Leukemia-Like Cancer in Bivalves

Odintsova, N. A.

doi:10.1134/s1063074020020078

Cited by 13 publications

(10 citation statements)

References 88 publications

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“…variable in shape) and larger than that of normal hemocytes. As the disease progresses, the proliferating cells infiltrate other tissues, which leads to the loss of integration and normal functioning of organs 24 , 25 . DN may reach an epizootic level, causing mass mortality in wild and commercial bivalve populations 14 , 22 , 24 .…”

Section: Introductionmentioning

confidence: 99%

First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself

Skazina

Odintsova

Maiorova

et al. 2021

Sci Rep

130

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Two lineages of bivalve transmissible neoplasia (BTN), BTN1 and BTN2, are known in blue mussels Mytilus. Both lineages derive from the Pacific mussel M. trossulus and are identified primarily by their unique genotypes of the nuclear gene EF1α. BTN1 is found in populations of M. trossulus from the Northeast Pacific, while BTN2 has been detected in populations of other Mytilus species worldwide but not in M. trossulus itself. Here we examined M. trossulus from the Sea of Japan (Northwest Pacific) for the presence of BTN. Using hemocytology and flow cytometry of the hemolymph, we confirmed the presence of disseminated neoplasia in our specimens. Cancerous mussels possessed the BTN2 EF1α genotype and two mitochondrial haplotypes with different recombinant control regions, similar to that of common BTN2 lineages. This is the first report of BTN2 in its original host species M. trossulus. A comparison of all available BTN and M. trossulus COI sequences suggests a common and recent origin of BTN2 diversity in populations of M. trossulus outside the Northeast Pacific, possibly in the Northwest Pacific.

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Section: Introductionmentioning

confidence: 99%

First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself

Skazina

Odintsova

Maiorova

et al. 2021

Sci Rep

130

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“…NCs, most likely of haemocyte origin, are characterized by high aneuploidy level, higher nucleus-cytoplasm volume ratio and increased proliferative activity resulting in nuclear and cellular hypertrophy (Thriot-Quiévreux & Wo lowicz 1996, Smolarz et al 2005ac, Smolarz et al 2006a, Carella et al 2013, Carella et al 2017). Yet, alteration level in specific physiological and biochemical parameters of NCs differ between species (Barber et al 2004, Le Grand et al 2014, Carballal et al 2015, Odintsova 2020. During cancer progression NCs are able to disseminate into tissues of an organism, leading to histological modifications, tissue/organ malfunction and eventually to death of an animal (Barber 2004, Carella et al 2015, Carballal et al 2015.…”

Section: Introductionmentioning

confidence: 99%

Horizontal transmission of disseminated neoplasia in the widespread clam Limecola balthica from the Southern Baltic Sea

Michnowska

Hart

Smolarz

et al. 2022

Preprint

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Disseminated neoplasia (DN) is one of the most challenging and unrecognised diseases occurring in aquatic fauna. It has been diagnosed in four bivalve species from the Gulf of Gdańsk (Southern Baltic Sea) with the highest frequency in Limecola balthica (formerly Macoma balthica), reaching up to 94% in some populations. The aetiology of DN in the Baltic Sea has not yet been identified, with earlier studies trying to link its occurrence with environmental pollution. Taking into account recent research providing evidence that DN is horizontally transmitted as clonal cells between individuals in some bivalve species, we aimed to test whether DN is a transmissible cancer in the population of L. balthica from the Gulf of Gdańsk highly affected with cancer. We examined mitochondrial cytochrome c oxidase I (mtCOI) and elongation factor 1α (EF1α) sequences of genomes obtained from haemolymph and tissues of neoplastic and healthy individuals. Sequence analysis resulted in detection of an independent transmissible cancer lineage occurring in 4 neoplastic clams that is not present in healthy animals. This paper describes the first case of transmissible DN in the clam L. balthica providing further insights for studies on this disease.

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“…NCs, most likely of haemocyte origin, are characterized by high aneuploidy level, higher nucleus‐cytoplasm volume ratio and increased proliferative activity resulting in nuclear and cellular hypertrophy (Carella et al, 2013, 2017; Smolarz et al, 2005b,c, 2006; Thriot‐Quiévreux & Wołowicz, 1996). Yet, alteration level in specific physiological and biochemical parameters of NCs differ between species (Barber, 2004; Carballal et al, 2015; Le Grand et al, 2014; Odintsova, 2020). During cancer progression NCs are able to disseminate into tissues of an organism, leading to histological modifications, tissue/organ malfunction and eventually to death of an animal (Barber, 2004; Carballal et al, 2015; Carella et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Horizontal transmission of disseminated neoplasia in the widespread clam Macoma balthica from the Southern Baltic Sea

et al. 2022

View full text Add to dashboard Cite

Disseminated neoplasia (DN) is one of the most challenging and unrecognised diseases occurring in aquatic fauna. It has been diagnosed in four bivalve species from the Gulf of Gdańsk (Southern Baltic Sea) with the highest frequency in Macoma balthica (formerly Limecola balthica), reaching up to 94% in some populations. The aetiology of DN in the Baltic Sea has not yet been identified, with earlier studies trying to link its occurrence with environmental pollution. Taking into account recent research providing evidence that DN is horizontally transmitted as clonal cells between individuals in some bivalve species, we aimed to test whether DN is a bivalve transmissible neoplasia (BTN) in the population of M. balthica from the Gulf of Gdańsk highly affected with cancer. We examined mitochondrial cytochrome c oxidase I (mtCOI) and elongation factor 1α (EF1α) sequences of genomes obtained from haemolymph and tissues of neoplastic and healthy individuals. Sequence analysis resulted in detection of an independent transmissible cancer lineage occurring in four neoplastic clams that is not present in healthy animals. This study describes the first case of BTN in the clam M. balthica (MbaBTN), providing further insights for studies on this disease.

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Leukemia-Like Cancer in Bivalves

Cited by 13 publications

References 88 publications

First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself

First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself

Horizontal transmission of disseminated neoplasia in the widespread clam Limecola balthica from the Southern Baltic Sea

Horizontal transmission of disseminated neoplasia in the widespread clam Macoma balthica from the Southern Baltic Sea

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