Letter: Fluorescence Guidance and Intraoperative Adjuvants to Maximize Extent of Resection

In Reply: Fluorescence Guidance and Intraoperative Adjuvants to Maximize Extent of Resection

“…1 Electrophysiologic adjuncts are equally, and in some cases, more important for achieving optimal outcomes in brain tumor surgery but are reviewed elsewhere in this series. 2,3 Although direct cortical stimulation mapping, either awake or under anesthesia, is a much more widely embraced and available adjunct for brain mapping in the context of tumor surgery than navigated transcranial magnetic stimulation, both may have value as expressed by Rahman et al 4 In previous studies, navigated transcranial magnetic stimulation has been shown to significantly reduce postoperative motor deficit and increase extent of resection and rate of gross total resection if used for preoperative planning. 5,6 In addition, there is a growing understanding fueled by our knowledge of connectomics that tools limited to mapping motor and language function through direct cortical and subcortical may underestimate the relevant complexity and nuances of the human brain.…”