Leucocyte ascorbic acid levels after acute myocardial infarction.

Hume, Robert; Weyers, Elspeth; Rowan, T; Reid, D S; Hillis, W S

doi:10.1136/hrt.34.3.238

Cited by 53 publications

(27 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…following acute myocardiar infarction although in that instance the L.A.A. took approximately 14 days to return to normal (Hume et al, 1972). It would appear, therefore, that both major and minor 'stresses' can have a profound effect on L.A.A.…”

Section: Discussionmentioning

confidence: 99%

Changes in Leucocyte Ascorbic Acid during the Common Cold

1973

View full text Add to dashboard Cite

Summary. Leucocyte ascorbic acid was measured in 7 subjects during the common cold. There was a significant fall in L. A.A. to Pauling (1970), there has been much discussion in the public press and elsewhere both in America and in this country on the prophylactic and therapeutic value of ascorbic acid in infections by the common cold virus.During the winter of 1971, we were able to observe the changes occurring in the leucocyte ascorbic acid levels (L.A.A.) in 7 individual members of the staff of one medical unit in a general hospital, during an outbreak of the common cold. Ascorbic acid saturation tests were also carried out to determine whether there was an optimum dose of ascorbic acid which would saturate both the white blood cells and the serum. The effect of 'optimum' doses of ascorbic acid during further episodes of the common cold was studied in 3 individuals. In view of the difficulty in carrying out detailed studies on individuals who are harbouring the common cold virus and who are taking supplements of ascorbic acid, we felt that these observations also were worth reporting. MATERIAL AND METHODS SubjectsSeven members (2 males and 5 females) of the medical and nursing staff were studied while suffering from the common cold. By chance, 4 individuals had measurements of their L.A.A. performed during the week prior to the onset of symptoms. Six individuals had measurements performed on the first day of symptoms; 5 on the second day of symptoms; 7 on the third day of symptoms; 5 on the fourth day of symptoms; 3 on the fifth day of symptoms and 7 on the tenth day of symptoms. Symptoms had usually subsided by the fifth day.

show abstract

Section: Discussionmentioning

confidence: 99%

Changes in Leucocyte Ascorbic Acid during the Common Cold

1973

View full text Add to dashboard Cite

show abstract

“…Even then extrapolation of whole-body reserves from white cell measurements in these populations may be difficult as changes occur rapidly in leucocyte vitamin C in acute disease (Hume et al 1972;Hume & Weyers, 1973) and may not necessarily reflect changes in whole-body reserves. However, the study of such changes is of interest as it leads to a better understanding of fluctuations in vitamin C metabolism during disease.…”

Section: Assay Of Vitamin Cmentioning

confidence: 99%

The level of vitamin C reserves required in man: towards a solution to the controversy

Schorah

1981

Proc. Nutr. Soc.

View full text Add to dashboard Cite

“…Vitamin C is rapidly depleted in acute infections (Thomas & Holt, 1978) and in the repair of acute tissue damage (Hume et al, 1972). Many of the chronic diseases associated with low blood values for vitamin C have an immunological component (Thomas & Holt, 1978;Mullen & Wilson, 1976;Olusi et al, 1979).…”

mentioning

confidence: 99%

Severe hypovitaminosis C in lung-cancer patients: the utilization of vitamin C in surgical repair and lymphocyte-related host resistance

Anthony¹,

Schorah²

1982

Br J Cancer

106

View full text Add to dashboard Cite

Summary.-Plasma and buffy-coat vitamin C were estimated in 158 samples from 139 lung-cancer patients, at all stages of the disease. Most samples showed hypovitaminosis C in both estimations: 64% had plasma, and 25% buffy-coat values below the thresholds for incipient clinical scurvy (0.3 mg% and 10 jg/108 cells respectively).Levels were diet-dependent and could be increased by oral supplements. Levels were low both in tumour-bearing patients and in those clinically free of disease after resection. The latter had particularly low values during the first 6 months, indicating the utilization of vitamin C in surgical repair.The vitamin C content of 13 primary lung tumours was assayed: tumours had a higher vitamin C content (mean 1116 +551 ,ug/g tissue) than normal lung (58.5 + 20-4 ,ug/g).Mononuclear cells from normal individuals show a higher vitamin C content than polymorphs, but in lung -cancer patients the expected correlation of buffy-coat vitamin C with the proportion of lymphocytes in peripheral blood was obscured by an inverse correlation in patients with relative lymphocytosis (.25% lymphocytes), confirmed by an inverse correlation of the proportion of lymphocytes in peripheral blood with mononuclear-cell vitamin C in 14 patients in whom this was measured. These correlations were unaffected by controlling for plasma values, and indicate the utilization of vitamin C in lymphocyte-related anti-tumour mechanisms.Vitamin C is necessary for phagocytosis and for the expression of cell-mediated immunity. In view of the increasing circumstantial evidence that immune mechanisms exert some measure of control on tumour extension and metastasis in man, the effect of supplementation with vitamin C in lung-cancer patients on survival should be tested in a clinical trial.

show abstract

Leucocyte ascorbic acid levels after acute myocardial infarction.

Cited by 53 publications

References 13 publications

Changes in Leucocyte Ascorbic Acid during the Common Cold

Changes in Leucocyte Ascorbic Acid during the Common Cold

The level of vitamin C reserves required in man: towards a solution to the controversy

Severe hypovitaminosis C in lung-cancer patients: the utilization of vitamin C in surgical repair and lymphocyte-related host resistance

Contact Info

Product

Resources

About