Leukaemia cutis – Epidemiologie, Klinik und Differenzialdiagnosen

Wagner, Gunnar; Fenchel, Klaus; Back, Walter; Schulz, Alina; Sachse, Michael Max

doi:10.1111/j.1610-0387.2011.07842_suppl.x

Cited by 10 publications

(15 citation statements)

References 30 publications

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“…8 LC usually occurs concomitantly with or following bone marrow disease and may be the presenting sign of relapse of leukemia after chemotherapy. 4,14 Standard induction chemotherapy is less effective in AML patients with skin involvement and requires bone marrow, skin and extramedullary involvementdirected therapy. 13…”

Section: Discussionmentioning

confidence: 99%

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Leukemia Cutis in a 32-Year-Old Male with Acute Myeloid Leukemia

Afsun¹,

Uddin²,

Baker³

et al. 2019

J Enam Med Col

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Leukemia cutis (LC) is a rare cutaneous manifestation of leukemia. Clinical presentation of the disease differs among patients depending on types. LC can precede, follow, occur simultaneously with, or present in the absence of the systemic leukemia. Leukemic involvement of the skin may appear as initial manifestation of recurrence or dissemination of systemic disease. Here we report a case of a 32-year-old male patient known to have acute myeloid leukemia with multiple cutaneous lesions diagnosed as LC. J Enam Med Col 2019; 9(2): 133-135

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Section: Discussionmentioning

confidence: 99%

“…Lesions of LC may be localized or disseminated and can occur on any site of the skin. 4 In most cases, the presence of systemic disease precedes the appearance of skin lesions. 5 Rarely, cutaneous expression of the disease can occur before the evidence of leukemia in peripheral blood and bone marrow making it difficult to diagnose.…”

Section: Introductionmentioning

confidence: 99%

Leukemia Cutis in a 32-Year-Old Male with Acute Myeloid Leukemia

Afsun¹,

Uddin²,

Baker³

et al. 2019

J Enam Med Col

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“…5 Most cases of LC emerge after haematological diagnosis (55 to 77%), 30% at the same time, and less than 10% before haematological diagnosis, in some cases preceding the diagnosis of leukaemia in several months to years. 6,16 Cutaneous involvement usually occurs in the setting of bone marrow, internal organ and peripheral blood involvement, portending a poor outcome. Therefore, it is of paramount importance to screen all patients with specific cutaneous lesions of leukaemia to exclude simultaneous internal organ disease.…”

Section: Leukaemiamentioning

confidence: 99%

“…Some authors defend that generalised distribution of cutaneous lesions may indicate an acute form of leukaemia. 6 Involvement by chronic myeloid leukaemia (CML) is infrequent and may be a harbinger of blastic phase transformation. 6 Chronic lymphoid leukaemia (CLL) is the most frequent type of leukaemia in western countries and may cause cutaneous infiltration in about 4 to 20% of all cases.…”

Section: Leukaemiamentioning

confidence: 99%

“…[4][5][6] Leukaemia cutis (LC) is the term used for cutaneous infiltration by neoplastic leucocytes, and it is probably the best described nosological group in the literature. 6 Regarding lymphomas, attention has been directed mainly to investigating the incidences and relative frequency of primary cutaneous lymphomas (PCL). Most of the publications on secondary cutaneous lymphoma (SCL) are single cases.…”

Section: Introductionmentioning

confidence: 99%

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Specific cutaneous infiltrates in patients with haematological neoplasms: a retrospective study with 49 patients

et al. 2021

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Background: Haematological neoplasms account for around 9% of all cancers, and they are recognised as an important cause of skin infiltration. However, studies analysing cutaneous metastasis of haematological neoplasms are scarce. We describe the clinical spectrum and outcomes of specific cutaneous manifestations of leukaemias, lymphomas, multiple myeloma (MM), and blastic plasmacytoid dendritic cell neoplasm (BPDN) and make a review of the literature.Methods: Data from 49 patients diagnosed with secondary cutaneous infiltration of systemic haematological neoplasms over the last 10 years in a tertiary dermatology centre were retrospectively collected, and clinical-evolutive features were analysed.Results: Most cases were lymphoma (44.9%, n = 22), followed by leukaemia cutis (38.8%, n = 19), secondary plasmacytoma (10.2%, n = 5) and BPDN (6.1%, n = 3). Nodules were the predominant type of lesion, and most patients presented with multiple (≥3) lesions. In 51% (n = 25) of cases, cutaneous infiltration was detected before the diagnosis of the underlying malignancy. The patients in diverse nosological groups did not differ in terms of survival (P = 0.052). Conclusions:We recognise the clinical heterogeneity of specific cutaneous infiltrates. The high proportion of cases in which skin involvement was key to the diagnosis of systemic malignancy emphasises the role of the dermatologist in recognising and correctly managing these patients.

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The Skin and Disorders of the Haematopoietic and Immune Systems

Gniadecki

2016

Rook's Textbook of Dermatology, Ninth Edition

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This chapter reviews skin diseases and symptoms that develop secondarily to underlying malignant or benign diseases of the haematopoietic system. Skin lesions may be caused directly by infiltration of the skin with malignant cells (leukaemia cutis and lymphomatous infiltrates) or by paraproteins secreted by malignant plasma cells (amyloid light‐chain amyloidosis, type I cryoglobulinaemia and macroglobulinaemia cutis). A number of skin signs are an indirect effect of the underlying malignancy, such as paraneoplastic conditions or dermatological syndromes associated with haematological neoplasms (Schnitzler syndrome, POEMS, AESOP and TEMPI syndromes, neurofibromatosis, juvenile xanthogranuloma and juvenile myeloid leukaemia). Kikuchi–Fujimoto disease, Kimura disease, Rosai–Dorfman disease and IgG4‐related disease are idiopathic lymphoadenopathies presenting with characteristic skin lesions. Skin infections, eczematous lesions and vasculitis are the most common cutaneous signs of an underlying immunodeficiency. Chronic skin ulcers may accompany different haemoglobinopathies, such as thalassaemias and sickle cell anaemia. Finally, the skin signs of transfusion reactions (acute allergic reactions, transfusion‐associated graft‐versus‐host disease and post‐transfusion purpura) are reviewed. Diseases of the haematopoietic system often manifest themselves in the skin, and some manifestations are so typical that the dermatologist may be the first physician to detect the underlying blood disorder. More commonly, however, skin symptoms arise in the context of a known haematopoietic disease.

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Leukaemia cutis – Epidemiologie, Klinik und Differenzialdiagnosen

Cited by 10 publications

References 30 publications

Leukemia Cutis in a 32-Year-Old Male with Acute Myeloid Leukemia

Leukemia Cutis in a 32-Year-Old Male with Acute Myeloid Leukemia

Specific cutaneous infiltrates in patients with haematological neoplasms: a retrospective study with 49 patients

The Skin and Disorders of the Haematopoietic and Immune Systems

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