Letter: liver transplantation for acute HEV infection in cirrhotic patients in France

Abstract

International audienceno abstrac

Systematic review with meta‐analysis: the association between hepatitis E seroprevalence and haemodialysis

“…Hepatitis E virus infection can be a serious disease, with manifestations ranging from acute liver failure, to acute‐on‐chronic liver failure or chronic hepatitis in immunosuppressed patients . Moreover, it may not be readily recognised at times, as it may masquerade as drug‐induced liver injury or as myriad of extrahepatic manifestations, such as neurological manifestations, acute pancreatitis, cryoglobulinemic disease, acute liver failure and chronic renal disease .…”

“…Moreover, it may not be readily recognised at times, as it may masquerade as drug‐induced liver injury or as myriad of extrahepatic manifestations, such as neurological manifestations, acute pancreatitis, cryoglobulinemic disease, acute liver failure and chronic renal disease . These manifestations are not limited to developing countries, but also being reported more frequently in developed nations . The prevalence of anti‐HEV surpasses that of anti‐hepatitis A virus in some United States regions, which gives importance in recognising this potentially blood‐borne pathogen in a growing end‐stage renal disease population.…”

“…The hepatitis E virus (HEV) is most commonly transmitted faecal‐orally, although parenteral transmission also occurs. Although HEV infection was previously thought to be rare, increasing reports from both endemic and nonendemic countries are being described, and though initially thought to be a self‐limiting disease, cases of chronic infection in immunosuppressed patients are increasing, leading to cirrhosis requiring liver transplantation, and at times, fulminant liver failure or severe extrahepatic manifestations . Transfusion of blood products and maintenance haemodialysis (HD) have been implicated as potential sources of transmission .…”

Investigations by the Institut Hospitalo-Universitaire Méditerranée Infection of food and food-borne infections in the Mediterranean Basin and in sub-Saharan Africa

“…Although HEV is mostly documented as involved in likely waterborne outbreaks in sub-Saharan Africa, we also detected HEV in farm pigs in this geographical area [35] . Concurrent with being revealed as having an extensive porcine reservoir, HEV was reported to cause acute liver failure and death [36] , [37] . Furthermore, HEV was shown to be capable of determining chronic hepatitis in solid organ transplant recipients [38] , [39] .…”