Letter: role of tenofovir to prevent mother‐to‐child transmission of hepatitis B virus

Cy, Zhang; Bk, Ahir; Gb, Wu; Zhong, Jian‐Hong; Lq, Li

doi:10.1111/apt.14189

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…The above evidence fully demonstrated that 15 mg kg −1 WDNs inhibited PH‐induced RV hypertrophy and improved RV dysfunction. In addition, natural antioxidants such as GSH, [ 41 ] vitamin C, [ 42 ] and clinical drugs for PH treatment fasudil [ 43 ] were conducted for comparison. As shown in Figures S9 and S10, Supporting Information, these control treatments had a negligible therapeutic effect at the samedose as WNDs.…”

Section: Resultsmentioning

confidence: 99%

Natural Targeting Potent ROS‐Eliminating Tungsten‐Based Polyoxometalate Nanodots for Efficient Treatment of Pulmonary Hypertension

Liu

Wang

Chen

et al. 2023

Adv Healthcare Materials

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Pulmonary hypertension (PH) is a disease of pulmonary artery stenosis and blockage caused by abnormal pulmonary artery smooth muscle cells (PASMCs), with high morbidity and mortality. High levels of reactive oxygen species (ROS) in pulmonary arteries play a crucial role in inducing phenotypic switch and abnormal proliferation of PASMCs. However, antioxidants are rarely approved for the treatment of PH because of a lack of targeting and low bioavailability. In this study, the presence of an enhanced permeability and retention effect (EPR)‐like effect in the pulmonary arteries of PH is revealed by tissue transmission electron microscopy (TEM). Subsequently, for the first time, tungsten‐based polyoxometalate nanodots (WNDs) are developed with potent elimination of multiple ROS for efficient treatment of PH thanks to the high proportion of reduced W5+. WNDs are effectively enriched in the pulmonary artery by intravenous injection because of the EPR‐like effect of PH, and significantly prevent the abnormal proliferation of PASMCs, greatly improve the remodeling of pulmonary arteries, and ultimately improve right heart function. In conclusion, this work provides a novel and effective solution to the dilemma of targeting ROS for the treatment of PH.

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Section: Resultsmentioning

confidence: 99%

Natural Targeting Potent ROS‐Eliminating Tungsten‐Based Polyoxometalate Nanodots for Efficient Treatment of Pulmonary Hypertension

Liu

Wang

Chen

et al. 2023

Adv Healthcare Materials

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“…Therefore, antiviral therapy to prevent vertical transmission of HBV is important to mothers with serum HBeAg-positive status and/or high HBV DNA. 1 In a recent issue of Alimentary Pharmacology & Therapeutics, Wang et al 2 performed an interesting prospective study with single arm to investigate the efficacy and safety of tenofovir disoproxil fumarate to prevent mother-to-child transmission of HBV. In their study, alanine aminotransferase flares were observed in 8.4% of mothers; no infants had birth defects and no serious adverse effects were observed in either mothers or infants.…”

mentioning

confidence: 99%

Letter: tenofovir disoproxil fumarate is safe for prevention of mother‐to‐child transmission of hepatitis B virus

Fan

Zhao

2019

Aliment Pharmacol Ther

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