Leukemia

Tanaka, Nobuyuki; Matsumoto, Tsuneo; Furukawa, Matakazu; Tokuda, Osamu

doi:10.1007/978-3-642-18832-9_19

Cited by 3 publications

(6 citation statements)

References 44 publications

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“…Nodules with a perilymphatic distribution correspond to infiltration of malignant cells or inflammatory cells or the presence of granulomatous lesions along or adjacent to the lymphatic channel within the lung, which sometimes creates nodular lesions and could be evident in lymphangitic carcinomatosis, leukemic or lymphoma infiltration, lymphocytic interstitial pneumonia, amyloidosis, and sarcoidosis. In leukemic or lymphoma infiltration, this finding and BVB thickening are frequently observed [ 13 , 14 , 28 ]. In infectious diseases, nodules without a perilymphatic distribution, namely, nodules with a centrilobular or random distribution, are frequently observed, with a centrilobular distribution often observed in bacterial pneumonia, fungal infection, CMV pneumonia, and tuberculosis, and with a random distribution often observed in CMV pneumonia and miliary tuberculosis [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Differential diagnosis of infectious diseases, drug-induced lung injury, and pulmonary infiltration due to underlying malignancy in patients with hematological malignancy using HRCT

et al. 2022

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Purpose To differentiate among infectious diseases, drug-induced lung injury (DILI) and pulmonary infiltration due to underlying malignancy (PIUM) based on high-resolution computed tomographic (HRCT) findings from patients with hematological malignancies who underwent chemotherapy or hematopoietic stem cell transplantation. Materials and methods A total of 221 immunocompromised patients with hematological malignancies who had proven chest complications (141 patients with infectious diseases, 24 with DILI and 56 with PIUM) were included. Two chest radiologists evaluated the HRCT findings, including ground-glass opacity, consolidation, nodules, and thickening of bronchovascular bundles (BVBs) and interlobular septa (ILS). After comparing these CT findings among the three groups using the χ2test, multiple logistic regression analyses (infectious vs noninfectious diseases, DILI vs non-DILI, and PIUM vs non-PIUM) were performed to detect useful indicators for differentiation. Results Significant differences were detected in many HRCT findings by the χ2 test. The results from the multiple logistic regression analyses identified several indicators: nodules without a perilymphatic distribution [p = 0.012, odds ratio (95% confidence interval): 4.464 (1.355–11.904)], nodules with a tree-in-bud pattern [p = 0.011, 8.364 (1.637–42.741)], and the absence of ILS thickening[p = 0.003, 3.621 (1.565–8.381)] for infectious diseases, the presence of ILS thickening [p = 0.001, 7.166 (2.343–21.915)] for DILI, and nodules with a perilymphatic distribution [p = 0.011, 4.256 (1.397–12.961)] and lymph node enlargement (p = 0.008, 3.420 (1.385–8.441)] for PIUM. Conclusion ILS thickening, nodules with a perilymphatic distribution, tree-in-bud pattern, and lymph node enlargement could be useful indicators for differentiating among infectious diseases, DILI, and PIUM in patients with hematological malignancies.

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Section: Discussionmentioning

confidence: 99%

Differential diagnosis of infectious diseases, drug-induced lung injury, and pulmonary infiltration due to underlying malignancy in patients with hematological malignancy using HRCT

et al. 2022

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“…7 Several studies have reported that acute leukemia patients presenting with musculoskeletal pain did not tend to show any abnormality in blood cell counts compared to patients without that symptom (28%-67% vs 20%-33%). [3][4][5][6][7][8][9]13,16 It has also been reported that bone pain preceded blood cell abnormalities in leukemic patients. 9,16 In our cases, five of the 10 patients with later confirmed leukemia showed no remarkable abnormalities in blood tests, which means that PXR findings were the only positive test results for leukemia in these five cases.…”

Section: Discussionmentioning

confidence: 97%

“…Radiological evidence of skeletal involvement in leukemia is more frequent in children than in adults 7 . In acute adult leukemia, lucent metaphyseal bands are less common than diffuse osteopenia and osteolytic lesions caused by bone destruction 7 . Several studies have reported that acute leukemia patients presenting with musculoskeletal pain did not tend to show any abnormality in blood cell counts compared to patients without that symptom (28%–67% vs 20%–33%) 3–9,13,16 .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Characteristic findings of plain X‐ray radiography (PXR) in patients with leukemia sometimes contribute to obtaining a proper diagnosis by allowing the patients to proceed to definitive diagnostic procedures 7 . Previous PXR studies in childhood leukemia have reported that abnormalities were found in 7.7%–40% of children with leukemia 3,8,9 .…”

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Utility of emergent plain X‐ray for childhood acute leukemia with bone pain

Ito

Osumi

Fujimori

et al. 2022

Pediatrics International

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Background: We aimed to evaluate the utility of plain X-ray radiograph (PXR) findings in suggesting a diagnosis of acute leukemia in children presenting with bone pain in the emergency department (ED) of a children's hospital. Methods: Using our radiology reporting system and registered data for childhood acute leukemia, we collected data regarding patients who underwent musculoskeletal PXR examinations in the ED due to bone pain in their extremities, from March 1, 2002 to June 30, 2015. We retrospectively reviewed their PXR findings and clinical information from the electronic medical records. Results: A total of 1,331 patients underwent PXR examinations and in 12 PXR findings showed suspected acute leukemia. From the registered data we found 12 acute leukemia patients who underwent emergency extremity PXR. Ten patients were finally confirmed to have acute leukemia by bone marrow examinations. The most common finding was lucent metaphyseal bands, demonstrated in seven cases, whereas six patients did not show any abnormalities in their peripheral blood cell counts. Sensitivity and specificity values of PXR for acute leukemia diagnosis were 90.0% and 99.8%, respectively. Positive predictive value and negative predictive values were 75.0% and 99.9%, respectively. Conclusions: Plain X-ray radiograph is a useful diagnostic tool to detect possible acute leukemia in patients presenting with bone pain, earlier than abnormalities of their peripheral blood cell counts. Our results implied the possibility of re-examining PXRs in acute leukemia more carefully, even when there are no abnormalities in blood cell counts.

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Lymphoproliferative Neoplasms

Ooi¹,

Guermazi²

2006

Medical Radiology

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Leukemia

Cited by 3 publications

References 44 publications

Differential diagnosis of infectious diseases, drug-induced lung injury, and pulmonary infiltration due to underlying malignancy in patients with hematological malignancy using HRCT

Differential diagnosis of infectious diseases, drug-induced lung injury, and pulmonary infiltration due to underlying malignancy in patients with hematological malignancy using HRCT

Utility of emergent plain X‐ray for childhood acute leukemia with bone pain

Lymphoproliferative Neoplasms

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