Inhibition of leukocyte adherence by 3 M potassium chloride extracts of human malignant melanoma

Ichiki, Albert T.; Quirin, Yvonne P.; Krauss, Stephen; Sonoda, Takuo

doi:10.1016/0304-3835(81)90077-x

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…We have demonstrated that for 70 colorectal cancer pa tients, the overall sensitivity and specificity of the assay were 0.54 and 0.91. respectively. Somewhat sim ilar figures in respect to the assay sensitivity were reported by Armitstead and Gowland [1] using the hcmocytometer method, and by Ayeni et al [2] and Ichiki et al [12] using the tube method. By contrast.…”

Section: Discussionmentioning

confidence: 87%

Leukocyte Adherence Inhibition Assay in the Diagnosis and Follow-Up of Colorectal Cancer Patients

Weisman¹,

Shani²,

Fink³

et al. 1986

Oncology

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Antitumor immune response to colorectal cancer extract was tested by the tube leukocyte adherence inhibition (LAI) assay. Of 70 colorectal cancer patients, 38 (54%) were LAI-positive. In contrast, 15 of 159 (9%) healthy individuals and 2 of 28 (7%) patients with nonmalignant diseases were positive. The LAI activity disappeared a few months after surgery and remained negative in patients with no evidence of disease as well as in patients with disseminated progressed disease. A change of LAI from negative to positive during the follow up period correlated in some cases with the recurrence of the disease, but was observed also in cases with no clinical evidence of disease.

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Section: Discussionmentioning

confidence: 87%

Leukocyte Adherence Inhibition Assay in the Diagnosis and Follow-Up of Colorectal Cancer Patients

Weisman¹,

Shani²,

Fink³

et al. 1986

Oncology

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Opioid-free versus opioid-based anesthesia in pancreatic surgery

et al. 2022

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Background Opioid-free anesthesia (OFA) is associated with significantly reduced cumulative postoperative morphine consumption in comparison with opioid-based anesthesia (OBA). Whether OFA is feasible and may improve outcomes in pancreatic surgery remains unclear. Methods Perioperative data from 77 consecutive patients who underwent pancreatic resection were included and retrospectively reviewed. Patients received either an OBA with intraoperative remifentanil (n = 42) or an OFA (n = 35). OFA included a combination of continuous infusions of dexmedetomidine, lidocaine, and esketamine. In OBA, patients also received a single bolus of intrathecal morphine. All patients received intraoperative propofol, sevoflurane, dexamethasone, diclofenac, neuromuscular blockade. Postoperative pain management was achieved by continuous wound infiltration and patient-controlled morphine. The primary outcome was postoperative pain (Numerical Rating Scale, NRS). Opioid consumption within 48 h after extubation, length of stay, adverse events within 90 days, and 30-day mortality were included as secondary outcomes. Episodes of bradycardia and hypotension requiring rescue medication were considered as safety outcomes. Results Compared to OBA, NRS (3 [2–4] vs 0 [0–2], P < 0.001) and opioid consumption (36 [24–52] vs 10 [2–24], P = 0.005) were both less in the OFA group. Length of stay was shorter by 4 days with OFA (14 [7–46] vs 10 [6–16], P < 0.001). OFA (P = 0.03), with postoperative pancreatic fistula (P = 0.0002) and delayed gastric emptying (P < 0.0001) were identified as only independent factors for length of stay. The comprehensive complication index (CCI) was the lowest with OFA (24.9 ± 25.5 vs 14.1 ± 23.4, P = 0.03). There were no differences in demographics, operative time, blood loss, bradycardia, vasopressors administration or time to extubation among groups. Conclusions In this series, OFA during pancreatic resection is feasible and independently associated with a better outcome, in particular pain outcomes. The lower rate of postoperative complications may justify future randomized trials to test the hypothesis that OFA may improve outcomes and shorten length of stay.

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Inhibition of leukocyte adherence by 3 M potassium chloride extracts of human malignant melanoma

Cited by 2 publications

References 22 publications

Leukocyte Adherence Inhibition Assay in the Diagnosis and Follow-Up of Colorectal Cancer Patients

Leukocyte Adherence Inhibition Assay in the Diagnosis and Follow-Up of Colorectal Cancer Patients

Opioid-free versus opioid-based anesthesia in pancreatic surgery

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