Leukemic–lymphomatous infiltration of skeletal muscle:Systematic study of 82 autopsy cases

Abstract

A systematic investigation of neoplastic infiltration in skeletal muscle was performed utilizing up to 12 selected muscle samples in 82 autopsies of patients with leukemia or lymphoma. Tumor foci were recorded in one or more muscles in 43 of these 82 cases. The most extensive involvement was found in monocytic leukemia, where 36% (48 out of 132 muscle samples taken) were infiltrated. There was general correlation between muscular involvement, degree of visceral infiltration, and, in leukemia, also the number of circulating leukemic cells. Secondary changes in skeletal muscle occurring independently of leukemic‐lymphomatous infiltration or compromise of neurovascular supply are alluded to. The study showed that, contrary to common assumption and scant literature reports, skeletal muscle involvement in leukemia‐lymphoma is not a rare phenomenon.

Lymphoma of bone, muscle, and skin: CT findings.

“…In an autopsy study of 82 cases of lymphoma, Buerger and Monteleone [3] found histologic evidence of lymphomatous muscle infiltration but no gross enlargement of muscles. The site of lymphomatous infiltration of muscle may be the primary site (Fig.…”

Primary non-Hodgkin's lymphoma in the dorsolumbar muscles

“…On admission, chest roentgenography did not show any abnormalities in the lung fields. 9 However, the tumor (20 ϫ 16 cm) in our patient's back was too large to consider it a secondary lesion, and various examinations did not show any other tumors, except for those in the lung and the back skeletal muscles. 1).…”

Metachronous second primary malignant fibrous histiocytoma in two skeletal muscles

“…The spindled cells have G1 mean DNA values within 2 SD of control cell values (near-diploid DNA content). [33,34,38,39], kidney [40][41][42], prostate [43], stomach [44], lung [35], lymphoma [45], lip [46], breast [47], and pancreas [48]. In animals, adenocarcinoma of the lung in cats [49], thyroid tumors in rats [50], and malignant schwannoma of rats [5 11 have been shown to metastasize spontaneously to skeletal muscle.…”