. 2004

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“…Since the precise clinical onset of the hernia was not known, we could not determine whether one or a combination of these factors acted in our patient. We could only find one report [7] that described hairy cell leukemia present ing with an inguinal hernia, but there was no mention of the hernial-sac histology. Considering the fre quency of splenomegaly in hairy cell leukemia, it is surprising that more patients have not been reported with abdominal-wall hernias.…”

Section: Discussionmentioning

confidence: 99%

Hairy Cell Leukemia Involving an Inguinal Hernial Sac

Melaragno

Theil²,

Marsh³

et al. 1990

Acta Haematol

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A 37-year-old man with hairy cell leukemia was found incidentally to have a right inguinal hernia. Microscopic examination of the resected herniorrhaphy specimen disclosed dense transmural infiltration by hairy cells. Electron-microscopic and immunoperoxidase studies confirmed the presence of surface cytoplasmic projections and B cell phenotype, respectively, of the infiltrating cells. This case is, to our knowledge, the first reported instance of hairy cell leukemia involving a hernial sac and demonstrates the capacity of hairy cells to infiltrate unexpected soft-tissue sites.

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“…Patients with HCL are usually males who show marked splenomegaly associat ed with pancytopenia and minimal lymphadenopathy [1][2][3][4][5]. Peripheral blood smears show varying numbers of hairy mononuclear cells which contain TRAP, show B-cell surface markers and are cap able of some degree of phagocytosis [2,3].…”

Section: Discussionmentioning

confidence: 99%

“…Hairy cell leukemia (HCL) is a rare dis ease with an insidious clinical course char acterized by pancytopenia, marked splen omegaly and minimal lymphadenopathy [1][2][3][4][5]. Rare cases present with marked lym phadenopathy associated with a mediasti nal mass and may mimic malignant lym phoma [2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Hairy Cell Leukemia: Report of an Unusual Case with Hepatomegaly due to a Large Vascular Tumor of the Liver, Mediastinal Mass and Pleural Effusion Containing Hairy Cells

Raz

Okon

et al. 1984

Acta Haematol

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An unusual patient with hairy cell leukemia (HCL) who developed marked hepatomegaly due to a large vascular tumor in the liver is reported. The relation of this vascular tumor to the microscopic splenic pseudosinuses and hepatic angiomatous lesions encountered in HCL is discussed. To the best of our knowledge this represents the first case report of the association of HCL with large macroscopic hemangioma of the liver causing hepatomegaly. The patient also developed a large paratracheal mediastinal mass with a recurrent pleural effusion which was shown to contain many typical hairy cells. This rare finding is discussed in relation to the isolated cases of lymphocytic lymphoma who present with clinical and morphological features mimicking HCL. This patient had HCL according to all established criteria with characteristic morphological, cytochemical and ultrastructural features and the pleural effusion and mediastinal mass were most probably part of the HCL neoplasia, despite the fact that biopsy was not performed.

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Leukemic reticuloendotheliosis. A clinicopathologic study with review of the literature

Cited by 161 publications

References 44 publications

TIA-1 expression in hairy cell leukemia

TIA-1 expression in hairy cell leukemia

Hairy Cell Leukemia Involving an Inguinal Hernial Sac

Hairy Cell Leukemia: Report of an Unusual Case with Hepatomegaly due to a Large Vascular Tumor of the Liver, Mediastinal Mass and Pleural Effusion Containing Hairy Cells

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