Leucocyte Adherence Inhibition for Detecting Specific Tumour Immunity in Early Pancreatic Cancer

Tataryn, Donna N.; MacFarlane, John K.; Thomson, David M.

doi:10.1016/s0140-6736(78)90742-0

Cited by 40 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Leucocyte reactivity in experimental animals with large tumour masses has been shown to be diminished (Leveson et al, 1977) and Grosser& Thomson (1975) demonstrated a similar phenomenion in patients with advanced breast cancer. Recently, studies of LAI in pancreatic (Tataryn et al, 1978), breast (Lopez et al, 1977) and colorectal carcinomas (Shani et al, 1978) may obviate these shortcomings.…”

Section: Subjects Studied and Methodsmentioning

confidence: 99%

“…More recently the leucocyte adherence inhibition (LAI) test has been developed as a simple and rapid technique for detecting cell-mediated immune response to soluble tumour-associated antigens (Halliday & Miller, 1972;Halliday et al, 1974;Grosser & Thomson, 1975). This test has been used in assessing reactivity to a wide variety of tumours (Tataryn et al, 1978;Maluish & Halliday, 1974) including hepatocellular carcinoma (HCC) . In the latter study, positive LAI tests were found in a few patients with HCC.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of leucocyte adherence inhibition in hepatocellular carcinoma

Dusheiko¹,

Kew²,

Rabson³

1979

Br J Cancer

View full text Add to dashboard Cite

Summary.-The value of the leucocyte adherence inhibition (LAI) test in the diagnosis of hepatocellular carcinoma (HCC) was investigated in 36 patients with this tumour. The sensitivity and specificity of the tube LAI test was assessed in 21 patients with HCC, 15 apparently healthy individuals, 9 patients with various forms of benign liver disease and 5 patients with non-hepatic neoplasms. In only 42% of the HCC patients tested was leucocyte adherence to glass reduced to a greater extent than in the healthy controls and in the patients with non-hepatic neoplasms, and the differences were not statistically significant. Moreover, positive results were obtained in 6/9 patients with benign hepatic disease. A further 15 patients were tested against extracts of HCC tissue using the haemacytometer LAI method. Of these, 53o% gave positive results. In all, only 17/36 patients (47°,) gave positive LAI responses. The test is thus of limited value in the diagnosis of HCC. The high false-negative result rate may be due either to abrogation of the immune response in HCC patients with large tumour burdens or to antigenic heterogeneity in HCC.

show abstract

Section: Subjects Studied and Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Evaluation of leucocyte adherence inhibition in hepatocellular carcinoma

Dusheiko¹,

Kew²,

Rabson³

1979

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…Numerous experimental LAI assays were made for quantitative assessment of CMI of leukocytes of tumor-specific cell-mediated immunity (Burger et al, 1979;Gipson and Martin, 1978;Hellstroem et al, 1976;Marti and Thomson 1976;Noonan et al, 1977;Tataryn et al, 1978).…”

Section: Leukocyte Adherence Inhibition Assaymentioning

confidence: 99%

Changes of Leukocyte Adherence Ability Under the Influence of Magnetic Field in the Course of a Treatment of Patients with Laryngeal and Pharyngeal Carcinoma

Čoček

Hahn

Ambruš

et al. 2008

Electromagnetic Biology and Medicine

View full text Add to dashboard Cite

The authors were monitoring adherence ability of T lymphocytes in vitro in patients with laryngeal and pharyngeal carcinoma at the presence of tumor-specific and viral LDH antigen. The results were assessed and expressed in percent of non adherent T lymphocytes (NAL). First, NAL in patients before initiating the treatment was compared with NAL control group (voluntary blood donors). The ability of the adherence in T lymphocytes in the control group is statistically significantly higher. Further on, NAL in the course of a successful oncological treatment was monitored at the interval of 6 months following the treatment, and further on at yearly intervals. NAL level drops statistically significantly within 6 months and then hold on at levels with no statistical difference unlike the control group, however, the ability of T lymphocyte in patients to adhere remains statistically significantly lower. Statistically significantly higher levels of NAL are at the presence of LDH viral antigen. Further on, the authors were following the influence of magnetic sinusoidal field of power frequency (50 Hz) of a low induction (0.5, 0.1, and 0.05 mT) on NAL. NAL values under the influence of an experimental magnetic field before initiating the treatment as well as in the course of a successful oncological treatment are statistically significantly lower. It means that magnetic filed increases the adherence ability of T lymphocytes in patients with laryngeal and pharyngeal cancer in vitro.

show abstract

“…An in vitro quantitative technique widely used to monitor cell-mediated immunity is the leukocyte adherence inhibition (LAI) assay based on observation of adherence of leukocytes to solid state substrates in the presence or absence of antigens (Gipson and Martin, 1978;Grosser and Thomson, 1975;Halliday and Miller, 1972;Hellstro¨em et al, 1976;Hola´nˇet al, 1974;Koppi et al, 1979;Marti and Thomson, 1976;Noonan et al, 1977;Shani et al, 1978;Tataryn et al, 1978;Thomson et al, 1979) (an overview is in Jandova´et al, 2001). The antigen is bound to its corresponding receptor in the plasma membrane and consequently changes the cell adherence properties.…”

Section: Introductionmentioning

confidence: 99%

Effects of Sinusoidal 0.5 mT Magnetic Field on Leukocyte Adherence Inhibition

Jandová

Pokorný

Čoček

et al. 2004

Electromagnetic Biology and Medicine

View full text Add to dashboard Cite

Exposure of T lymphocytes to an external 50 Hz and 0.5 mT magnetic field was investigated in vitro using leukocyte adherence inhibition (LAI) assay which is a measure of cell-mediated immunity. Adherence of T lymphocytes taken from healthy humans and from cancer patients before and after medical treatment is enhanced after 1 h exposure to the magnetic field. The experimental findings for the magnetic field 0.5 mT are compared with published data for 1 and 10 mT. The results are consistent with suggestions of magnetic field effects on immune function in humans.

show abstract

Leucocyte Adherence Inhibition for Detecting Specific Tumour Immunity in Early Pancreatic Cancer

Cited by 40 publications

References 13 publications

Evaluation of leucocyte adherence inhibition in hepatocellular carcinoma

Evaluation of leucocyte adherence inhibition in hepatocellular carcinoma

Changes of Leukocyte Adherence Ability Under the Influence of Magnetic Field in the Course of a Treatment of Patients with Laryngeal and Pharyngeal Carcinoma

Effects of Sinusoidal 0.5 mT Magnetic Field on Leukocyte Adherence Inhibition

Contact Info

Product

Resources

About