Hairy Cell Leukemia Involving an Inguinal Hernial Sac

Abstract

A 37-year-old man with hairy cell leukemia was found incidentally to have a right inguinal hernia. Microscopic examination of the resected herniorrhaphy specimen disclosed dense transmural infiltration by hairy cells. Electron-microscopic and immunoperoxidase studies confirmed the presence of surface cytoplasmic projections and B cell phenotype, respectively, of the infiltrating cells. This case is, to our knowledge, the first reported instance of hairy cell leukemia involving a hernial sac and demonstrates the capacity of hairy cells to infiltrate unexpected soft-tissue sites.

Treatment options in skeletal localizations of hairy cell leukemia: A systematic review on the role of radiation therapy

“…One of the most prominent clinical features is immunodepression with an increased risk of developing infections, involving mainly lung, urinary tract, liver, and CNS. Unusual complications are represented by intrathoracic and intra-abdominal lymphadenopathy [8], cutaneous involvement [9][10][11], pleural and peritoneal involvement [12], ocular [13], meningeal [14], renal [15], hernial sac localizations [16], amyloidosis [17], and paraproteinemias [3,[18][19][20].…”

Specific skin lesions in hairy cell leukemia at presentation: case report and review of literature

“…It may be found in a variety of leukemia's. Clinical aspects of specific lesions in HCL show wide polymorphism such as maculopapular eruptions, nodules, infiltrative plaques and ulcers [5][6][7][8]. The biopsy indicates that cell infiltrates are perivascular involving the dermis and sparing epidermis [3].…”