Treatment options in skeletal localizations of hairy cell leukemia: A systematic review on the role of radiation therapy

Abstract

Skeletal localizations are a rare complication in hairy cell leukaemia patients, with an extimated incidence of 3%. These lesions, mainly osteolytic, can occur at various sites and are almost always symptomatic. Localized radiation therapy (RT) has been extensively used as effective palliative treatment in such cases, with different total doses and fractionation schedules. In this article, a systematic review of all reported cases with osseous complications is presented, to underline the role of RT and to define the most appropriate approach in this subset of patients. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.

Hairy Cell Leukemia Presenting with Isolated Bone Lesions

“…Saçlı hücreli löseminin bu şekide izole kemik tutulumu çok nadirdir. Literatürde bu durumda sadece birkaç olgu bildirilmiştir (4,(7)(8)(9). Bu açıdan bakıldığında sunduğu-muz olgu literatüre katkı sunmaktadır.…”

“…Saçlı hücreli löse-mi hastalarında splenomegali ve pansitopeni sık rastlanan bulgulardır (2,3). Saçlı hücreli löseminin izole litik kemik lezyonu tutulumu şeklinde klinik bulgularla karakterli olguları çok nadir olup literatürde sadece olgu sunumları şeklinde bildirilmiştir (4). Bu hastalığın gelişimindeki rolü yeni tanımlanmış bir mutasyon olan BRAF mutasyonu saç-lı hücreli lösemi tanısının konulmasında kullanılabilecek yeni belirteçler arasında yer almaktadır (5).…”

Hairy Cell Leukemia and Bone Pain

“…Lytic bone lesions are considered a rare and unusual finding in cases of hairy cell leukemia, particularly at the time of presentation, but may be present in about 3% of all patients (Pemmaraju et al, 2015). The most prominent site of skeletal involvement tends to be the proximal femur neck or head, but other less common bony sites include the skull, ribs, humerus, vertebrae, tibia, and fibulae (Filippi, Franco, Marinone, Tarella, & Ricardi, 2007). In a systematic review of cases, the most common presenting symptom of bony involvement was localized pain, which is an uncommon symptom of hairy cell leukemia (Filippi et al, 2007).…”

Isolated sacral injury in hairy cell leukemia: A case report and analysis of literature data

“…В связи с появлением эффективных медикаментозных средств лечения ВКЛ в настоящее время общепризнано, что ле-чение костного поражения должно быть не столько локальным (резекция, протезирование, лучевая терапия), сколько систем-ным (интерферон α, аналогам пурина) [8,11,24].…”