Leucocytes' Parameters for Prediction of the Complications of Acute Corrosive Toxicity

Abstract

Acute corrosive toxicity is a serious problem in clinical toxicology as it may be associated with severe complications. Prediction of complications related to corrosive toxicity is very important for better management and outcome. Inflammation is considered a predisposing factor for the development of corrosive toxicity complications. Leucocytes are a component of the inflammatory process. The aim of this study is to evaluate leucocytes' parameters as predictors for complications of acute corrosive toxicity. Forty four patients with acute corrosive toxicity were subjected to history taking (personal and toxicological), general and local oral examination. A venous blood sample was obtained from each participant. Total and differential leucocyte counts together with neutrophil-to-lymphocyte ratio were obtained. Total leucocyte count, neutrophil count and neutrophil-tolymphocyte ratio were good predictors for complications at cut off > 15100/mm 3 , > 9308/mm 3 and > 2.42 respectively. It is concluded that total leucocyte count, neutrophil count and neutrophil-to-lymphocyte ratio could serve as good predictor markers for corrosive toxicity complications.

Pattern of Acute Corrosives Poisoning at Poisoning Control Unit: A One Year Retrospective Clinical Study.

“…The present study showed that males are more likely (61.2%) to suffer from corrosive injuries than females (Table 1); and this may be because the boys have more mobile behavior than the girls making them more vulnerable to poisoning (Seif et al, 2016). The existing result was in line with the study done by Ghonem and El Sharaby (2018) in their work on complications of acute corrosive toxicity who detected that 52.3% of corrosive poisoning were males compared to 47.7% of females. Also Halawa et al (2013) in their study on annual report of the Poison Control Centre, Ain Shams University Hospitals, Cairo , Egypt; reported that 55% male children were subjected to poisoning.…”

“…As regards the residence, the present work revealed that most of cases (58%) came from rural areas (Table 1); this may be explained as BPCU serves the city of Benha and the surrounding villages most of which are considered rural. Ghonem and El Sharaby (2018) founded at their work at Mansoura Toxic center; that the majority of patients (65.9%) were from rural areas. In contrast to the current work, Manzar et al(2010) in Pakistan reported that children came from urban areas were more vulnerable (85%) compared to those who came from rural areas (15%).…”

“…The mean delay time between poisoning and admission to hospital in the present work was relatively short (0.9 h.) and ranged from 0.5-2 hours (Table 2); this may explain the high percentage of improved outcome. Ghonem and El Sharaby (2018) reported that the delay time in their work wasfrom 0.5-10 hours. In contrast to the results obtained by Abd El-Salam et al (2013) in their work on Poison Control Center -Ain Shams University , who reported the highest mean delay time in cases of corrosive cases was (10.62 hr.)…”

The Potential Role of Procalcitonin Compared to C-reactive protein and Neutrophil Lymphocyte Ratio in Prediction of Severity and Outcomes of Acute Corrosive Ingestion

“…Neutrophil lymphocyte ratio is considered a robust inflammatory parameter, owing to the possibility of implementing its parameter simply by using the already available subtype counts of white blood cells to evaluate inflammatory conditions (Fuss et al, 2018;Lattanzi et al, 2018). NLR combines two independent markers of inflammation; neutrophilia reflects inflammation, whereas lymphocytopenia reflects poor general health and physiologic stress (Kim et al, 2015;Ghonem & El Sharaby, 2018). Gürağaç & Demirer, (2016) clarified the beneficial role of NLR in prediction of inflammatory process even when leucocyte count is within the normal range.…”

Çocuk Acil Servise Zehirlenme İle Başvuran Hastaların Sosyodemografik ve Laboratuvar Verilerinin İncelenmesi

“…Özellikle enflamasyon, koroziv toksisite komplikasyonlarının gelişimi için bir predispozan faktör olarak kabul edilir. Toplam WBC, nötrofil sayısı ve NLO koroziv toksisitesi için prediktör belirteçler olarak değerlendirilmiştir 31 .Çalışmamızda temizlik malzemeleri ile zehirlenmede lökosit sayısı anlamlı düzeyde yüksek, kostik koroziv madde zehirlenmelerinde de anlamlı olduğu tespit edildi. Zehirlenme vakaların CRP takibi ile prognoz ve mortalite arasındaki ilişki ortaya konmuştur ve CRP takibi ile toksikasyona bağlı enflamasyonun ilişkisi bilinmektedir 32 .…”