Evaluation of leucocyte adherence inhibition in hepatocellular carcinoma

Abstract

Summary.-The value of the leucocyte adherence inhibition (LAI) test in the diagnosis of hepatocellular carcinoma (HCC) was investigated in 36 patients with this tumour. The sensitivity and specificity of the tube LAI test was assessed in 21 patients with HCC, 15 apparently healthy individuals, 9 patients with various forms of benign liver disease and 5 patients with non-hepatic neoplasms. In only 42% of the HCC patients tested was leucocyte adherence to glass reduced to a greater extent than in the healthy controls and in the patients with non-hepatic neoplasms, and the differences were not statistically significant. Moreover, positive results were obtained in 6/9 patients with benign hepatic disease. A further 15 patients were tested against extracts of HCC tissue using the haemacytometer LAI method. Of these, 53o% gave positive results. In all, only 17/36 patients (47°,) gave positive LAI responses. The test is thus of limited value in the diagnosis of HCC. The high false-negative result rate may be due either to abrogation of the immune response in HCC patients with large tumour burdens or to antigenic heterogeneity in HCC.

The Humoral Leukocyte Adherence Inhibition in the Discrimination among Histologic Types of Lung Cancer

“…[18], using the hcmocytomcter meth od, made similar findings. As to the negative results in several patients tested against allogeneic extracts, it should be borne in mind that not all tumor extracts are "reactive' and induce inhibition of leukocyte ad herence [6,7,23].…”

Evaluation of leukocyte adherence inhibition (LAI) test in primary and secondary hepatic malignancies

“…Thus, LA1 test was found to be useful in the diagnosis of hepatic malignancies. [2,6,71. In the present study the diagnostic value of LA1 was assessed in primary and secondary carcinomas of the liver.…”